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The Effect of Omega-3 Supplementation on Serum Levels of Inflammatory Biomarkers and Albumin in Hemodialysis Patients: A Systematic Review and Meta-Analysis Publisher Pubmed



Dezfouli M1 ; Moeinzadeh F2 ; Taheri S2 ; Feizi A3
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Nephrology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Biostatistics and Epidemiology, School of health, Isfahan University of Medical Sciences Isfahan, Isfahan, Iran

Source: Journal of Renal Nutrition Published:2020


Abstract

This systematic review and meta-analysis were performed to evaluate the effect of omega-3 supplementation on serum levels of inflammatory biomarkers (C-reactive protein [CRP], high-sensitivity CRP [hs-CRP], tumor necrosis factor-alpha, interleukin-6) and albumin in patients on hemodialysis. A literature search was performed in MEDLINE, Cochrane Central Register of Controlled Trials, PubMed, EMBASE, Web of Science, and Google Scholar. Randomized controlled trials that evaluated the effect of omega-3 supplementation versus placebo were selected. Eight randomized controlled trials comprising 371 patients on hemodialysis were included. According to our results, omega-3 supplementation significantly decreased serum levels of CRP (standardized mean difference [SMD]: −1.95 mg/Dl; 95% confidence interval [CI]: −3.09, −0.80) and hs-CRP (SMD: −2.09; 95% CI: −3.62, −0.56) but did not significantly improve albumin (SMD: 0.91; 95% CI: −0.78, 2.59), tumor necrosis factor-alpha (SMD: −1.51; 95% CI: −3.24, 0.22), and interleukin-6 (SMD: 0.72, 95% CI: −0.56, 1.99). We concluded that omega-3 supplementation leads to a significant decrease in serum levels of CRP and hs-CRP. © 2019 National Kidney Foundation, Inc.
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