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Lactobacillus Rhamnosus Helps to Reduce the Duration of Bleeding in Breastfed Infants With Allergic Proctocolitis Publisher Pubmed



Malekiantaghi A1 ; Ghanaati F1 ; Shabanimirzaee H2 ; Shariat M3 ; Mojtahedi SY4 ; Eftekhari K5
Authors
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Authors Affiliations
  1. 1. Department of Pediatric, Bahrami Children’s Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pediatric Endocrinology, Bahrami Children’s Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Fetal & Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pediatric Nephrology, Bahrami Children’s Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pediatric, Pediatric Gastroenterology and Hepatology Research Center, Bahrami Children’s Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Breastfeeding Medicine Published:2025


Abstract

Background: Cow’s milk protein allergy (CMPA) is the most common food allergy in infants. The current standard of care (SOC) involves eliminating the allergen from both the infant’s and mother’s diet for 2-4 weeks. The purpose of this study is to assess the effectiveness of Lactobacillus rhamnosus (Ramnoflor) in reducing the duration of bleeding in these infants. Methods: This randomized clinical trial was conducted at Bahrami Children’s Hospital on breastfed infants who were diagnosed with CMPA and had a positive occult blood (OB) test. Patients were randomly assigned to either the control or case groups. All patients received SOC therapy, with the case group receiving Ramnoflor and the control group receiving a placebo. Data were recorded on the checklist, and the children were followed and visited three times during the study, with an OB assessment at each visit. Results: The study enrolled 48 infants. Among the infants in the case group, the OB test was positive in four cases (8.3%) on the fifth day. However, there were no positive cases on the 14th and 30th days. The prevalence of this test was significantly lower in patients who received probiotics compared to the control group on the fifth day (p < 0.001). There were no positive OB tests on the 14th and 30th days in any of the groups, and no significant difference was observed between the groups. Conclusion: The addition of L. rhamnosus to SOC therapy led to a decrease in the duration of rectal bleeding in infants with CMPA compared to the control group. Copyright 2025, Mary Ann Liebert, Inc., publishers.