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Development and Characterization of a Bioglass/Chitosan Composite As an Injectable Bone Substitute Publisher Pubmed



Khoshakhlagh P1 ; Rabiee SM2 ; Kiaee G3 ; Heidari P4 ; Miri AK5 ; Moradi R6 ; Moztarzadeh F7 ; Ravarian R8
Authors
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Authors Affiliations
  1. 1. Department of Biomedical Engineering, Tulane University, New Orleans, LA, United States
  2. 2. Department of Mechanical Engineering, Babol (Noshirvani) University of Technology, Babol, Iran
  3. 3. Department of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States
  5. 5. Department of Mechanical Engineering, McGill University, Montreal, Quebec, Canada
  6. 6. Orthopedic Division, Milad Hospital, Tehran, Iran
  7. 7. Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
  8. 8. School of Chemical and Bimolecular Engineering, University of Sydney, Sydney, Australia

Source: Carbohydrate Polymers Published:2017


Abstract

SiO2-CaO-P2O5 based bioglass (BG) systems constitute a group of materials that have wide applications in bone implants. Chitosan (Cn) is a biocompatible and osteoconductive natural polymer that can promote wound healing. In this study, bioactivity of chitosan/bioglass (CnB) composites as minimally invasive bone regenerative materials was assessed both in vitro and in vivo. Injectability tests and scanning electron microscopy (SEM) results demonstrated the formation of uniform injectable paste-like composites using BG particles and Cn. Fourier transform infrared spectroscopy (FTIR) and SEM images confirmed hydroxyapatite deposition in vitro after incubation in simulated body fluid (SBF). Higher BG content in the composite correlated with increased human osteoblast proliferation. An in vivo study in a rat spinal fusion model confirmed that increasing the amount of BG improved osteoconductivity. Manual palpation, radiographic images and pathological assessments proved that the composites promote bone formation. Based on these data, the synthesized composites have a potential application in orthopedic and reconstructive surgeries as a minimally invasive bone substitute. © 2016 Elsevier Ltd
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