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Chemical Composition and Hepatoprotective Activity of Ethanolic Root Extract of Taraxacum Syriacum Boiss Against Acetaminophen Intoxication in Rats Publisher Pubmed



Nazari A1 ; Fanaei H2 ; Dehpour AR3 ; Hassanzadeh G4 ; Jafari M5 ; Salehi M6 ; Mohammadi M7
Authors
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Authors Affiliations
  1. 1. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  2. 2. Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
  3. 3. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biochemistry, Faculty of Medicine, Baqiyatallah (a.s) University of Medical Sciences, Tehran, Iran
  6. 6. Neuro Sciences Research Center, Baqiyatallah (a.s) University of Medical Sciences, Tehran, Iran
  7. 7. Department of Pharmaceutical Biotechnology, Faculty of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran

Source: Bratislava Medical Journal Published:2015


Abstract

Aim: In the present study, the role of ethanol extract of root of Taraxacum Syriacum Boiss (TSBE) against hepatotoxicity caused by acetaminophen (APAP) was studied. Methods: The chemical composition of roots of Taraxacum Syriacum Boiss was analyzed by SPME-GC/MS method. Hepatocellular injuries induced by acetaminophen (APAP) were assessed by liver histology, serum aminotransferase activities, antioxidant enzymes activity and lipid peroxidation in liver tissue. Results: TSBE was observed to exhibit hepatoprotective effect as demonstrated by significant decrease in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), and alkaline phosphatase (ALP) concentration, and by preventing liver histopathologic changes in rats with APAP hepatotoxicity. Administration of APAP, significantly increased, lactate dehydrogenase (LDH) and catalase (CAT) activity in liver tissue and pretreatment with TSBE returned these parameters to control group, moreover TSBE reduces APAP-induced hepatic Glutathione (GSH) depletion. Carvacrol (6.7 %) was the main polyphenolic compound of plant sample. Our results demonstrated hepatoprotective activity of TSBE in rat in vivo. Conclusions: We believe that the mechanism by which the extract was able to protect the liver from the oxidative stress generated by APAP is due to its antioxidant activity. These phenolic compounds of the extract act as antioxidants and free radical scavengers and reduce or inhibit the oxidative stress induced by APAP administration.
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