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Insulin-Related Liver Pathways and the Therapeutic Effects of Aerobic Training, Green Coffee, and Chlorogenic Acid Supplementation in Prediabetic Mice Publisher Pubmed



Abdollahi M1 ; Marandi SM1 ; Ghaedi K2 ; Safaeinejad Z3 ; Kazeminasab F4 ; Shirkhani S1 ; Sanei MH5 ; Rezvanian P3 ; Nasresfahani MH3
Authors
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Authors Affiliations
  1. 1. Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Iran
  2. 2. Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology University of Isfahan, Iran
  3. 3. Department of Animal Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Iran
  4. 4. Department of Physical Education and Sport Sciences, Faculty of Human Sciences, University of Kashan, Kashan, Iran
  5. 5. Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Oxidative Medicine and Cellular Longevity Published:2022


Abstract

Background. The liver controls blood glucose levels via regulation of anabolic (glycogen synthesis and gluconeogenesis) and catabolic (glycolysis and glycogenolysis) processes through activation of the PI3K-AKT signalling pathway. The aim of this study was to assess the effect of aerobic training, green coffee, and chlorogenic acid supplementation on glucose metabolism-regulating pathways in prediabetic mice. Methods. C57BL/6 mice were exposed to a high-fat diet and physical activity limitation to induce a state of prediabetes. After 12 weeks, mice were fed a high-fat diet compared to the control mice. The prediabetic mice were further treated with either green coffee, chlorogenic acid, or training or combinations of the same for 10 weeks. At the end of the experimental period, metabolic data (FBG, GTT, HOMA for IR, plasma level of insulinfrom systematic, AST, and ALT assessed into blood), histopathologic, and analysis of gene and protein expressions were obtained for target tissues. Results. Training along with green coffee and chlorogenic acid supplementation improved complications of prediabetes including weight gain and elevated fasting blood glucose and plasma insulin levels. These effects were associated with the changes in mRNA levels of genes important in hepatic glycogen synthesis (GYS2), glucogenesis (PCK and G6PC2), and glycolysis (GK, PK, and PFKL). Conclusion. The training in conjunction with green coffee or chlorogenic acid is effective in the prevention of prediabetes in mice. As these interventions are relatively inexpensive and safe application to individuals with prediabetes appears warranted. © 2022 Milad Abdollahi et al.
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