Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Smart Redox-Sensitive Micelles Based on Chitosan for Dasatinib Delivery in Suppressing Inflammatory Diseases Publisher Pubmed



Vakilzadeh H1 ; Varshosaz J1 ; Dinari M2 ; Mirian M3 ; Hajhashemi V4 ; Shamaeizadeh N1 ; Sadeghi HMM3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Chemistry, Isfahan University of Technology, Isfahan, Iran
  3. 3. Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Pharmacology, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Biological Macromolecules Published:2023


Abstract

Dasatinib (DAS) exhibits anti-inflammatory effects by retrieving the balance between inflammatory and anti-inflammatory cytokines secreted by macrophages. The aim of this study was the development of redox-responsive micelles with the potential of passive targeting and on-demand drug release for DAS delivery to macrophages. For this purpose, two molecular weights of chitosan (CHIT) were conjugated to DAS at different molar ratios using 3,3′-dithiodipropionic anhydride (DTDPA) as disulfide bond containing linker to synthesize a series of CHIT-S-S-DAS amphiphilic conjugates. Micelles obtained by the sonication method had particle sizes of 129.3–172.2 nm, zeta potentials of +17.5 to +20.9 mV, drug contents of 0.90–7.20 %, CMC values of 35.3–96.6 μg/ml, and exhibited redox-responsive in vitro drug release. Optimized micelles were non-toxic and dramatically more efficient than non-redox responsive micelles in reducing TNF-α and IL-6 and increasing IL-10 secretion from LPS-stimulated RAW264.7 cells. Furthermore, the redox-responsive micelles were able to reduce the mice paw edema, reduce the plasma levels of pro-inflammatory cytokines and increase plasma level of IL-10, considerably more than free DAS and non-redox responsive micelles in carrageenan-induced mice paw edema model of inflammation. © 2022
Related Docs
View other Related Docs
1. Co-Delivery of Interferon Regulatory Factor 5 (Irf5) Sirna and Dasatinib by a Disulfide Bond Bearing Polymeric Carrier for Enhanced Anti-Inflammatory Effects, International Journal of Biological Macromolecules (2024)
2. Physicochemical, Pharmaceutical and Biological Approaches Toward Designing Optimized and Efficient Hydrophobically Modified Chitosan-Based Polymeric Micelles As a Nanocarrier System for Targeted Delivery of Anticancer Drugs, Journal of Drug Targeting (2013)
3. Supramolecular Self-Assembled Nanogels a New Platform for Anticancer Drug Delivery, Current Pharmaceutical Design (2017)
4. Anti Her-2 Aptamer Functionalized Gold Nanoparticles of Dasatinib for Targeted Chemo-Radiotherapy in Breast Cancer Cells, Biomaterials Advances (2023)
5. Elucidation of Molecular Mechanisms Behind the Self-Assembly Behavior of Chitosan Amphiphilic Derivatives Through Experiment and Molecular Modeling, Pharmaceutical Research (2015)
6. Development and in Vitro/In Vivo Evaluation of a Novel Targeted Polymeric Micelle for Delivery of Paclitaxel, International Journal of Biological Macromolecules (2015)
7. Co-Delivery of Paclitaxel and Α-Tocopherol Succinate by Novel Chitosan-Based Polymeric Micelles for Improving Micellar Stability and Efficacious Combination Therapy, Drug Development and Industrial Pharmacy (2015)
8. Methotrexate-Grafted-Oligochitosan Micelles As Drug Carriers: Synthesis and Biological Evaluations, Journal of Materials Science: Materials in Medicine (2015)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (62)
Farshid Hassanzadeh (37)
Other Related Docs
9. Targeted Nanostructured Lipid Carriers for Delivery of Paclitaxel to Cancer Cells: Preparation, Characterization, and Cell Toxicity, Current Drug Delivery (2017)
10. Polydopamine Coated Surfactin Micelles for Brain Delivery of Ibudilast in Multiple Sclerosis: Design, Optimization, in Vitro and in Vivo Evaluation, Journal of Drug Delivery Science and Technology (2024)
11. Boron Phenyl Alanine Targeted Ionic Liquid Decorated Chitosan Nanoparticles for Mitoxantrone Delivery to Glioma Cell Line, Pharmaceutical Development and Technology (2021)
12. Insights Into Whey Protein-Based Carriers for Targeted Delivery and Controlled Release of Bioactive Components, Food Hydrocolloids (2022)
13. Hyaluronic Acid Targeted Metal Organic Framework Based on Iron (Iii) for Delivery of Platinum Curcumin Cytotoxic Agent to Triple Negative Breast Cancer Cell Line, Applied Organometallic Chemistry (2022)
14. Folated Synperonic-Cholesteryl Hemisuccinate Polymeric Micelles for the Targeted Delivery of Docetaxel in Melanoma, BioMed Research International (2015)
15. Co-Delivery of Dasatinib and Mir-30A by Liposomes Targeting Neuropilin-1 Receptors for Triple-Negative Breast Cancer Therapy, Journal of Materials Chemistry B (2024)
16. Transferrin-Targeted Poly(Butylene Adipate)/Terephthalate Nanoparticles for Targeted Delivery of 5-Fluorouracil in Ht29 Colorectal Cancer Cell Line, Journal of Bioactive and Compatible Polymers (2017)
17. An Injectable Carboxymethyl Chitosan-Methylcellulose-Pluronic Hydrogel for the Encapsulation of Meloxicam Loaded Nanoparticles, International Journal of Biological Macromolecules (2020)
18. Retinoic Acid-Oligomeric Chitosan Micelles As Novel Gene Delivery Carrier; in Vitro Transfection Study, Journal of Reports in Pharmaceutical Sciences (2013)
19. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
20. Plga-Peg-Ra-Based Polymeric Micelles for Tumor Targeted Delivery of Irinotecan, Pharmaceutical Development and Technology (2018)
21. Recent Progress in Cancer Immunotherapy: Application of Nano-Therapeutic Systems, Journal of Drug Delivery Science and Technology (2024)
22. Feasibility of Haloperidol-Anchored Albumin Nanoparticles Loaded With Doxorubicin As Dry Powder Inhaler for Pulmonary Delivery, Pharmaceutical Development and Technology (2015)
23. Dendrimers As Nanoscale Vectors: Unlocking the Bars of Cancer Therapy, Seminars in Cancer Biology (2022)
24. Preparation and Evaluation of Imatinib Loaded Transfersomal Gel for the Treatment of Rheumatoid Arthritis, Iranian Journal of Pharmaceutical Research (2021)
25. Biotin-Encoded Pullulan-Retinoic Acid Engineered Nanomicelles: Preparation, Optimization and in Vitro Cytotoxicity Assessment in Mcf-7 Cells, Indian Journal of Pharmaceutical Sciences (2016)
26. Ciprofloxacin Loaded Alginate/Chitosan and Solid Lipid Nanoparticles, Preparation, and Characterization, Journal of Dispersion Science and Technology (2012)
27. An Injectable Thermosensitive Hydrogel/Nanomicelles Composite for Local Chemo-Immunotherapy in Mouse Model of Melanoma, Journal of Biomaterials Applications (2022)
28. Protein-Polysaccharide Interactions for the Fabrication of Bioactive-Loaded Nanocarriers: Chemical Conjugates and Physical Complexes, Pharmacological Research (2022)
29. Camouflaged Liposomes by 11A4-Nanobody for Co-Delivery of Cisplatin and Nitroxoline in Breast Cancer Tumors: An in Vitro/In Vivo Study, Journal of Drug Delivery Science and Technology (2022)
30. Pegylated Multifunctional Ph-Responsive Targeted Polymeric Micelles for Ovarian Cancer Therapy: Synthesis, Characterization and Pharmacokinetic Study, International Journal of Polymeric Materials and Polymeric Biomaterials (2021)
31. Evaluation of Lipid Nanocarriers in the Form of Sln and Their Application in Drug Delivery, Nanochemistry Research (2023)
32. Docetaxel-Loaded Nanostructured Lipid Carriers Functionalized With Trastuzumab (Herceptin) for Her2-Positive Breast Cancer Cells, Journal of Liposome Research (2018)
33. Synthesis and Characterization of Folate-Targeted Dextran/Retinoic Acid Micelles for Doxorubicin Delivery in Acute Leukemia, BioMed Research International (2014)
34. Preparation and Characterization of Micelles of Oligomeric Chitosan Linked to All-Trans Retinoic Acid, Carbohydrate Polymers (2012)
35. Biological Safety Evaluation of Stealth Solid Lipid Nanoparticles of Risperidone: Effect of Surface Characteristics on Their Hydrophobicity, Haemolysis and Macrophage Phagocytosis, Farmacia (2012)
36. Graphene Oxide Quantum Dot-Chitosan Nanotheranostic Platform As a Ph-Responsive Carrier for Improving Curcumin Uptake Internalization: In Vitro & in Silico Study, Biomaterials Advances (2022)
37. Peptide-Based Pegylated Polyurethane Nanoparticles for Paclitaxel Delivery in Hela Cancer Cells: The Art of the Architecture Design in Nanocarriers, Polymer Bulletin (2023)
38. Design and Optimization of Alginate-Chitosan-Pluronic Nanoparticles As a Novel Meloxicam Drug Delivery System, Journal of Applied Polymer Science (2015)
39. Synthesis of Biotin-Targeted Chitosan/Poly (Methyl Vinyl Ether- Alt -Maleic Acid) Copolymeric Micelles for Delivery of Doxorubicin, IET Nanobiotechnology (2017)
40. Recent Progresses in the Delivery of Β-Carotene: From Nano/Microencapsulation to Bioaccessibility, Advances in Colloid and Interface Science (2022)
41. How Do Various Encapsulation Techniques Improve the Oral Delivery of Food Protein Hydrolysates?, Food Frontiers (2025)
42. Cytotoxic Effects of Targeted Galactosylated Pluronic F127/Pluronicl122 Nano-Sized Micelles Loaded With Doxorubicin in Human Hepatocellular Carcinoma Cell Line, Journal of Isfahan Medical School (2013)
43. Pharmaceutical Evaluation of Atorvastatin-Loaded Nanostructured Lipid Carriers Incorporated Into the Gelatin/Hyaluronic Acid/Polycaprolactone Scaffold for the Skin Tissue Engineering, Journal of Biomaterials Applications (2021)
44. Evaluation of Thermosensitive Chitosan Hydrogel Containing Gefitinib Loaded Cellulose Acetate Butyrate Nanoparticles in a Subcutaneous Breast Cancer Model, International Journal of Pharmaceutics (2022)
45. Cytotoxic Effect of Pluronic F127-Poly (Methyl Vinyl Ether-Alt-Maleic Acid) Micelles Loaded With Doxorubicin on Mcf-7 Cells, Journal of Isfahan Medical School (2013)
46. Biotin Decorated Sunitinib Loaded Nanostructured Lipid Carriers for Tumor Targeted Chemotherapy of Lung Cancer, Journal of Drug Delivery Science and Technology (2019)
47. Tissue Distribution and Systemic Toxicity Evaluation of Raloxifene Targeted Polymeric Micelles of Poly (Styrene-Maleic Acid)-Poly (Amide- Ether-Ester-Imide)-Poly (Ethylene Glycol) Loaded With Docetaxel in Breast Cancer Bearing Mice, Recent Patents on Anti-Cancer Drug Discovery (2019)
48. Fluorescence Resonance Energy Transfer Monitoring of Ph-Responsive Doxorubicin Release From Carbon Dots/Aptamer Functionalized Magnetic Mesoporous Silica, Nanomedicine (2021)
49. Biodegradable and Biocompatible Subcutaneous Implants Consisted of Ph-Sensitive Mebendazole-Loaded/Folic Acid-Targeted Chitosan Nanoparticles for Murine Triple-Negative Breast Cancer Treatment, Journal of Nanobiotechnology (2022)
50. Folate Targeted Solid Lipid Nanoparticles of Simvastatin for Enhanced Cytotoxic Effects of Doxorubicin in Chronic Myeloid Leukemia, Current Nanoscience (2012)