Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Norepinephrine, Neurodevelopment and Behavior Publisher Pubmed



Saboory E1 ; Ghasemi M2 ; Mehranfard N3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
  2. 2. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Neurophysiology Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran

Source: Neurochemistry International Published:2020


Abstract

Neurotransmitters play critical roles in the developing nervous system. Among the neurotransmitters, norepinephrine (NE) is in particular postulated to be an important regulator of brain development. NE is expressed during early stages of development and is known to regulate both the development of noradrenergic neurons and the development of target areas. NE participates in the shaping and the wiring of the nervous system during the critical periods of development, and perturbations in this process can alter the brain's developmental trajectory, which in turn can cause long-lasting and even permanent changes in the brain function and behavior later in life. Here we will briefly review evidence for the role of noradrenergic system in neurodevelopmental processes and will discuss about the potential disruptors of noradrenergic system during development and their behavioral consequences. © 2020 Elsevier Ltd
Related Docs
1. Negative Relationship Between Brain Α1a-Ar Neurotransmission and Βarr2 Levels in Anxious Adolescent Rats Subjected to Early Life Stress, Experimental Brain Research (2020)
2. Mechanisms Underlying Anticonvulsant and Proconvulsant Actions of Norepinephrine, Neuropharmacology (2018)
3. Anxiety and Hippocampal Neuronal Activity: Relationship and Potential Mechanisms, Cognitive, Affective and Behavioral Neuroscience (2022)
4. The Dose-Dependent Neuroprotective Effect of Norepinephrine in Improving Memory Retrieval in an Experimental Model of Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis, Brain Research Bulletin (2024)
5. Neuroprotective Actions of Norepinephrine in Neurological Diseases, Pflugers Archiv European Journal of Physiology (2024)
6. Long-Term Decreases in the Expression of Calcineurin and Gabaa Receptors Induced by Early Maternal Separation Are Associated With Increased Anxiety-Like Behavior in Adult Male Rats, Developmental Neuroscience (2021)
7. Environmental Factors Influencing the Risk of Autism, Journal of Research in Medical Sciences (2017)
Experts (# of related papers)
Maedeh Ghasemi (5)