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Genetic Characterization of G Protein in Respiratory Syncytial Virus On-1 Genotype in Tehran Publisher



Malekshahi SS1 ; Samieipour Y2 ; Rahbarimanesh AA3 ; Izadi A3 ; Ghavami N2 ; Razaghipour S4 ; Naseri M2 ; Mokhtariazad T2 ; Salimi V2
Authors
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Authors Affiliations
  1. 1. Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  2. 2. Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Future Virology Published:2020


Abstract

Aim: We investigated the genetic characterization of the respiratory syncytial virus (RSV) ON-1 genotypes and their different lineages based on the G gene among children <2 years of age presenting with acute respiratory tract infections in Tehran, Iran. Materials methods: A phylogenetic tree from the Iranian samples and ON-1 strains of various parts of the world were constructed. The amino acid composition of the RSV G protein of the ON-1 genotype was mapped. Results: Human RSV ON-1 genotypes from the Iranian samples clustered in three lineages. The most common amino acid substitutions were as follows: X218Q, I240S, L289P, Y304H and L310P. Conclusion: Continuing molecular epidemiological surveys in other regions of Iran will provide deeper insight into the nature of this replacement of the dominant RSV genotype from GA2 to ON-1 in Iran. © 2020 Future Medicine Ltd.. All rights reserved.
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