Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Preventive Effect of Pumpkin (Cucurbita Pepo L.) on Diabetic Index and Histopathology of Pancreas in Alloxan-Induced Diabetes in Rats



Kazemi S1 ; Asgari S2 ; Moshtaghian SJ3 ; Rafieian M4 ; Mahzooni P5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biology, School of Sciences, University of Isfahan, Isfahan, Iran
  2. 2. Isfahan Cardiovascular Research Center, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Biology, School of Science, University of Isfahan, Isfahan, Iran
  4. 4. Herb Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
  5. 5. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2011

Abstract

Introduction: Nowadays, medicinal plants are novel therapeutic approaches in the treatment of diabetes. This study aimed at assessing preventive effect of different doses of Cucurbita pepo (Pumpkin) on blood glucose and insulin levels and pancreas tissue in rats with diabetes. Methods: In this experience male white Wistar rats were randomly divided into four groups of seven each: 1, normal group, 2, diabetic group, 3. preventive + low dose of pumpkin powder (1 g/kg) and 4. preventive + pumpkin powder (2g/kg). Groups 3 and 4 received pumpkin powder with gavage injection for 6 weeks, daily and were injected with alloxan (120 mg/kg) at the end of the second week. Fasting blood samples were collected before of injection of alloxan and at the end of experimental period. Pancreas tissue samples in all groups were collected to be microscopic investigated. Finding: There was no significant difference between the groups in level of fasting blood sugar and insulin before alloxan injection. The results indicated a significant decrease in fasting blood sugar and significant increase in insulin level in the treated groups with pumpkin powder compared to diabetic group. There was not any significant difference between function of the high and low dosages of pumpkin powder (P < 0.05). Histological studies of the pancreas tissue samples confirmed that on the base, the consumed pumpkin had significant effects on increasing the size of pancreatic islets. Conclusion: Based on these results, it is suggested that pumpkin powder consume has favorable effects in preventing hyperglycemia and the histopathological changes of pancreas in diabetes.
Related Docs
View other Related Docs
1. Hypoglycaemic and Hypolipidemic Effects of Pumpkin (Cucurbita Pepo L.) on Alloxan-Induced Diabetic Rats, African Journal of Pharmacy and Pharmacology (2011)
2. Effects of Cornus Mas L. on Blood Glucose, Insulin and Histopathology of Pancreas in Alloxan-Induced Diabetic Rats, Journal of Isfahan Medical School (2011)
3. Protective and Therapeutic Effects of Phoenix Dactylifera Leaf Extract on Pancreatic Β-Cells and Diabetic Parameters in Streptozotocin-Induced Diabetic Rats, Comparative Clinical Pathology (2020)
4. Effect of Hydroalcoholic and Buthanolic Extract of Cucumis Sativus Seeds on Blood Glucose Level of Normal and Streptozotocin-Induced Diabetic Rats, Iranian Journal of Basic Medical Sciences (2011)
5. Biochemical and Histopathological Study of the Anti-Hyperglycemic and Anti-Hyperlipidemic Effects of Cornelian Cherry (Cornus Mas L.) in Alloxan-Induced Diabetic Rats, Journal of Complementary and Integrative Medicine (2014)
6. Effects of Cucurbita Ficifolia Intake on Type 2 Diabetes: Review of Current Evidences, Shiraz E Medical Journal (2014)
7. Effect of Cucurbita Ficifolia and Probiotic Yogurt Consumption on Blood Glucose, Lipid Profile, and Inflammatory Marker in Type 2 Diabetes, International Journal of Preventive Medicine (2016)
8. Anti-Diabetic Effects of Walnut Oil on Alloxan-Induced Diabetic Rats, African Journal of Pharmacy and Pharmacology (2011)
Experts (# of related papers)
View all Related Experts
Nepton Soltani (16)
Sedigheh Asgary (15)
Other Related Docs
9. Effect of Ethanolic Extract of Juglans Regia L. on Blood Sugar in Diabetes-Induced Rats, Journal of Medicinal Food (2008)
10. The Effects of Aqueous Extract of Alfalfa on Blood Glucose and Lipids in Alloxan-Induced Diabetic Rats, Interventional Medicine and Applied Science (2015)
11. Comparative Study of Anti-Diabetic Effects of Insulin, Epigenin and Salvia Mirzayanii Extract in Streptozotocin-Induced Diabetic Male Rats, Indian Journal of Biochemistry and Biophysics (2023)
12. Antidiabetic Effect of Hydroalcoholic Extract of Carthamus Tinctorius L. in Alloxan-Induced Diabetic Rats, Journal of Research in Medical Sciences (2012)
13. The Protective Effects of Ziziphus Vulgaris L. Fruits on Biochemical and Histological Abnormalities Induced by Diabetes in Rats, Journal of Complementary and Integrative Medicine (2014)
14. Antioxidant Plants and Diabetes Mellitus, Journal of Research in Medical Sciences (2015)
15. The Effect of Cucurbita Consumption on Non-Communicable Diseases, Cucurbita: Biology, Distribution and Habitat (2020)
16. Antihyperglycemic and Antihyperlipidemic Effect of Chronic Administration of Hesperetin in Diabetic Rats, Journal of Babol University of Medical Sciences (2010)
17. Effects of Berberis Vulgaris Fruit Extract on Oxidative Stress Status in the Kidney and Liver of Diabetic Rats, Journal of Complementary and Integrative Medicine (2024)
18. Effects of Hydroalcoholic Extract of Juglans Regia Leaves on Activity of Ast and Alt Enzymes in Alloxan- Induced Diabetic Rats, Pharmaceutical Sciences (2009)
19. Evaluation of the Effects of Cornus Mas L. Fruit Extract on Glycemic Control and Insulin Level in Type 2 Diabetic Adult Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Evidence-based Complementary and Alternative Medicine (2015)
20. The Effects of Methanolic, Chloroform, and Ethylacetate Extracts of the Cucurbita Pepo L. on the Delay Type Hypersensitivity and Antibody Production, Research in Pharmaceutical Sciences (2012)
21. Biochemical and Histopathological Changes in Kidney of Diabetic Rats Treated With Hydroalcoholic Extract of Centaurea Cyanus, Journal of Mazandaran University of Medical Sciences (2016)
22. The Effects of Ethanol Extract of Berberis Vulgaris Fruit on Histopathological Changes and Biochemical Markers of the Liver Damage in Diabetic Rats, Iranian Journal of Basic Medical Sciences (2017)
23. Effects of Salvia Mirzayanii Extract Administration on Hyperglycemia Improvement in Diabetic Rats: The Role of Glut4, Pepck and G6pase Genes, Heliyon (2024)
24. Renal Biochemical and Histopathological Alterations of Diabetic Rats Under Treatment With Hydro Alcoholic Morus Nigra Extract, Journal of Renal Injury Prevention (2017)
25. Effects of Methanolic and Butanolic Fractions of Allium Elburzense Wendelbo Bulbs on Blood Glucose Level of Normal and Stz-Induced Diabetic Rats, Research in Pharmaceutical Sciences (2012)
26. Effect of Hordeum Vulgare L. (Barley) on Blood Glucose Levels of Normal and Stz-Induced Diabetic Rats, Research in Pharmaceutical Sciences (2014)
27. Phytotherapy in Burn Wound Healing: A Review of Native Iranian Medicinal Plants, Journal of Chemical Health Risks (2023)
28. The Histological Changes in Endocrine Part of the Pancreas of Diabetic Rats Treated With Rosa Damascena Extract, Journal of Isfahan Medical School (2020)
29. The Effect of Pumpkin and Probiotic Yogurt Consumption Separately Or/And Simultaneously on Type Ii Diabetes, Journal of Isfahan Medical School (2014)
30. The Effect of Rosa Damascena Extract on Blood Glucose and Insulin Levels in Diabetic Rats, Journal of Isfahan Medical School (2020)
31. Effects of Fenugreek Seeds on Adipogenesis and Lipolysis in Normal and Diabetic Rats, Pakistan Journal of Biological Sciences (2014)
32. Effect of Vanadyl Sulfate on Fructose-Induced Insulin Resistance Rat, Iranian Biomedical Journal (2003)
33. Effect of Magnesium Sulfate Administration to Improve Insulin Resistance in Type 2 Diabetes Animal Model: Using the Hyperinsulinemic-Euglycemic Clamp Technique, Fundamental and Clinical Pharmacology (2018)
34. Effect of Oral Magnesium Sulfate Administration on Blood Glucose Hemostasis Via Inhibition of Gluconeogenesis and Foxo1 Gene Expression in Liver and Muscle in Diabetic Rats, Biomedicine and Pharmacotherapy (2019)
35. Cardiovascular Effects of Cydonia Oblonga Miller (Quince), Evidence-based Complementary and Alternative Medicine (2022)
36. The Effect of Curcumin on Anthropometric Indices, Blood Pressure, Lipid Profiles, Fasting Blood Glucose, Liver Enzymes, Fibrosis, and Steatosis in Non-Alcoholic Fatty Livers, Frontiers in Nutrition (2023)
37. Gamma-Aminobutyric Acid Attenuates Insulin Resistance in Type 2 Diabetic Patients and Reduces the Risk of Insulin Resistance in Their Offspring, Koomesh (2023)
38. The Effect of Phytochemicals in Prediabetic Patients: A Systematic Review of Randomized Controlled Trials, Phytotherapy Research (2023)
39. Magnesium Sulfate Improves Insulin Resistance in High Fat Diet Induced Diabetic Parents and Their Offspring, European Journal of Pharmacology (2021)
40. Does Fenugreek (Trigonella Foenum-Graecum) Seed Improve Inflammation, and Oxidative Stress in Patients With Type 2 Diabetes Mellitus? a Parallel Group Randomized Clinical Trial, European Journal of Integrative Medicine (2018)
41. Salsalate Efficacy in Blood Glucose Level Reduction in Diabetes, Journal of Isfahan Medical School (2009)
42. Effect of the Hydroalcoholic Extract and Juice of Prunus Divaricata Fruit on Blood Glucose and Serum Lipids of Normal and Streptozotocin Induced Diabetic Rats, Research in Pharmaceutical Sciences (2014)
43. Gamma-Aminobutyric Acid Attenuates Insulin Resistance in Type 2 Diabetic Patients and Reduces the Risk of Insulin Resistance in Their Offspring, Biomedicine and Pharmacotherapy (2021)
44. Applying the Taguchi Design for Optimized Formulation of Sustained Release Gliclazide Chitosan Beads: An in Vitro/In Vivo Study, AAPS PharmSciTech (2009)
45. Low Doses of Vanadyl Sulfate Protect Rats From Lipid Peroxidation and Hypertriglyceridemic Effects of Fructose-Enriched Diet, International Journal of Diabetes and Metabolism (2006)
46. Alterations in Lipid Peroxidation, Lipid Profile, Insulin Sensitivity, and Hepatic Histopathological Changes in Diabetic Rats Following the Treatment With Salvadora Persica, Journal of Cellular Biochemistry (2019)
47. Effects of Pistacia Atlantica on Oxidative Stress Markers and Antioxidant Enzymes Expression in Diabetic Rats, Journal of the American College of Nutrition (2019)
48. Antioxidant Effect of Ziziphus Vulgaris, Portulaca Oleracea, Berberisintegerima and Gundelia Tournefortti on Lipid Peroxidation, Hb Glycosylation and Red Blood Cell Hemolysis, Journal of Medicinal Plants (2011)
49. Preventive Effect of Three Pomegranate (Punica Granatum L.) Seeds Fractions on Cerulein-Induced Acute Pancreatitis in Mice, International Journal of Preventive Medicine (2014)
50. Curcumin-Piperine Co-Supplementation and Human Health: A Comprehensive Review of Preclinical and Clinical Studies, Phytotherapy Research (2023)