Doxorubicin-Related Cardiotoxicity: Review of Fundamental Pathways of Cardiovascular System Injury

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Doxorubicin-Related Cardiotoxicity: Review of Fundamental Pathways of Cardiovascular System Injury Publisher Pubmed

Summary: Research shows anthracycline chemo, while effective for cancer, can harm the heart. Understanding its mechanisms is key to safer treatments. #CancerTreatment #HeartHealth

Avagimyan A¹ ; Pogosova N^{2, 3} ; Kakturskiy L⁴ ; Sheibani M^{5, 6} ; Challa A⁷ ; Kogan E⁸ ; Fogacci F⁹ ; Mikhaleva L⁴ ; Vandysheva R⁴ ; Yakubovskaya M^{10, 11} ; Faggiano A^{12, 13} ; Carugo S^{12, 13} ; Urazova O¹⁴ ; Jahanbin B¹⁵ Show All Authors

Avagimyan A¹
Pogosova N^{2, 3}
Kakturskiy L⁴
Sheibani M^{5, 6}
Challa A⁷
Kogan E⁸
Fogacci F⁹
Mikhaleva L⁴
Vandysheva R⁴
Yakubovskaya M^{10, 11}
Faggiano A^{12, 13}
Carugo S^{12, 13}
Urazova O¹⁴
Jahanbin B¹⁵
Lesovaya E^{10, 11, 16}
Polana S¹⁷
Kirsanov K^{10, 11}
Sattar Y⁷
Trofimenko A¹⁸
Demura T⁸
Saghazadeh A¹⁵
Koliakos G¹⁹
Shafie D²⁰
Alizadehasl A²¹
Cicero A^{22, 23}
Costabel JP²⁴
Biondizoccai G^{25, 26}
Ottaviani G²⁷
Sarrafzadegan N^{28, 29}

Source: Cardiovascular Pathology Published:2024

Abstract

Over the years, advancements in the field of oncology have made remarkable strides in enhancing the efficacy of medical care for patients with cancer. These modernizations have resulted in prolonged survival and improved the quality of life for these patients. However, this progress has also been accompanied by escalation in mortality rates associated with anthracycline chemotherapy. Anthracyclines, which are known for their potent antitumor properties, are notorious for their substantial cardiotoxic potential. Remarkably, even after 6 decades of research, a conclusive solution to protect the cardiovascular system against doxorubicin-induced damage has not yet been established. A comprehensive understanding of the pathophysiological processes driving cardiotoxicity combined with targeted research is crucial for developing innovative cardioprotective strategies. This review seeks to explain the mechanisms responsible for structural and functional alterations in doxorubicin-induced cardiomyopathy. © 2024

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Style	Citing Format
MLA	Avagimyan A, et al.. "Doxorubicin-Related Cardiotoxicity: Review of Fundamental Pathways of Cardiovascular System Injury." Cardiovascular Pathology, vol. 73, no. , 2024, pp. -.
APA	Avagimyan A, Pogosova N, Kakturskiy L, Sheibani M, Challa A, Kogan E, Fogacci F, Mikhaleva L, Vandysheva R, Yakubovskaya M, Faggiano A, Carugo S, Urazova O, Jahanbin B, Lesovaya E, Polana S, Kirsanov K, Sattar Y, Trofimenko A, ... Sarrafzadegan N (2024). Doxorubicin-Related Cardiotoxicity: Review of Fundamental Pathways of Cardiovascular System Injury. Cardiovascular Pathology, 73(), -.
Chicago	Avagimyan A, Pogosova N, Kakturskiy L, Sheibani M, Challa A, Kogan E, Fogacci F, et al.. "Doxorubicin-Related Cardiotoxicity: Review of Fundamental Pathways of Cardiovascular System Injury." Cardiovascular Pathology 73, no. (2024): -.
Harvard	Avagimyan A et al. (2024) 'Doxorubicin-Related Cardiotoxicity: Review of Fundamental Pathways of Cardiovascular System Injury', Cardiovascular Pathology, 73(), pp. -.
Vancouver	Avagimyan A, Pogosova N, Kakturskiy L, Sheibani M, Challa A, Kogan E, et al.. Doxorubicin-Related Cardiotoxicity: Review of Fundamental Pathways of Cardiovascular System Injury. Cardiovascular Pathology. 2024;73():-.
BibTex	@article{ author = {Avagimyan A and Pogosova N and Kakturskiy L and Sheibani M and Challa A and Kogan E and Fogacci F and Mikhaleva L and Vandysheva R and Yakubovskaya M and Faggiano A and Carugo S and Urazova O and Jahanbin B and Lesovaya E and Polana S and Kirsanov K and Sattar Y and Trofimenko A and Demura T and Saghazadeh A and Koliakos G and Shafie D and Alizadehasl A and Cicero A and Costabel JP and Biondizoccai G and Ottaviani G and Sarrafzadegan N}, title = {Doxorubicin-Related Cardiotoxicity: Review of Fundamental Pathways of Cardiovascular System Injury}, journal = {Cardiovascular Pathology}, volume = {73}, number = {}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Avagimyan A AU - Pogosova N AU - Kakturskiy L AU - Sheibani M AU - Challa A AU - Kogan E AU - Fogacci F AU - Mikhaleva L AU - Vandysheva R AU - Yakubovskaya M AU - Faggiano A AU - Carugo S AU - Urazova O AU - Jahanbin B AU - Lesovaya E AU - Polana S AU - Kirsanov K AU - Sattar Y AU - Trofimenko A AU - Demura T AU - Saghazadeh A AU - Koliakos G AU - Shafie D AU - Alizadehasl A AU - Cicero A AU - Costabel JP AU - Biondizoccai G AU - Ottaviani G AU - Sarrafzadegan N TI - Doxorubicin-Related Cardiotoxicity: Review of Fundamental Pathways of Cardiovascular System Injury JO - Cardiovascular Pathology VL - 73 IS - SP - EP - PY - 2024 ER -