Disturbance in the Reconstitution of Distinct T-Cell Subsets and the Incidence of Gvhd Following Allo-Hsct in Pediatric Patients With Non-Malignant Hematological Disorders

Disturbance in the Reconstitution of Distinct T-Cell Subsets and the Incidence of Gvhd Following Allo-Hsct in Pediatric Patients With Non-Malignant Hematological Disorders Publisher Pubmed

Bayegi SN^{1, 2} ; Hamidieh AA² ; Behfar M² ; Bozorgmehr M³ ; Saghazadeh A^{4, 5} ; Tajik N^{1, 6} ; Delbandi AA^{1, 6} ; Zavareh FT^{4, 7} ; Delavari S^{4, 9} ; Shekarabi M⁶ ; Rezaei N^{4, 8, 10}

Show Affiliations

1. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2. Pediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
4. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
5. Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
6. Immunology Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
7. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
8. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
9. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran
10. Network of Immunity in Infection, Malignancy, and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Immunology Letters Published:2023

Abstract

Background: The reconstitution of different T-cell subsets following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is critical for efficient pathogen protection and the prevention of graft-versus-host disease (GvHD). In particular, studies have highlighted the importance of balanced ratios of regulatory T-cells (Tregs) and distinct functionally T-cells in preventing acute and chronic GvHD. Methods: We evaluated the regeneration of CD4 and CD8 T-cell subpopulations in nine pediatric patients with non-malignant disorders following allo-HSCT from a fully HLA-identical donor. Results: CD4 and CD8 T-cells were higher 12 months after the transplant but still lower than in healthy controls and pre-transplant. However, we found after allo-HSCT, central memory and effector memory cell subsets were the predominant phenotypes in the CD4 and CD8 T-cell populations, respectively. In patients who had developed acute GvHD, there was an increase in the frequency of TEMRA (effector memory T cells that re-express CD45RA) cells within the CD4 T-cell population. Meanwhile, in patients with chronic GvHD, we observed a decrease in Th1 cells in CD4 T-cells and effector memory cells within the CD8 T-cell population. In addition, we found decreased TEMRA cell subsets in CD4 and CD8 T-cell populations in chronic GvHD. Conclusion: Our findings suggest a possible relationship between the influence of acute GvHD and its prevention on delayed CD4 T-cell reconstitution and, reciprocally, unbalanced regeneration of CD4 and CD8 T-cell subsets in the development of chronic GvHD. © 2023

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4. Assessment of a Poly-Epitope Candidate Vaccine Against Hepatitis B, C, and Poliovirus in Interaction With Monocyte-Derived Dendritic Cells: An Ex-Vivo Study, Human Immunology (2020)

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Nima Rezaei (4)

Maryam Behfar (3)

Style	Citing Format
MLA	Bayegi SN, et al.. "Disturbance in the Reconstitution of Distinct T-Cell Subsets and the Incidence of Gvhd Following Allo-Hsct in Pediatric Patients With Non-Malignant Hematological Disorders." Immunology Letters, vol. 261, no. , 2023, pp. 25-36.
APA	Bayegi SN, Hamidieh AA, Behfar M, Bozorgmehr M, Saghazadeh A, Tajik N, Delbandi AA, Zavareh FT, Delavari S, Shekarabi M, Rezaei N (2023). Disturbance in the Reconstitution of Distinct T-Cell Subsets and the Incidence of Gvhd Following Allo-Hsct in Pediatric Patients With Non-Malignant Hematological Disorders. Immunology Letters, 261(), 25-36.
Chicago	Bayegi SN, Hamidieh AA, Behfar M, Bozorgmehr M, Saghazadeh A, Tajik N, Delbandi AA, et al.. "Disturbance in the Reconstitution of Distinct T-Cell Subsets and the Incidence of Gvhd Following Allo-Hsct in Pediatric Patients With Non-Malignant Hematological Disorders." Immunology Letters 261, no. (2023): 25-36.
Harvard	Bayegi SN et al. (2023) 'Disturbance in the Reconstitution of Distinct T-Cell Subsets and the Incidence of Gvhd Following Allo-Hsct in Pediatric Patients With Non-Malignant Hematological Disorders', Immunology Letters, 261(), pp. 25-36.
Vancouver	Bayegi SN, Hamidieh AA, Behfar M, Bozorgmehr M, Saghazadeh A, Tajik N, et al.. Disturbance in the Reconstitution of Distinct T-Cell Subsets and the Incidence of Gvhd Following Allo-Hsct in Pediatric Patients With Non-Malignant Hematological Disorders. Immunology Letters. 2023;261():25-36.
BibTex	@article{ author = {Bayegi SN and Hamidieh AA and Behfar M and Bozorgmehr M and Saghazadeh A and Tajik N and Delbandi AA and Zavareh FT and Delavari S and Shekarabi M and Rezaei N}, title = {Disturbance in the Reconstitution of Distinct T-Cell Subsets and the Incidence of Gvhd Following Allo-Hsct in Pediatric Patients With Non-Malignant Hematological Disorders}, journal = {Immunology Letters}, volume = {261}, number = {}, pages = {25-36}, year = {2023} }
RIS	TY - JOUR AU - Bayegi SN AU - Hamidieh AA AU - Behfar M AU - Bozorgmehr M AU - Saghazadeh A AU - Tajik N AU - Delbandi AA AU - Zavareh FT AU - Delavari S AU - Shekarabi M AU - Rezaei N TI - Disturbance in the Reconstitution of Distinct T-Cell Subsets and the Incidence of Gvhd Following Allo-Hsct in Pediatric Patients With Non-Malignant Hematological Disorders JO - Immunology Letters VL - 261 IS - SP - 25 EP - 36 PY - 2023 ER -

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