Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Doxorubicin-Related Cardiotoxicity: Review of Fundamental Pathways of Cardiovascular System Injury Publisher Pubmed



Avagimyan A1 ; Pogosova N2, 3 ; Kakturskiy L4 ; Sheibani M5, 6 ; Challa A7 ; Kogan E8 ; Fogacci F9 ; Mikhaleva L4 ; Vandysheva R4 ; Yakubovskaya M10, 11 ; Faggiano A12, 13 ; Carugo S12, 13 ; Urazova O14 ; Jahanbin B15 Show All Authors
Authors
  1. Avagimyan A1
  2. Pogosova N2, 3
  3. Kakturskiy L4
  4. Sheibani M5, 6
  5. Challa A7
  6. Kogan E8
  7. Fogacci F9
  8. Mikhaleva L4
  9. Vandysheva R4
  10. Yakubovskaya M10, 11
  11. Faggiano A12, 13
  12. Carugo S12, 13
  13. Urazova O14
  14. Jahanbin B15
  15. Lesovaya E10, 11, 16
  16. Polana S17
  17. Kirsanov K10, 11
  18. Sattar Y7
  19. Trofimenko A18
  20. Demura T8
  21. Saghazadeh A15
  22. Koliakos G19
  23. Shafie D20
  24. Alizadehasl A21
  25. Cicero A22, 23
  26. Costabel JP24
  27. Biondizoccai G25, 26
  28. Ottaviani G27
  29. Sarrafzadegan N28, 29
Show Affiliations
Authors Affiliations
  1. 1. Department of Internal Desiases Propedeutics, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  2. 2. Deputy Director of Research and Preventive Cardiology, National Medical Research Centre of Cardiology named after E. Chazov, Moscow, Russian Federation
  3. 3. Head of Evidence Based Medicine Department, Patrice Lumumba Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation
  4. 4. A. P. Avtsyn Research Institute of Human Morphology, Petrovskiy RNCS, Moscow, Russian Federation
  5. 5. Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Teharan, Iran
  6. 6. Razi Drug Research Centre, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Cardiology, West Virginia University, Morgantown, WV, United States
  8. 8. Institute of Clinical Morphology and Digital Pathology, I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
  9. 9. Atherosclerosis and Metabolic Disorders Research Unit, Alma Mater Studiorum University of Bologna, Bologna, Italy
  10. 10. Chemical Cancerogenesis Department, Institute of Cancerogenesis, National Medical Research Center of Oncology after N. N. Blokhina, Moscow, Russian Federation
  11. 11. Laboratory of Single Cell Biology, Patrice Lumumba Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation
  12. 12. Department of Cardio-Thoracic-Vascular Area, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
  13. 13. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
  14. 14. Head of Pathophysiology Department, Siberian State Medical University, Tomsk, Russian Federation
  15. 15. Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  16. 16. Department of Oncology, Ryazan State Medical University after I. P. Pavlov, Ryazan, Russian Federation
  17. 17. Jawaharlal Nehru Medical College, Belgaum, India
  18. 18. Department of Pathophysiology, Kuban State Medical University, Krasnodar, Russian Federation
  19. 19. Head of Laboratory of Biological Chemistry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
  20. 20. Director of Heart Failure Centre, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  21. 21. Head of Cardio-Oncology Department and Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  22. 22. Hypertension and Cardiovascular Risk Research Unit, Alma Mater Studiorum University of Bologna, Bologna, Italy
  23. 23. IRCCS Policlinico S. Orsola-Malpighi di Bologna, Bologna, Italy
  24. 24. Chief of Coronary Care Unit, Buenos Aires Institute of Cardiology, Buenos Aires, Argentina
  25. 25. Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy
  26. 26. Maria Cecilia Hospital, GVM Care and Research, Cotignola, Italy
  27. 27. Anatomic Pathology, Lino Rossi Research Center, Department of Biomedical, Surgical and Dental Sciences, Universita degli Studi di Milano, Milan, Italy
  28. 28. Director of Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  29. 29. School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, Canada

Source: Cardiovascular Pathology Published:2024


Abstract

Over the years, advancements in the field of oncology have made remarkable strides in enhancing the efficacy of medical care for patients with cancer. These modernizations have resulted in prolonged survival and improved the quality of life for these patients. However, this progress has also been accompanied by escalation in mortality rates associated with anthracycline chemotherapy. Anthracyclines, which are known for their potent antitumor properties, are notorious for their substantial cardiotoxic potential. Remarkably, even after 6 decades of research, a conclusive solution to protect the cardiovascular system against doxorubicin-induced damage has not yet been established. A comprehensive understanding of the pathophysiological processes driving cardiotoxicity combined with targeted research is crucial for developing innovative cardioprotective strategies. This review seeks to explain the mechanisms responsible for structural and functional alterations in doxorubicin-induced cardiomyopathy. © 2024
7. Doxorubicin-Induced Cardiometabolic Disturbances: What Can We Do?, Frontiers in Clinical Diabetes and Healthcare (2025)
Experts (# of related papers)
Other Related Docs
13. Effect of Aloe Vera Against Natural and Chemical Toxicities, Current Nutrition and Food Science (2024)