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Platinum-Based Chemotherapies-Induced Nephrotoxicity: Mechanisms, Potential Treatments, and Management Publisher Pubmed



Shahrahmani F1 ; Badamchizadeh S1 ; Kaihani F2 ; Alavimoghadam S1 ; Keshtkari S3 ; Rezaeitavirani M4 ; Arjmand R1 ; Larijani B5 ; Arjmand B1
Authors
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Authors Affiliations
  1. 1. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Iranian Cancer Control Center (MACSA), Tehran, Iran
  3. 3. Department of Internal Medicine, AJA University of Medical Sciences, Tehran, Iran
  4. 4. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: International Urology and Nephrology Published:2025


Abstract

Platinum-based chemotherapies are essential in the treatment of several malignancies. However, such medications can damage the kidneys, frequently leading to both acute and chronic kidney disease. Treatment becomes more difficult for such problems. Physicians may alter chemotherapy regimens and utilize kidney-protecting medications to lessen renal damage. New imaging techniques and biomarkers also aid in the early detection of renal issues. To effectively handle the mentioned situation, oncologists, nephrologists, and pharmacists must collaborate. However, additional study is still required to develop customized therapies, discover strategies to minimize kidney injury and produce new platinum medicines. Hereupon, the present review's authors are being sought to address the causes, prospective treatments, and management of nephrotoxicity caused by platinum-based chemotherapy. © The Author(s), under exclusive licence to Springer Nature B.V. 2024.
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