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Regulatory Effects of Chronic Low-Dose Morphine on Nitric Oxide Level Along With Baroreflex Sensitivity in Two-Kidney One-Clip Hypertensive Rats Pubmed



Rezazadeh H1 ; Kahnouei MH1 ; Hassanshahi G2 ; Allahtavakoli M1 ; Shamsizadeh A1 ; Roohbakhsh A1 ; Fatemi I1 ; Zarisfi M1 ; Pourshanazari AA1, 3
Authors
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Authors Affiliations
  1. 1. Physiology-Pharmacology Research Center, Rafsanjan University of Medical Science, Rafsanjan, Iran
  2. 2. Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  3. 3. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Journal of Kidney Diseases Published:2014


Abstract

Introduction. Opiates are traditionally used for treatment of some acute heart disorders. There are only few reports on the effects of long-term treatment of cardiovascular diseases with morphine. This study aimed to investigate the effects of chronic low-dose morphine use on the cardiovascular system in two-kidney one-clip (2K1C) hypertensive rats. Materials and Methods. Male Wistar rats were divided into two groups as the sham and 2K1C groups and each group was further subdivided into saline and morphine treatment subgroups. Blood pressure, heart rate, plasma rennin activity, serum nitric oxide concentration, and baroreflex sensitivity were measured. Results. Morphine significantly attenuated systolic blood pressure, diastolic blood pressure, and mean arterial pressure in the 2K1C animals. In addition, morphine decreased plasma rennin activity in the 2K1C group. Serum concentrations of nitric oxide were also decreased, and morphine prevented the reduction of nitric oxide. The baroreflex sensitivity was also improved following morphine administration in the 2K1C group. Conclusions. According to the results presented in this study, chronic administration of low-dose morphine reduces regulated hypertension in the 2K1C rats, probably via a nitric oxide-dependent pathway.
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