Diagnostic Procedures for Improving of the Kit (Cd117) Expressed Allele Burden for the Liver Metastases From Uterus Mast Cell Tumors: Prognostic Value of the Metastatic Pattern and Tumor Biology

Diagnostic Procedures for Improving of the Kit (Cd117) Expressed Allele Burden for the Liver Metastases From Uterus Mast Cell Tumors: Prognostic Value of the Metastatic Pattern and Tumor Biology Publisher Pubmed

Hosseini E¹ ; Pedram B² ; Bahrami AM¹ ; Touni SR³ ; Malayeri HZ⁴ ; Mokarizadeh A⁵ ; Pourzaer M⁶ ; Pourzaer M⁶ ; Zehtabian S⁸ ; Mohajer S⁹ ; Ahmadi S¹⁰

Show Affiliations

1. Ilam University, Ilam, Iran
2. Department of Pathobiology, Susangerd Branch, Islamic Azad University, Susangerd, Iran
3. Department of Basic Science, Urmia University, Urmia, Iran
4. Department of Internal Medicine, Tehran University, Tehran, Iran
5. Department of Immunology, Kurdistan University of Medical Sciences, Sanandaj, Iran
6. Karaj Branch, Islamic Azad University, Alborz, Iran
7. Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
8. Department of Microbiology, Kermanshah University of Medical Sciences, Kermanshah, Iran
9. Chronic Respiratory Disease Research Center, National Research Institue of Tuberculosis and Lung Diseases, Massih Daneshvary Hospital, Shahid Beheshti University of Medicine, Tehran, Iran
10. Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Tumor Biology Published:2015

Abstract

The activating KIT marker plays a central role in the pathogenesis, diagnosis, and targeted treatment of systemic mastocytosis (SM). Recent studies have identified the KIT (CD117) as a marker that distinguishes nonneoplastic from neoplastic mast cells in human systemic mastocytosis. In this study, we conclude that immunohistopathology assays for KIT staining pattern are useful complimentary tools for diagnosis and evaluation of prognosis in uterus mast cell tumor (MCT) metastasis to the liver in 10 patients. Uterine and hepatic cytology revealed mast cell neoplasia, which was confirmed as visceral mast cell tumor on postmortem examination. Histological changes of densely packed, poorly differentiated neoplastic mast cells, sheets of neoplastic round to pleomorphic cells that formed nonencapsulated nodules, high mitotic figures, necrosis, and fibrosis were found. In addition, eosinophils were scattered among the mast cells at the periphery of the nodules. These findings indicate tumors of high-grade malignancy with infiltrative cells resembling the uterus MCT in the intraparenchymal and periparenchymal areas of the liver. Immunohistochemically, tumors were positive for KIT. The histopathologic features coupled with the KIT immunoreactivity led to diagnosis of high-grade uterus MCTs. Taken together, these findings suggest that CD117 may play a critical role in early uterus MCT development and may be a stimulatory factor in grade 3 MCT. Therefore, the result has supported our hypothesis that there was an increased opportunity to observe a higher CD117 staining pattern in high-grade MCTs. © 2014, International Society of Oncology and BioMarkers (ISOBM).

Style	Citing Format
MLA	Hosseini E, et al.. "Diagnostic Procedures for Improving of the Kit (Cd117) Expressed Allele Burden for the Liver Metastases From Uterus Mast Cell Tumors: Prognostic Value of the Metastatic Pattern and Tumor Biology." Tumor Biology, vol. 36, no. 2, 2015, pp. 929-937.
APA	Hosseini E, Pedram B, Bahrami AM, Touni SR, Malayeri HZ, Mokarizadeh A, Pourzaer M, Pourzaer M, Zehtabian S, Mohajer S, Ahmadi S (2015). Diagnostic Procedures for Improving of the Kit (Cd117) Expressed Allele Burden for the Liver Metastases From Uterus Mast Cell Tumors: Prognostic Value of the Metastatic Pattern and Tumor Biology. Tumor Biology, 36(2), 929-937.
Chicago	Hosseini E, Pedram B, Bahrami AM, Touni SR, Malayeri HZ, Mokarizadeh A, Pourzaer M, et al.. "Diagnostic Procedures for Improving of the Kit (Cd117) Expressed Allele Burden for the Liver Metastases From Uterus Mast Cell Tumors: Prognostic Value of the Metastatic Pattern and Tumor Biology." Tumor Biology 36, no. 2 (2015): 929-937.
Harvard	Hosseini E et al. (2015) 'Diagnostic Procedures for Improving of the Kit (Cd117) Expressed Allele Burden for the Liver Metastases From Uterus Mast Cell Tumors: Prognostic Value of the Metastatic Pattern and Tumor Biology', Tumor Biology, 36(2), pp. 929-937.
Vancouver	Hosseini E, Pedram B, Bahrami AM, Touni SR, Malayeri HZ, Mokarizadeh A, et al.. Diagnostic Procedures for Improving of the Kit (Cd117) Expressed Allele Burden for the Liver Metastases From Uterus Mast Cell Tumors: Prognostic Value of the Metastatic Pattern and Tumor Biology. Tumor Biology. 2015;36(2):929-937.
BibTex	@article{ author = {Hosseini E and Pedram B and Bahrami AM and Touni SR and Malayeri HZ and Mokarizadeh A and Pourzaer M and Pourzaer M and Zehtabian S and Mohajer S and Ahmadi S}, title = {Diagnostic Procedures for Improving of the Kit (Cd117) Expressed Allele Burden for the Liver Metastases From Uterus Mast Cell Tumors: Prognostic Value of the Metastatic Pattern and Tumor Biology}, journal = {Tumor Biology}, volume = {36}, number = {2}, pages = {929-937}, year = {2015} }
RIS	TY - JOUR AU - Hosseini E AU - Pedram B AU - Bahrami AM AU - Touni SR AU - Malayeri HZ AU - Mokarizadeh A AU - Pourzaer M AU - Pourzaer M AU - Zehtabian S AU - Mohajer S AU - Ahmadi S TI - Diagnostic Procedures for Improving of the Kit (Cd117) Expressed Allele Burden for the Liver Metastases From Uterus Mast Cell Tumors: Prognostic Value of the Metastatic Pattern and Tumor Biology JO - Tumor Biology VL - 36 IS - 2 SP - 929 EP - 937 PY - 2015 ER -

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