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Immunohistochemical Evidence for Involvement of Inflammatory Cytokines in Anti-Arrhythmic Effects of Rosuvastatin in Male Rats Publisher



Amini S1 ; Nikoui V2 ; Jazaeri F1 ; Khan MI3 ; Partoazar A4 ; Bakhtiarian A1, 4
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pharmacy, Kohat University of Science and Technology, Kohat, 26000, Pakistan
  4. 4. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Physiology and Pharmacology (Iran) Published:2020


Abstract

Introduction: Considering the cardioprotective and anti-inflammatory properties of statins, the aim of the present experiment was to investigate the possible involvement of inflammatory cytokines in anti-arrhythmic effects of rosuvastatin in both in vitro and in vivo experiments in rats. Methods: Three weeks after oral administration of either of rosuvastatin or vehicle, the atria were removed and after incubation with ouabain, time of onset of arrhythmia and asystole were recorded. We also used immunohistochemistry technique to identify the differentially expressed proteins interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α in atria. Results: Rosuvastatin significantly postponed the onset of arrhythmia compared to vehicle-treated group. Injection of ouabain increased the atrial expression of IL-1β, IL-6 and TNF-α proteins, while pretreatment of rats with rosuvastatin could significantly attenuate them. Conclusion: Our data suggest that rosuvastatin exerts anti-arrhythmic properties at least in part through modulation of inflammatory cytokines. 10.32598/ppj.24.2.60.
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