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The Effects of Omega-3 Fatty Acids Supplementation on Hemoglobin, Hematocrit, and Platelet Levels of Patients With Esrd Condition Undergoing Dialysis Publisher



Mahmoudi Z1 ; Roumi Z2 ; Askarpour SA3 ; Mousavi Z4 ; Shafaei H5 ; Valisoltani N6 ; Shapouri M7 ; Mirshafaei SR8 ; Mirzaee P6 ; Mobarakeh KA9 ; Taghavi Sufiani E5 ; Motiee Bijarpasi Z5 ; Motiei Z5 ; Khosravi M10 Show All Authors
Authors
  1. Mahmoudi Z1
  2. Roumi Z2
  3. Askarpour SA3
  4. Mousavi Z4
  5. Shafaei H5
  6. Valisoltani N6
  7. Shapouri M7
  8. Mirshafaei SR8
  9. Mirzaee P6
  10. Mobarakeh KA9
  11. Taghavi Sufiani E5
  12. Motiee Bijarpasi Z5
  13. Motiei Z5
  14. Khosravi M10
  15. Doaei S11
  16. Gholamalizadeh M12
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Nutrition, Electronic Health and Statistics Surveillance Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. 3. Division of Food Safety and Hygiene, Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. School of Nursing and Midwifery Shahed University, Tehran, Iran
  5. 5. Department of Nursing, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran
  6. 6. Department of Medicine, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
  7. 7. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of applied mathematics, Roudsar and Amlash branch, Islamic Azad University, Roudsar, Iran
  9. 9. Department of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  10. 10. Urology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  11. 11. Department of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  12. 12. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Translational Autoimmunity Published:2024


Abstract

Background: Concomitant inflammation may boost the cardiovascular complications in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Omega-3 fatty acids may have certain health benefits in HD patients. The aim of this study was to investigate the effects of omega-3 fatty acids supplementation on hematocrit (HCT), hemoglobin (HB) level and platelet (PLT) counts of HD patients. Methods: A randomized controlled trial was conducted on HD patients at a private dialysis center in Rasht, Iran. Three omega-3 fatty acid supplement capsules (3 g/d) were administered daily for two months to patients in the intervention group (n = 55). The control group (n = 60) were given three placebo capsules containing medium chain triglyceride (MCT) oil, similar to the supplemental dose of the intervention group at the same period. Three parameters of HCT, HB and PLT were measured at baseline and after the intervention. Results: The PLT count decreased in the intervention group compared to the control group (173.38 ± 74.76 vs. 227.68 ± 86.58 103/mm3, F = 4.83, P = 0.03). No significant change was found on the levels of HCT and HB parameters between the two groups after the intervention. Conclusion: Omega-3 supplementation in HD patients may decrease the risk of forming blood clots in the blood vessels. Further studies are warranted. © 2024 The Authors
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