Interplay Between Cellular Metabolism and Dna Viruses Publisher Pubmed



Zandi M¹ ; Shokri S^{2, 3} ; Mahmoudvand S^{2, 3} ; Hosseinzadeh Adli A^{1, 4} ; Mohammadi R⁵ ; Haddadi A⁵
Source: Journal of Medical Virology Published:2022

Abstract

Viruses as intracellular pathogens take over the host metabolism and reprogram to facilitate optimal virus production. DNA viruses can cause alterations in several metabolic pathways, including aerobic glycolysis also known as the Warburg effect, pentose phosphate pathway activation, and amino acid catabolism such as glutaminolysis, nucleotide biosynthesis, lipid metabolism, and amino acid biosynthesis. The available energy for productive infection can be increased in infected cells via modification of different carbon source utilization. This review discusses the metabolic alterations of the DNA viruses that will be the basis for future novel therapeutic approaches. © 2022 Wiley Periodicals LLC.