The Evaluation of Effects Two Different Doses of Hydrocortisone on the Intensity of Perioperative Shivering in Elective Surgery Under Spinal Anesthesia: A Double-Blind Randomized Controlled Trial Study Publisher



Safavi M¹ ; Honarmand A¹ ; Khosravi F¹ ; Sariazdi H¹ ; Nazem M² Show Affiliations
Source: Journal of Research in Medical Sciences Published:2016

Abstract

Background: Post- and intra-operative shivering is one of the most complications of spinal anesthesia so recommend a suitable drug with at least complications for prevention and control of postoperative shivering. This current study aimed to compare the preventive effect of hydrocortisone on intra- and post-operative shivering in patients undergoing surgery with spinal anesthesia. Materials and Methods: In a clinical trial study, ninety patients who candidate for surgery with spinal anesthesia were selected and randomly divided into three groups. The first and second groups were received 1 mg/kg and 2 mg/kg hydrocortisone, respectively, and the third group was received normal saline, and postoperative shivering was compared between the three groups. Results: The investigation of the incidence of inter- and post-operative shivering in patients in the three groups revealed that within the study period, 31 patients suffered from shivering among which 9, 5, and 17 cases were in 1 mg/kg hydrocortisone group, 2 mg/kg hydrocortisone group, and placebo group, respectively, and according to the Chi-square test, the difference among the three groups was significant (P = 0.004). Conclusion: According to the obtained results, the overall conclusion of the study is that using hydrocortisone at least with the dose of 1 mg/kg as a preventive drug reduced the incidence of intra-and post-operative shivering with spinal anesthesia. © 2016 Journal of Research in Medical Sciences.