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Animal Protein Intake Is Directly Associated With Serum Level of Pentraxin 3 in Hemodialysis Patients Publisher Pubmed



Navab F1 ; Foshati S2 ; Bagherniya M1 ; Askari G1 ; Moeinzadeh F3 ; Gholaminejad A4 ; Clark CCT5 ; Rouhani MH1
Authors
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Authors Affiliations
  1. 1. Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Regenerative Medicine Research Center, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Centre for Intelligent Healthcare, Coventry University, Coventry, CV1 5FB, United Kingdom

Source: Scientific Reports Published:2023


Abstract

Inflammation plays an important role in Cardiovascular disease (CVD) pathogenesis as the main cause of mortality in hemodialysis (HD) patients. Despite the relevance of nutrition and dietary intakes for inflammation status, the role of dietary protein sources remains unclear. The aim of this study was to evaluate the association between the different types of dietary protein and pentraxin 3 (PTX3) levels in HD patients. In this multi-center cross-sectional study, 227 adult patients undergoing HD for a minimum 90 days were recruited. A validated 168-item food frequency questionnaire was used to assess dietary intakes. Also, 5 ml blood samples were collected from each patient to measure the concentration of serum PTX3. Overall, 227 patients, including 63 women and 164 men, with a mean age of 58 years, participated in this study. There was a greater intake of animal protein per kilogram dry weight among patients with higher levels of PTX3 (0.46 vs. 0.54 g/kg; P = 0.035). In contrast, consumption of total protein and plant protein per kilogram dry weight was not different across PTX3 levels. Moreover, the chance of increased PTX3 concentration was directly associated with a one-unit increase in animal protein intake per kilogram dry weight, after adjusting for confounders. We did not observe any association between one-unit increases in plant protein intake per kilogram dry weight and chance of increased PTX3. In conclusion, animal protein intake was directly associated with circulating PTX3. © 2023, The Author(s).
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