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Hynic a Bifunctional Prosthetic Group for the Labelling of Peptides With 99Mtc and 18Fdg Publisher



Khoshbakht S1 ; Kobarfard F2 ; Beiki D3 ; Sabzevari O4 ; Amini M5 ; Mehrnejad F6 ; Tabib K7 ; Shahhosseini S8, 9
Authors
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Authors Affiliations
  1. 1. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmaceutical Chemistry, School of Pharmacy, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Vali-e Asr Ave., Niayesh Junction, P.O.Box 14155-6153, Tehran, Iran
  3. 3. Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Toxicology & Pharmacology, Faculty of Pharmacy, and Toxicology and Poisoning Research Centre, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medicinal Chemistry, and Drug Design and Development Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran, P.O.Box: 14395-1561, Tehran, Iran
  7. 7. Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. PET/CT Unit, Ferdous Nuclear Medicine Center, Dr Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Vali-e Asr Ave., Niayesh Junction, P.O.Box 14155-6153, Tehran, Iran

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2016


Abstract

With regard to high reactivity and chemoselectivity of HYNIC towards carbonyl of acyclic form of 18FDG and its stable complexes with 99mTc, in this study, LIKKPF as the model peptide was conjugated with HYNIC and labelled with 99mTc (RCP >90 %) and 18FDG for the first time. The RCP of >70 % was achieved for labelling with 18FDG, in the presence of glucose (50–250 μg/mL). Our results showed the high potential of HYNIC conjugated peptides for labelling with 99mTc and 18FDG as 18F-fluorinated prosthetic group, to be clinically accepted for the radiolabelling of peptides. © 2015, Akademiai Kiado, Budapest, Hungary.
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