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Effect of Aloe Vera Against Natural and Chemical Toxicities Publisher



Shirvanian K1 ; Naghizadeh M2 ; Vali R3 ; Farkhondeh T4 ; Pourbaghershahri AM4 ; Aschner M5 ; Ahmadian M6 ; Samarghandian S7
Authors
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Authors Affiliations
  1. 1. Department of Biology, Faculty of Pharmacy, University of Tehran, Tehran, Iran
  2. 2. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Biology, Faculty of Modern Sciences, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
  4. 4. Department of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran
  5. 5. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 209 1300 Morris Park Avenue, Bronx, NY, United States
  6. 6. General Practitioner, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran

Source: Current Nutrition and Food Science Published:2024


Abstract

Aloe vera (A. barbadensis, A. indica, and Aloe vulgaris) is a succulent plant native to the southeast Arabian Peninsula. Yet it’s been cultivated all over the world with widespread use in skin products due to its natural anti-inflammatory effects because it contains alkaline phosphatases, brady kinases, catalases, and antioxidant effects due to its high concentration of vitamin A and E. Aloe vera has shown some anti-TNF-α and anti-TGF-β properties as well. It also has anti-oxidative stress effects against many toxins. This review focuses on many in-vitro or in vivo studies on numerous toxins, either natural or synthetic, and the role that Aloe vera can play in ameliorating their effects. Aloe vera has consistently been shown to affect the MDA, GSH, and other reduction-oxidation pathways in the cell. It has been shown to improve cell-free radical scavenging applications and be a natural, safe, and cheap supplement to treat many toxins and toxicants. © 2024 Bentham Science Publishers.
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