Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Interactions of Spontaneous Abortion, Dietary Intake of Selenium, and Fat Mass and Obesity Associated (Fto) Genotype: A Case-Control Study in Iran Publisher



Nooriani N1 ; Saeedirad Z2 ; Shekari S3 ; Nami S4 ; Mahmoudi Z3 ; Abbasi Mobarakeh K5 ; Adabi SB6 ; Khodarahmi S7, 8 ; Bahmani P9 ; Doaei S9, 10 ; Ajami M11 ; Gholamalizadeh M12
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  4. 4. Department of Clinical Biochemistry, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Student Research Committee, Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  7. 7. School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran
  9. 9. Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Reproductive Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran
  11. 11. Department of Food and Nutrition Policy and Planning, School of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  12. 12. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Frontiers in Nutrition Published:2024


Abstract

Background: Spontaneous abortion (SA) is reported to be associated with Fat Mass And Obesity-Associated FTO genotype and dietary intake of selenium. This research assessed the potential interactions between the risk of SA, dietary selenium intake, and the FTO rs9939609 polymorphism. Methods: This case-control study encompassed 192 women who experienced SA and 347 control participants. Dietary selenium intake was evaluated using a comprehensive food frequency questionnaire (FFQ) and Nutritionist IV software. The FTO gene was genotyped for rs9939609 polymorphism. Result: The findings showed that there were no significant variations in the case and control groups’ dietary selenium intake. A lower selenium intake was inversely associated with SA only among individuals with the TT genotype of the FTO gene (β = −0.19, p = 0.04). The results remained unchanged when age, BMI, physical activity, smoking, alcohol consumption, and calorie intake were taken into account. Conclusion: A link may exist between selenium consumption and SA, especially in individuals with the TT genotype in the FTO gene. These findings underline the influence of genetic factors on how dietary intake impacts SA. Further investigation is required to validate these conclusions. Copyright © 2024 Nooriani, Saeedirad, Shekari, Nami, Mahmoudi, Abbasi Mobarakeh, Adabi, Khodarahmi, Bahmani, Doaei, Ajami and Gholamalizadeh.
Related Docs
View other Related Docs
1. Interactions of Spontaneous Abortion With Fto Gene and Dietary Carotenoids; a Case-Control Study, Journal of Nutritional Science (2024)
2. Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different Fto Genotypes, Endocrinology, Diabetes and Metabolism (2024)
3. The Effects of Fto Gene Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Intake, Frontiers in Nutrition (2023)
4. Anti-Thyroid Antibodies and Underlying Generalized Immunologic Aberrations in Patients With Reproductive Failures, Journal of Reproductive Immunology (2022)
5. Study of Association Between Factor Xi Polymorphism and Recurrent Miscarriage in Iran Helal Infertility Center (Rouyesh) Patients, Journal of Payavard Salamat (2019)
6. The Effects of Selenium Supplementation on Blood Lipids and Blood Pressure in Adults: A Systematic Review and Dose-Response Meta-Analysis of Randomized Control Trials, Journal of Trace Elements in Medicine and Biology (2022)
7. Associations Between Fto Rs9939609 Polymorphism, Serum Vitamin D, Mental Health, and Eating Behaviors in Overweight Adults, Nutritional Neuroscience (2022)
8. Association of Single Nucleotide Polymorphisms in the First Intron of the Fat Mass and Obesity Associated (Fto) Gene With Obesity Risk in Asians: A Meta-Analysis, Progress in Nutrition (2019)
Experts (# of related papers)
View all Related Experts
Masoumeh Sadeghi (3)
Mohammad Bagherniya (2)
Other Related Docs
9. Survey of Pregnacy Induced Hypertention in Pregnant Women in Isfahan University of Medical Sciences Hospitals, Journal of Isfahan Medical School (2011)
10. The Effect of Fto Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Fiber, Frontiers in Nutrition (2022)
11. The Association Between Blood Selenium and Metabolic Syndrome in Adults: A Systematic Review and Dose–Response Meta-Analysis of Epidemiologic Studies, Frontiers in Nutrition (2024)
12. Association of Expression of Selenoprotein P in Mrna and Protein Levels With Metabolic Syndrome in Subjects With Cardiovascular Disease: Results of the Selenegene Study, Journal of Gene Medicine (2017)
13. The Association Between Serum Selenium and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis, Journal of Trace Elements in Medicine and Biology (2015)
14. Fto Genotype Was Associated With Breast Cancer in Her2 Negative Patients, Clinical Nutrition ESPEN (2022)
15. Lipid Regulatory Genes Polymorphism in Children With and Without Obesity and Cardiometabolic Risk Factors: The Caspian-Iii Study, Journal of Research in Medical Sciences (2018)
16. Role of Rs9939506 Polymorphism of Fto Gene in Resistance to Eating in Male Adolescents, BMC Pediatrics (2023)
17. Determining the Association of Thrombophilic Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women, Gynecological Endocrinology (2020)
18. Selenium Homeostasis and Clustering of Cardiovascular Risk Factors: A Systematic Review, Acta Biomedica (2017)
19. Effect of Single Nucleotide Polymorphisms in Seps1 and Sepp1 on Expression in the Protein Level in Metabolic Syndrome in Subjects With Cardiovascular Disease, Molecular Biology Reports (2019)
20. Effect of Selenium Supplementation on Glucose Homeostasis and Lipid Profile in Women With Metabolic Syndrome: Randomized, Double-Blind, Placebo-Controlled Trial, Journal of Health System Research (2021)
21. Effects of Selenium Supplementation on Glucose Homeostasis, Inflammation, and Oxidative Stress in Gestational Diabetes: Randomized, Double-Blind, Placebo-Controlled Trial, Nutrition (2015)
22. Serum Selenium Levels and Lipid Profile: A Systematic Review and Meta-Analysis of Observational Studies, Biological Trace Element Research (2024)
23. Variants in the Ppargc1a Gene May Influence the Effect of Fat Intake on Resting Metabolic Rate in Obese Women, Lipids (2018)
24. Selenium Supplementation Effect on Glycemic Control: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2023)