Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Determination of Frequency of Diabetes and Pre-Diabetes in Patients With Nonalcoholic Fatty Liver Disease and Comparison With a Control Group



Pakzad B1 ; Abbasiveldani N2 ; Akbari M3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2016

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western industrialized countries. The pathogenesis of NAFLD has not been clearly determined, but the most widely supported theory is the mechanism of insulin resistance. Therefore, the aim of this study was to evaluate the frequency of diabetes and pre-diabetes in patients with NAFLD. Methods: The present study was performed on 80 patients and 26 healthy controls matched for age and sex. Patients were diagnosed with NAFLD through ultrasound and were selected. From each participant, a 5 cc sample of blood was obtained and sent to a pathology laboratory for analysis. Quantitative data and qualitative data were analyzed using t-test and chi-square test, respectively. Moreover, multivariate tests, such as regression tests, were used where necessary. Findings: Among the participants, 64 (60.3%) were women and 42 (39.7%) were men. The average age of the subjects in the case group was 48.8 ± 10.8 years and in the control group was 42.3 ± 13.4 years. Of the 106 participants, 44 patients (41.5%) had pre-diabetes and 11 (10.4%) had diabetes; all were in the case group. In the control group, no subjects had pre-diabetes (P-value < 0.001) or diabetes (P-value = 0.046). After removing age as a confounder, the only variables that differed significantly between the two groups and were higher in the case group were hemoglobin A1c (HbA1c), fasting plasma glucose, insulin, cholesterol, aspartate transaminase (AST), alanine transaminase (ALT), two-hour blood glucose. Moreover, with the removal of BMI as a confounder, only hemoglobin A1C, fasting blood glucose, insulin, and ALT showed significant differences between the two groups. Conclusion: This study showed that the prevalence of diabetes in patients with NAFLD was high. Even with the removal of confounding factors, factors associated with diabetes, such as hemoglobin A1c, fasting plasma glucose, and insulin, had significant association with this disease, indicating a strong relationship between the two diseases. © 2016, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. First-Degree Relatives of Patients With Type 2 Diabetes Mellitus and Risk of Non-Alcoholic Fatty Liver Disease, Review of Diabetic Studies (2007)
2. Investigation of Cardiovascular Risk Factors in Diabetic and Nondiabetic Patients With Nonalcoholic Fatty Liver Disease, Journal of Research in Medical Sciences (2024)
3. Diet Macronutrients Composition in Nonalcoholic Fatty Liver Disease: A Review on the Related Documents, Hepatitis Monthly (2014)
4. The Effects of Metformin Administration on Liver Enzymes and Body Composition in Non-Diabetic Patients With Non-Alcoholic Fatty Liver Disease And/Or Non-Alcoholic Steatohepatitis: An Up-To Date Systematic Review and Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2020)
5. The Association of Healthy Lifestyle Score and Risk of Non-Alcoholic Fatty Liver Disease, BMC Public Health (2023)
6. Intake of Nutrients, Fiber, and Sugar in Patients With Nonalcoholic Fatty Liver Disease in Comparison to Healthy Individuals, International Journal of Preventive Medicine (2016)
7. Adherence to Low Carbohydrate Diets and Non-Alcoholic Fatty Liver Disease: A Case Control Study, BMC Nutrition (2022)
8. Dietary Advanced Glycation End Products Are Associated With an Increased Risk of Non-Alcoholic Fatty Liver Disease in Iranian Adults, BMC Endocrine Disorders (2023)
Experts (# of related papers)
View all Related Experts
Gholamreza Askari (19)
Awat Feizi (14)
Other Related Docs
9. The Association Between the Dietary Inflammatory Index (Dii) and Some Serum Oxidative Stress Markers in Non-Alcoholic Fatty Liver Disease: Case-Control, International Journal of Preventive Medicine (2022)
10. Salsalate Efficacy on Treatment of Fatty Liver in Diabetes; Clinical Trial in Diabetic and Prediabetic Patients, Journal of Isfahan Medical School (2011)
11. Association Between Dietary Glycemic Index and Non-Alcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus, Frontiers in Endocrinology (2023)
12. Pre-Diabetes and Cardiovascular Risk Factors in Nafld Patients: A Retrospective Comparative Analysis, Frontiers in Endocrinology (2025)
13. Effect of a Moderately Carbohydrate-Restricted Diet on Liver Enzymes, Steatosis and Fibrosis in Normal-Weight Individuals With Non-Alcoholic Fatty Liver Disease: Study Protocol for a Parallel Randomised Controlled Clinical Trial, BMJ Open (2023)
14. Carbohydrate Quality Index and Risk of Non-Alcoholic Fatty Liver Disease in Iranian Adults, BMC Endocrine Disorders (2024)
15. The Association Between Major Dietary Patterns With the Risk of Non-Alcoholic Fatty Liver Disease, Oxidative Stress and Metabolic Parameters: A Case–Control Study, Journal of Diabetes and Metabolic Disorders (2022)
16. Prevalence of Diabetic Neuropathy in Nonalcoholic Fatty Liver Disease (Nafld) Patients: A Systematic Review and Meta-Analysis, Neurology Asia (2024)
17. Prediction of Coronary Atherosclerotic Disease With Liver Transaminase Level, Liver International (2007)
18. The Effect of Green Tea Extract Supplementation on Liver Enzymes in Patients With Nonalcoholic Fatty Liver Disease, International Journal of Preventive Medicine (2015)
19. Non-Alcoholic Steatohepatitis in a Sample of Iranian Adult Population: Age Is a Risk Factor, International Journal of Preventive Medicine (2011)
20. The Effects of Zinc Supplementation on Metabolic Profile and Oxidative Stress in Overweight/Obese Patients With Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Trial, Journal of Trace Elements in Medicine and Biology (2020)
21. Obesity and Air Pollution: Global Risk Factors for Pediatric Non-Alcoholic Fatty Liver Disease, Hepatitis Monthly (2011)
22. Ultrasound Findings of Liver and Pancreas in Children With Type 1 Diabetes Mellitus: A Case-Control Study, Iranian Journal of Radiology (2024)
23. Association Between Lifelines Diet Score With Odds of Nonalcoholic Fatty Liver Disease and Some Novel Anthropometric Indices Among Adults: A Case–Control Study, Frontiers in Nutrition (2024)
24. Predictive Factors of Steatosis and Non-Alcoholic Steatohepatitis in Morbidly Obese Patients Undergoing Bariatric Surgery, Hepatitis Monthly (2017)
25. Effect of Lifestyle Modification Education Based on Health Belief Model in Overweight/Obese Patients With Non-Alcoholic Fatty Liver Disease: A Parallel Randomized Controlled Clinical Trial, Clinical Nutrition ESPEN (2020)
26. Impact of Bariatric Surgery on Liver Fibrosis Indices Among Type 2 Diabetes Patients in a National Cohort, Scientific Reports (2025)
27. The Relationship Between Dietary Antioxidant Intake and Physical Activity Rate With Nonalcoholic Fatty Liver Disease (Nafld): A Case – Control Study, Clinical Nutrition ESPEN (2019)
28. Doppler Perfusion Index in Adolescents With Nonalcoholic Fatty Liver Disease, Immunopathologia Persa (2021)
29. Changes in Liver Enzymes and Metabolic Profile in Adolescents With Fatty Liver Following Exercise Interventions, Pediatric Gastroenterology, Hepatology and Nutrition (2020)
30. The Effects of Low Carbohydrate Diets on Liver Function Tests in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Clinical Trials, Journal of Research in Medical Sciences (2016)
31. Vitamin E + Ursodeoxycholic Acid (Udca) Versus Vitamin E for the Treatment of Non-Alcoholic Steatohepatitis (Nash), Journal of Isfahan Medical School (2010)
32. Adaptation of Clinical Practice Guideline for Assessment of Liver Fibrosis in Patients With Non Alcoholic Fatty Liver Disease in Isfahan Province, International Journal of Preventive Medicine (2024)
33. Improving Data Adequacy of Ultrasonography Reports for Non-Alcoholic Fatty Liver Disease (Nafld) Through a National Structured Template, Acta Radiologica (2023)
34. Dietary Patterns and Risk of Non-Alcoholic Fatty Liver Disease, BMC Gastroenterology (2021)
35. Prognostic Role of Neutrophil to Lymphocyte Ratio in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis, Canadian Journal of Gastroenterology and Hepatology (2022)
36. The Effect of Vitamin D Supplementation on Insulin Resistance in Patients With Nonalcoholic Fatty Liver, Journal of Isfahan Medical School (2015)
37. Risk Score Model for Predicting Sonographic Non-Alcoholic Fatty Liver Disease in Children and Adolescents, Iranian Journal of Pediatrics (2011)
38. The Effect of Synbiotic Supplementation on Body Composition and Lipid Profile in Patients With Nafld: A Randomized, Double Blind, Placebo-Controlled Clinical Trial Study, Iranian Red Crescent Medical Journal (2017)
39. Hepatic Artery and Portal Vein Doppler Indexes in Non-Alcoholic Fatty Liver Disease Before and After Treatment to Prevent Unnecessary Health Care Costs, International Journal of Preventive Medicine (2014)
40. Dietary Phytochemical Index and the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study Among Iranian Adults, Complementary Therapies in Medicine (2022)
41. The Effect of a Mediterranean Diet on Metabolic Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Systematic Review of Randomized Controlled Trials, Clinical Nutrition ESPEN (2020)
42. Metabolic Syndrome and Nonalcoholic Fatty Liver Disease: Nutritional Approach for Prevention, Journal of Isfahan Medical School (2013)
43. The Association of Dietary Phytochemical Index and Nonalcoholic Fatty Liver Disease, Food Science and Nutrition (2023)
44. Dietary Quality Indices and Biochemical Parameters Among Patients With Non Alcoholic Fatty Liver Disease (Nafld), Hepatitis Monthly (2013)
45. The Association of the Healthy Food Diversity Index With the Risk of Non-Alcoholic Fatty Liver Disease Among the Adult Population, Clinical Nutrition ESPEN (2024)
46. Insulin-Like Growth Factor Binding Protein 3 Promoter Variant (Rs2854744) Is Associated With Nonalcoholic Fatty Liver Disease, Archives of Endocrinology and Metabolism (2023)
47. Sesame Oil Ameliorates Alanine Aminotransferase, Aspartate Aminotransferase, and Fatty Liver Grade in Women With Nonalcoholic Fatty Liver Disease Undergoing Low-Calorie Diet: A Randomized Double-Blind Controlled Trial, International journal of clinical practice (2022)
48. Association Between Type 2 Diabetes and Different Types of Dietary Fats: A Case-Control Study, Clinical Nutrition ESPEN (2023)
49. Effects of the Mixture of Melissa Officinalis L., Cinnamomum Zeylanicutn and Urtica Dioica on Hepatic Enzymes Activity in Patients With Nonalcoholic Fatty Liver Disease, International Journal of Pharmacology (2012)
50. Serum Uric Acid Level and Its Association With Cardiometabolic Risk Factors in Prediabetic Subjects, Journal of Research in Medical Sciences (2014)