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Diabetes Mellitus and Risk of Incident Dementia in Apoe E4 Carriers: An Updated Meta-Analysis Publisher Pubmed



Rashtchian A1 ; Etemadi MH2 ; Asadi E1 ; Binaei S3 ; Abbasi M4 ; Bayani M5 ; Izadi E6 ; Sadatmadani SF7 ; Naziri M8 ; Khoshravesh S9 ; Shirani M1 ; Asadi Anar M1 ; Deravi N1
Authors
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Authors Affiliations
  1. 1. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran
  2. 2. Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  4. 4. Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  7. 7. Medical Doctor, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Student Research Committee, School of Health, Iran University of Medical Science, Tehran, Iran
  9. 9. Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: BMC Neuroscience Published:2024


Abstract

Background and aim: Diabetes raises the risk of dementia, mortality, and cognitive decline in the elderly, potentially because of hereditary variables such as APOE. In this study, we aim to evaluate Diabetes mellitus and the risk of incident dementia in APOE e4 carriers. Method: We thoroughly searched PubMed (Medline), Scopus, and Google Scholar databases for related articles up to September 2023. The titles, abstracts, and full texts of articles were reviewed; data were extracted and analyzed. Result: This meta-analysis included nine cohorts and seven cross-sectional articles with a total of 42,390 population. The study found that APOE e4 carriers with type 2 diabetes (T2D) had a 48% higher risk of developing dementia compared to non-diabetic carriers (Hazard Ratio;1.48, 95%CI1.36–1.60). The frequency of dementia was 3 in 10 people (frequency: 0.3; 95%CI (0.15–0.48). No significant heterogeneity was observed. Egger’s test, which we performed, revealed no indication of publication bias among the included articles (p = 0.2). Conclusion: Overall, diabetes increases the risk of dementia, but further large-scale studies are still required to support the results of current research. © The Author(s) 2024.
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