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Melatonin and Cisplatin Co-Treatment Against Cancer: A Mechanistic Review of Their Synergistic Effects and Melatonin's Protective Actions Publisher Pubmed



Rafiyan M1, 2 ; Davoodvandi A2, 3 ; Reiter RJ4 ; Mansournia MA5 ; Rasooli Manesh SM6 ; Arabshahi V7 ; Asemi Z7
Authors
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Authors Affiliations
  1. 1. School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Department of Cell Systems and Anatomy, UT Health. Long School of Medicine, San Antonio, TX, United States
  5. 5. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Internal Medicine, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  7. 7. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

Source: Pathology Research and Practice Published:2024


Abstract

Combination chemotherapy appears to be a preferable option for some cancer patients, especially when the medications target multiple pathways of oncogenesis; individuals treated with combination treatments may have a better prognosis than those treated with single agent chemotherapy. However, research has revealed that this is not always the case, and that this technique may just enhance toxicity while having little effect on boosting the anticancer effects of the medications. Cisplatin (CDDP) is a chemotherapeutic medicine that is commonly used to treat many forms of cancer. However, it has major adverse effects such as cardiotoxicity, skin necrosis, testicular toxicity, and nephrotoxicity. Many research have been conducted to investigate the effectiveness of melatonin (MLT) as an anticancer medication. MLT operates in a variety of ways, including decreasing cancer cell growth, causing apoptosis, and preventing metastasis. We review the literature on the role of MLT as an adjuvant in CDDP-based chemotherapies and discuss how MLT may enhance CDDP's antitumor effects (e.g., by inducing apoptosis and suppressing metastasis) while protecting other organs from its adverse effects, such as cardio- and nephrotoxicity. © 2023 Elsevier GmbH
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