Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Predictors of Survival Rate in Patients With Pancreatic Cancer: A Multi-Center Analytical Study in Iran Publisher Pubmed



Bahardoust M1, 2 ; Abyazi MA1 ; Emami SA3 ; Ghadimi P4 ; Khodabandeh M5 ; Mahmoudi F6 ; Hosseinzadeh R1 ; Heiat M1 ; Agah S7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Medical Students Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Cancer Reports Published:2022


Abstract

Background: Pancreatic cancer (PC) is among the deadliest cancers of the gastrointestinal tract worldwide and a growing global health concern. Aim: This study was aimed to evaluate the survival rate and prognostic factors of survival in patients with PC. Methods: In this retrospective cohort study, the records of 556 patients with PC registered in the hospital cancer registration system from September 2007 to September 2020 were evaluated. In this regard, demographic data, tumor characteristics, received treatments, and patients' final status were analyzed. Kaplan–Meier and Cox's regression were used for univariate and multivariate analyses, respectively. Results: The 5-year survival rate was found to be 4.3%. The median survival time was 12.4 ± 6.6 months. Univariate analysis showed that age, BMI (kg/m2), blood transfusions, differentiation, tumor stage, tumor size, number of involved lymph nodes, lymph node ratio (LNR), and type of treatment received were significantly associated with patient survival (p <.05). Multivariate Cox regression indicated that the age ≥60 years [Hazard Ratio (HR) = 1.25, 95% confidence interval (CI) = 1.03–1.49], BMI <18 (kg/m2; HR = 1.56, 95% CI = 1.13–2.14), poor differentiation (HR = 2.12, 95% CI = 1.75–2.49), tumor size >2.5 cm (HR = 4.61, 95% CI = 3.30–6.78), metastasis presence (HR = 1.97, 95% CI = 1.49–2.60), more than two involved lymph nodes (HR = 1.52, 95% CI = 1.31–1.77), LNR <0.2 (HR = 0.56, 95% CI = 0.36–0.77), and adjuvant therapy with surgery and chemotherapy (HR = 0.44, 95% CI = 0.28–0.61) are the most important prognostic factors of survival in patients with PC (p <.05). Conclusions: This study showed that the survival rate of patients with pancreatic cancer varies based on the characteristics of the tumor and the type of treatment received. © 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC.
Related Docs
View other Related Docs
1. Survival Rate of Patients Suffering From Gastric Adenocarcinoma of Yazd City, Trauma Monthly (2011)
2. Primary Squamous Cell Carcinoma, a Rare Pathological Report of Pancreatic Cancer, Caspian Journal of Internal Medicine (2021)
3. Microbiome As a Biomarker and Therapeutic Target in Pancreatic Cancer, BMC Microbiology (2024)
4. Survival and Recurrence Time Among Patients With Colon Cancer Reffered to Alzahra Hospital, Isfahan, Iran, During 2001-2010, Journal of Isfahan Medical School (2017)
5. Efficacy of Multi-Detector Computerized Tomography Scan, Endoscopic Ultrasound, and Laparoscopy for Predicting Tumor Resectability in Pancreatic Adenocarcinoma, Indian Journal of Gastroenterology (2013)
6. Effects of Disulfiram on Apoptosis in Panc-1 Human Pancreatic Cancer Cell Line, Research in Pharmaceutical Sciences (2014)
7. Results of Combination Chemotherapy and Radiation Therapy in Non-Metastatic Gastric Cancer in Yazd - Iran, Indian Journal of Cancer (2015)
8. Serum Inflammatory Markers As Prognostic Marker for Nasopharyngeal Carcinoma With Liver Metastasis: A Multi-Center Retrospective Study, European Archives of Oto-Rhino-Laryngology (2024)
Experts (# of related papers)
View all Related Experts
Ali Akhavan (2)
Azadeh Moghaddas (2)
Other Related Docs
9. National Surveillance of Cancer Survival in Iran (Irancansurv): Analysis of Data of 15 Cancer Sites From Nine Population-Based Cancer Registries, International Journal of Cancer (2022)
10. Over-Expression of Low-Density Lipoprotein Receptor-Related Protein-1 Is Associated With Poor Prognosis and Invasion in Pancreatic Ductal Adenocarcinoma, Pancreatology (2019)
11. An Effective Concentration of 5-Aza-Cdr to Induce Cell Death and Apoptosis in Human Pancreatic Cancer Cell Line Through Reactivating Rassf1a and Up-Regulation of Bax Genes, Iranian Journal of Medical Sciences (2018)
12. Prevalence of Stomach Cancer in Isfahan Province, Iran, The Gulf journal of oncology (2018)
13. Effect of Number of Dissected Lymph Nodes on Prognosis of Patients With Stage Ii and Iii Colorectal Cancer, Exploration of Medicine (2023)
14. Survival Rate of Colorectal Cancer in Iran: A Systematic Review and Meta-Analysis, Asian Pacific Journal of Cancer Prevention (2019)
15. Temporal Trends of Incidence of Colorectal Cancer in Isfahan, Iran, 2000-2011, International Journal of Preventive Medicine (2018)
16. The Association Between Skeletal Muscle Mass Index (Smi) and Survival After Gastrectomy: A Systematic Review and Meta-Analysis of Cohort Studies, European Journal of Surgical Oncology (2023)
17. Evaluating the Incidence of Postoperative Pancreatic Fistula After Pancreaticojujenostomy Among the Cases of Whipple Surgery, Journal of Isfahan Medical School (2016)
18. Regional Disparities in Cancer Survival in Iran: Insight From a National Surveillance of Cancer Survival in Iran (Irancansurv), Cancer Epidemiology (2023)
19. Incidence, Prevalence, and Mortality Rate of Gastrointestinal Cancer in Isfahan, Iran: Application of the Miamod Method, Asian Pacific Journal of Cancer Prevention (2016)
20. Development of a Tool for Comprehensive Evaluation of Population-Based Cancer Registries, International Journal of Medical Informatics (2018)
21. The Direct Medical Costs of Colorectal Cancer in Iran; Analyzing the Patient's Level Data From a Cancer Specific Hospital in Isfahan, International Journal of Preventive Medicine (2012)
22. Screening and Identification of Potential Biomarkers for Pancreatic Cancer: An Integrated Bioinformatics Analysis, Pathology Research and Practice (2023)
23. Incidence and Risk Factors of Pancreatic Cancer During 15 Years Follow-Up in the Golestan Cohort Study in Iran, PLoS ONE (2024)
24. Predicting Place of Death of Patients With Advanced Cancer Receiving Home-Based Palliative Care Services in Iran, BMC Palliative Care (2024)
25. Investigation of Clinicopathological Parameters in Emergency Colorectal Cancer Surgery: A Study of 67 Patients, Archives of Medical Science (2017)
26. Outcome Evaluation of Ecf, Dcf, Folfox, and Flot Chemotherapy Regimens As Perioperative Treatment in Elderly Patients With Resectable Gastric Cancer; a Retrospective Comparative Study, Journal of Research in Medical Sciences (2023)
27. Comparing the Patterns of Hypertension and Type 2 Diabetes Mellitus in Patients With Colorectal Cancer, Journal of Isfahan Medical School (2014)
28. The Effects of Risk Factors on One-And Five-Year Survival of Patients With Gastric Cancer in Isfahan in 2016, Middle East Journal of Digestive Diseases (2022)
29. Global, Regional, and National Burden of Colorectal Cancer and Its Risk Factors, 1990–2019: A Systematic Analysis for the Global Burden of Disease Study 2019, The Lancet Gastroenterology and Hepatology (2022)