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The Possible Role of Interleukin-35 and Its Therapeutic Potential in Pemphigus Publisher Pubmed



Tavakolpour S1, 2 ; Kheiry F3 ; Mirsafaei HS2 ; Akhlaghdoust M4
Authors
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Authors Affiliations
  1. 1. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Islamic Azad University of Tehran Medical Science branch, Iran
  4. 4. Pars Advanced and Minimally Invasive Manners Research Center, Pars Hospital, Tehran, Iran

Source: International Immunopharmacology Published:2017


Abstract

Pemphigus is an autoimmune disease that causes blistering and is life-threatening if left untreated. Nowadays, finding a promising treatment for pemphigus remains a serious challenge. Various treatments are currently recommended to treat this disease, but they rarely lead to complete and durable remission. Regulatory cells appear to have a critical role in numerous autoimmune diseases, so it is possible that promotion of these cells may induce remission. This study presents a new approach to treating pemphigus that has not been discussed to date. This approach introduces interleukin (IL)-35 as a new treatment for pemphigus. This cytokine could induce two different types of regulatory cell, including IL-35-that produces induced regulatory T cells and IL-35+ regulatory B cells, which could suppress both effector T cells and effector B cells. It seems that IL-35 may act as an efficient therapeutic strategy for pemphigus. It probably limits progression of the disease and may even contribute to long-lasting remission. However, further study is required to evaluate the efficacy and safety of treating pemphigus with IL-35. © 2016 Elsevier B.V.
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