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The Potassium Channel Blocker, Dalfampridine Diminishes Ouabain-Induced Arrhythmia in Isolated Rat Atria Publisher Pubmed



Ghebleh Zadeh N1 ; Vaezi G1 ; Bakhtiarian A2, 3 ; Mousavi Z4 ; Shiravi A1 ; Nikoui V5
Authors
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Authors Affiliations
  1. 1. Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
  2. 2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pharmacology-Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
  5. 5. Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Archives of Physiology and Biochemistry Published:2019


Abstract

The aim of the present experiment was to investigate the possible antiarrhythmic effects of dalfampridine in ouabain-induced arrhythmia in rats. Twenty-four male rats including the control and dalfampridine-incubated (100 µM to 10 mM) ouabain-stimulated (40 µM) groups were used. After induction of anesthesia, the atria were isolated and the time of onset of arrhythmia and asystole were recorded. The contractile force of atria was also measured. Dalfampridine at concentration of 1 mM significantly postponed the onset of arrhythmia and asystole compared to control group (p ≤.05). Ouabain significantly increased the atrial beating rate in control group (p ≤.05), while pretreatment of isolated atria with dalfampridine reversed this effect. Incubation of isolated atria with ouabain did not alter the contractile force in both control- and dalfampridine-treated groups (p >.05). It is concluded that dalfampridine might possess antiarrhythmic properties in reducing the atrial arrhythmias. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
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