Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Interactions of Spontaneous Abortion With Fto Gene and Dietary Carotenoids; a Case-Control Study Publisher Pubmed



Amjadi A1 ; Abbasi Mobarakeh K2 ; Doaei S3, 4 ; Dorosti M5 ; Nami S6 ; Mirshafaei SR7 ; Mirshafaei MA8 ; Ataei Kachooei M9 ; Shamsigoushki A10 ; Saeedirad Z3 ; Azizi Tabesh G11 ; Khoshdooz S12 ; Abdollahi M13 ; Shekari S14 Show All Authors
Authors
  1. Amjadi A1
  2. Abbasi Mobarakeh K2
  3. Doaei S3, 4
  4. Dorosti M5
  5. Nami S6
  6. Mirshafaei SR7
  7. Mirshafaei MA8
  8. Ataei Kachooei M9
  9. Shamsigoushki A10
  10. Saeedirad Z3
  11. Azizi Tabesh G11
  12. Khoshdooz S12
  13. Abdollahi M13
  14. Shekari S14
  15. Gholamalizadeh M15
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Reproductive Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran
  5. 5. Student Research Committee, Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  6. 6. Department of Clinical Biochemistry, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Applied Mathematics, Roudsar and Amlash Branch, Islamic Azad University, Rudsar, Iran
  8. 8. Islamic Azad University, Tonekabon Mazandaran Branch, Tonekabon, Iran
  9. 9. Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  10. 10. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Department of Medical Genetics, School of Medicine, Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  12. 12. Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  13. 13. Social Determinants of Health Research Center, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  14. 14. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  15. 15. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Nutritional Science Published:2024


Abstract

Spontaneous abortion (SA) is considered one of the most prevalent adverse outcomes of pregnancy. SA may occur due to genetic susceptibility and various maternal factors such as nutritional status. The aim of this study was to assess how dietary carotenoids and the FTO gene are related to SA. This case-control study included 192 women with a history of SA as the case group and 347 healthy women without history of SA as the control group. To evaluate carotenoid intake, a valid 168-item food frequency questionnaire (FFQ) was used. The FTO gene was genotyped for the presence of the rs9939609 polymorphism using the tetra-primer amplification refractory mutation system-polymerase chain (ARMS-PCR). The results indicated a significant negative association between dietary intake of ß-cryptoxanthin and SA in carriers of the TT genotype of the FTO rs9939609 polymorphism after adjustment for age, BMI, physical activity, smoking, alcohol drinking, and calorie intake (ß = -0.28, P = 0.02). No association was found between SA with dietary intake of beta-carotene, alpha-carotene, lutein, and lycopene among carriers of different FTO genotypes. The FTO genotype may have an effect on the association between SA and carotenoid intake. Dietary intake of ß-cryptoxanthin may act as a protective factor against SA only in carriers of the TT genotype of the FTO rs9939609 polymorphism. © The Author(s), 2024.
Related Docs
View other Related Docs
1. The Interactions of Spontaneous Abortion, Dietary Intake of Selenium, and Fat Mass and Obesity Associated (Fto) Genotype: A Case-Control Study in Iran, Frontiers in Nutrition (2024)
2. Study of Association Between Factor Xi Polymorphism and Recurrent Miscarriage in Iran Helal Infertility Center (Rouyesh) Patients, Journal of Payavard Salamat (2019)
3. The Association Between Major Dietary Patterns and Pregnancy-Related Complications, Archives of Iranian Medicine (2018)
4. Genetic Variation in Salt Taste Receptors Impact Salt Intake and Blood Pressure, Scientific Reports (2023)
5. Patterns of Nutrient Intake in Relation to Gastric Cancer: A Case Control Study, Nutrition and Cancer (2022)
6. Relative Frequency of Thyroid Disorders in Pregnant Women at a Maternity Clinic in Isfahan, Iran, Journal of Isfahan Medical School (2012)
7. Associations Between Fto Rs9939609 Polymorphism, Serum Vitamin D, Mental Health, and Eating Behaviors in Overweight Adults, Nutritional Neuroscience (2022)
8. Factor Vii R353q (Rs6046), Fga A6534g (Rs6050), and Fgg C10034t (Rs2066865) Gene Polymorphisms and Risk of Recurrent Pregnancy Loss in Iranian Women, Indian Journal of Hematology and Blood Transfusion (2024)
Experts (# of related papers)
View all Related Experts
Awat Feizi (4)
Roya Kelishadi (3)
Other Related Docs
9. Survey of Pregnacy Induced Hypertention in Pregnant Women in Isfahan University of Medical Sciences Hospitals, Journal of Isfahan Medical School (2011)
10. The Effect of Fto Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Fiber, Frontiers in Nutrition (2022)
11. Comparison of Taqman Real-Time and Tetra-Primer Arms Pcr Techniques for Genotyping of Rs 8066560 Variant in Children and Adolescents With Metabolic Syndrome, Advances in Clinical and Experimental Medicine (2015)
12. The Association Between Dietary Glycemic Index and Load and Risk of Gestational Diabetes Mellitus: A Prospective Study, Diabetes Research and Clinical Practice (2020)
13. Dietary Patterns Among Pregnant Women in the West-North of Iran, Pakistan Journal of Biological Sciences (2008)
14. Role of Dietary Antioxidants and Vitamins Intake in Semen Quality Parameters: A Cross-Sectional Study, Clinical Nutrition ESPEN (2022)
15. Role of Rs9939506 Polymorphism of Fto Gene in Resistance to Eating in Male Adolescents, BMC Pediatrics (2023)
16. Determining the Association of Thrombophilic Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women, Gynecological Endocrinology (2020)
17. Thyroid-Stimulating Hormone (Tsh) Serum Levels and Risk of Spontaneous Abortion: A Prospective Population-Based Cohort Study, Clinical Endocrinology (2019)
18. The Relationship Between Major Dietary Patterns and Fertility Status in Iranian Men: A Case–Control Study, Scientific Reports (2021)
19. Association Between Maternal Plasma Total Antioxidant Capacity and Dietary Antioxidants Intake With Birth Size Outcomes, Journal of Tropical Pediatrics (2023)
20. Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different Fto Genotypes, Endocrinology, Diabetes and Metabolism (2024)
21. Significant Association Between Nonsyndromic Cleft Lip With or Without Cleft Palate and Irf6rs2235371 Polymorphism in Iranian Familiar Population, Molecular Biology (2015)
22. Joint Effects of Dietary Patterns and Paraoxonase1 Rs662 Polymorphism on Coronary Artery Disease Severity (Gensini and Syntax Scores) and Its Risk Factors in Adults Undergoing Angiography, Molecular Nutrition and Food Research (2024)
23. The Association Between Dietary Antioxidants and Semen Parameters: A Cross-Sectional Study Among Iranian Infertile Men, Biological Trace Element Research (2022)
24. The Results of Pregnancies After Gender Selection by Pre Implantation Genetic Diagnosis and Its Relation With Couple's Age, Iranian Journal of Nursing and Midwifery Research (2015)
25. Association of Dietary Patterns During Pregnancy and Cord Blood Nitric Oxide Level With Birth Weight of Newborns, International Journal of Pediatrics (2017)
26. The Association Between Non-Enzymatic Dietary Total Antioxidant Capacity and Phytochemical Index With Semen Parameters: A Cross-Sectional Study in Isfahan Infertile Men, Journal of Nutrition and Food Security (2022)
27. The Effects of Fto Gene Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Intake, Frontiers in Nutrition (2023)
28. Dietary Patterns and the Outcomes of Assisted Reproductive Techniques in Women With Primary Infertility: A Prospective Cohort Study, International Journal of Fertility and Sterility (2019)
29. Does Dietary Intake of Vitamin a and Beta-Carotene Increase the Risk of Hypertension?, Cardiovascular Endocrinology and Metabolism (2024)
30. Significant Association Between Nonsyndromic Cleft Lip With or Without Cleft Palate and Irf6rs2235371 Polymorphism in Iranian Familiar Population, Molekuliarnaia biologiia (2015)