Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Supramolecular Self-Assembled Nanogels a New Platform for Anticancer Drug Delivery Publisher Pubmed



Varshosaz J1 ; Taymouri S1 ; Ghassami E1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Current Pharmaceutical Design Published:2017


Abstract

Polymer micellar nanogels are a group of core-shell polymeric micelles with swelling properties in aqueous media. Nanogel systems have proven their potential in controlled, sustained and targetable drug delivery area with no immunological responses. This review includes a comprehensive wide range of self-assembly of polymeric nanogels as delivery systems for anticancer drugs. Nanogels are nanoparticulate drug delivery systems which are specially designed for enhanced target oriented and cellular uptake of drugs with emphasis on chemotherapeutic agents studied in this review. Self-assembling nanogels are based on natural substances or synthetic polymers including: hyaluronic acid, heparin, alginate, cyclodextrins, chondroeitin sulfate, starch, mannan, chitosan, pullulan, poly(N-isopropylacrylamide), polyvynil alcohol, Pluronic F127, polyacrylic acid, poly(hydroxylethyl methacrylate), poly[2- (dimethylamino)ethyl methacrylate and polylactide-co-glycolide-polyethylen glycol amphiphilic di or tri block copolymer used to deliver anticancer drugs are introduced and discussed. © 2017 Bentham Science Publishers.
Related Docs
View other Related Docs
1. Novel Ph-Triggered Biocompatible Polymeric Micelles Based on Heparin–Α-Tocopherol Conjugate for Intracellular Delivery of Docetaxel in Breast Cancer, Pharmaceutical Development and Technology (2020)
2. In Vitro and in Vivo Evaluation of Novel Dtx-Loaded Multifunctional Heparin-Based Polymeric Micelles Targeting Folate Receptors and Endosomes, Recent Patents on Anti-Cancer Drug Discovery (2020)
3. Smart Redox-Sensitive Micelles Based on Chitosan for Dasatinib Delivery in Suppressing Inflammatory Diseases, International Journal of Biological Macromolecules (2023)
4. Redox Sensitive Polysaccharide Based Nanoparticles for Improved Cancer Treatment: A Comprehensive Review, Current Pharmaceutical Design (2018)
5. Synthesis and in Vitro/In Vivo Characterization of Raloxifene Grafted Poly(Styrene Maleic Acid)-Poly(Amide-Ether-Ester-Imide) Micelles for Targeted Delivery of Docetaxel in G Protein-Coupled Estrogen Receptor Breast Cancer, Anti-Cancer Agents in Medicinal Chemistry (2018)
6. Preparation and Characterization of an Injectable Thermosensitive Hydrogel for Simultaneous Delivery of Paclitaxel and Doxorubicin, Research in Pharmaceutical Sciences (2018)
7. Methotrexate-Grafted-Oligochitosan Micelles As Drug Carriers: Synthesis and Biological Evaluations, Journal of Materials Science: Materials in Medicine (2015)
8. Synthesis, in Vitro Characterization, and Anti-Tumor Effects of Novel Polystyrene-Poly(Amide-Ether-Ester-Imide) Co-Polymeric Micelles for Delivery of Docetaxel in Breast Cancer in Balb/C Mice, Drug Development and Industrial Pharmacy (2018)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (88)
Farshid Hassanzadeh (40)
Other Related Docs
9. Physicochemical, Pharmaceutical and Biological Approaches Toward Designing Optimized and Efficient Hydrophobically Modified Chitosan-Based Polymeric Micelles As a Nanocarrier System for Targeted Delivery of Anticancer Drugs, Journal of Drug Targeting (2013)
10. Pegylated Multifunctional Ph-Responsive Targeted Polymeric Micelles for Ovarian Cancer Therapy: Synthesis, Characterization and Pharmacokinetic Study, International Journal of Polymeric Materials and Polymeric Biomaterials (2021)
11. An Injectable Thermosensitive Hydrogel/Nanomicelles Composite for Local Chemo-Immunotherapy in Mouse Model of Melanoma, Journal of Biomaterials Applications (2022)
12. Folated Synperonic-Cholesteryl Hemisuccinate Polymeric Micelles for the Targeted Delivery of Docetaxel in Melanoma, BioMed Research International (2015)
13. Boron Phenyl Alanine Targeted Ionic Liquid Decorated Chitosan Nanoparticles for Mitoxantrone Delivery to Glioma Cell Line, Pharmaceutical Development and Technology (2021)
14. Antitumor Activity of Raloxifene-Targeted Poly(Styrene Maleic Acid)-Poly (Amide-Ether-Ester-Imide) Co-Polymeric Nanomicelles Loaded With Docetaxel in Breast Cancer-Bearing Mice, Investigational New Drugs (2018)
15. Retinoic Acid Decorated Albumin-Chitosan Nanoparticles for Targeted Delivery of Doxorubicin Hydrochloride in Hepatocellular Carcinoma, Journal of Nanomaterials (2013)
16. Folic Acid Targeted Polymeric Micelles Based on Tocopherol Succinate-Pulluan As an Effective Carrier for Epirubicin: Preparation, Characterization and In-Vitro Cytotoxicity Assessment, Current Drug Delivery (2018)
17. Poly (Ethylene-Co-Vinyl Alcohol)-Based Polymeric Thermo-Responsive Nanocarriers for Controlled Delivery of Epirubicin to Hepatocellular Carcinoma, Research in Pharmaceutical Sciences (2017)
18. Novel Worm-Like Amphiphilic Micelles of Folate-Targeted Cyclodextrin/Retinoic Acid for Delivery of Doxorubicin in Kg-1 Cells, Colloid and Polymer Science (2014)
19. Optimisation of Processing Variables Effective on Self-Assembly of Folate Targeted Synpronic-Based Micelles for Docetaxel Delivery in Melanoma Cells, IET Nanobiotechnology (2015)
20. Development and in Vitro/In Vivo Evaluation of Hpmc/Chitosan Gel Containing Simvastatin Loaded Self-Assembled Nanomicelles As a Potent Wound Healing Agent, Drug Development and Industrial Pharmacy (2018)
21. Pharmacokinetics and in Vitro/In Vivo Antitumor Efficacy of Aptamer-Targeted Ecoflex® Nanoparticles for Docetaxel Delivery in Ovarian Cancer, International Journal of Nanomedicine (2018)
22. Biotin-Encoded Pullulan-Retinoic Acid Engineered Nanomicelles: Preparation, Optimization and in Vitro Cytotoxicity Assessment in Mcf-7 Cells, Indian Journal of Pharmaceutical Sciences (2016)
23. Plga-Peg-Ra-Based Polymeric Micelles for Tumor Targeted Delivery of Irinotecan, Pharmaceutical Development and Technology (2018)
24. Fabrication of Poly Hydroxybutyrate-Polyethylene Glycol-Folic Acid Nanoparticles Loaded by Paclitaxel, Current Drug Delivery (2016)
25. Polyacrylamide-Punicic Acid Conjugate-Based Micelles for Flutamide Delivery in Pc3 Cells of Prostate Cancer: Synthesis, Characterisation and Cytotoxicity Studies, IET Nanobiotechnology (2020)
26. Biodegradable Nanocarriers Based on Chitosan-Modified Mesoporous Silica Nanoparticles for Delivery of Methotrexate for Application in Breast Cancer Treatment, Materials Science and Engineering C (2021)
27. Preparation and Characterization of Itraconazole Loaded Nanomicelles Based on Dextran–Behenic Acid for Cutaneous Leishmaniasis Treatment, Drug Development and Industrial Pharmacy (2021)
28. Polymeric Nanoparticles in Cancer Chemotherapy: A Narrative Review, Iranian Journal of Public Health (2022)
29. Preparation and Characterization of Spray-Dried Inhalable Powders Containing Polymeric Micelles for Pulmonary Delivery of Paclitaxel in Lung Cancer, Journal of Pharmacy and Pharmaceutical Sciences (2018)
30. Peptide-Functionalized Polymeric Nanoparticles for Delivery of Curcumin to Cancer Cells, Journal of Drug Delivery Science and Technology (2024)
31. Novel Ngr Anchored Pullulan Micelles for Controlled and Targeted Delivery of Doxorubicin to Hela Cancerous Cells, Iranian Polymer Journal (English Edition) (2018)
32. Assessment of Ph Responsive Delivery of Methotrexate Based on Phema-St-Peg-Da Nanohydrogels, Macromolecular Research (2021)
33. Self-Assembly Micelles With Lipid Core of Cholesterol for Docetaxel Delivery to B16f10 Melanoma and Hepg2 Cells, Journal of Liposome Research (2015)
34. Peptide-Based Pegylated Polyurethane Nanoparticles for Paclitaxel Delivery in Hela Cancer Cells: The Art of the Architecture Design in Nanocarriers, Polymer Bulletin (2023)
35. Pharmacokinetics, Organ Toxicity and Antitumor Activity of Docetaxel Loaded in Folate Targeted Cholesterol Based Micelles, Current Drug Delivery (2016)
36. An Injectable Carboxymethyl Chitosan-Methylcellulose-Pluronic Hydrogel for the Encapsulation of Meloxicam Loaded Nanoparticles, International Journal of Biological Macromolecules (2020)
37. Enhancement in Biological Activity of L-Asparginase by Its Conjugation on Silica Nanoparticles, Recent Patents on Nanotechnology (2018)
38. Dendrimers As Nanoscale Vectors: Unlocking the Bars of Cancer Therapy, Seminars in Cancer Biology (2022)
39. Poly(Glycerol Sebacate) Nanoparticles for Ocular Delivery of Sunitinib: Physicochemical, Cytotoxic and Allergic Studies, IET Nanobiotechnology (2019)
40. Development and Optimization of Transferrin-Conjugated Nanostructured Lipid Carriers for Brain Delivery of Paclitaxel Using Box–Behnken Design, Pharmaceutical Development and Technology (2017)
41. Nanoparticles for Targeted Delivery of Therapeutics and Small Interfering Rnas in Hepatocellular Carcinoma, World Journal of Gastroenterology (2015)
42. Ciprofloxacin Loaded Alginate/Chitosan and Solid Lipid Nanoparticles, Preparation, and Characterization, Journal of Dispersion Science and Technology (2012)
43. Dialdehyde Carbohydrates – Advanced Functional Materials for Biomedical Applications, Carbohydrate Polymers (2023)
44. Magnetic Polyvinyl Caprolactam–Polyvinyl Acetate–Polyethylene Glycol Micelles for Docetaxel Delivery in Breast Cancer: An in Vitro Study on Two Cell Lines of Breast Cancer, Pharmaceutical Development and Technology (2017)
45. Boron Phenyl Alanine Targeted Chitosan–Pnipaam Core–Shell Thermo-Responsive Nanoparticles: Boosting Drug Delivery to Glioblastoma in Bnct, Drug Development and Industrial Pharmacy (2021)
46. Protein-Polysaccharide Interactions for the Fabrication of Bioactive-Loaded Nanocarriers: Chemical Conjugates and Physical Complexes, Pharmacological Research (2022)
47. Evaluation of Lipid Nanocarriers in the Form of Sln and Their Application in Drug Delivery, Nanochemistry Research (2023)
48. Design, Synthesis, and Comparison of Pla-Peg-Pla and Peg-Pla-Peg Copolymers for Curcumin Delivery to Cancer Cells, Polymers (2023)
49. Synthesis and Characterization of Folate-Targeted Dextran/Retinoic Acid Micelles for Doxorubicin Delivery in Acute Leukemia, BioMed Research International (2014)
50. Development and Optimization of Solid Lipid Nanoparticles of Amikacin by Central Composite Design, Journal of Liposome Research (2010)