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Coronary Angiogenesis During Morphine and Nicotine Withdrawal in Two-Kidney One Clip Hypertensive (2K1c) Rats Publisher Pubmed



Zeinivand M1 ; Pourshanazari AA2 ; Hassanshahi G3
Authors
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Authors Affiliations
  1. 1. Physiology-Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Molecular Medicine Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Source: Bratislava Medical Journal Published:2015


Abstract

OBJECTIVE: This study was aimed to investigate the effects of addiction to nicotine and morphine and their withdrawal on coronary angiogenesis and serum NO concentrations in two-kidney one-clip hypertensive (2K1C) rats. METHODS: Male hypertensive rats were divided into the two below groups: Group (1): Rats received saline for 8 weeks (n = 8); Group (2): Rats received morphine and nicotine for 8 weeks (n = 32). At the end of 8 weeks, the groups (2) were divided into the four sub-groups, which three of them were treated with withdrawal drugs. Following treatments, blood pressure, heart rate, plasma renin activity (PRA), NO concentration and capillary density were measured. RESULTS: Results showed that blood pressure was signifi cantly reduced in the addicted group when compared to non-addicted (p <0.05). The withdrawal completely reversed blood pressure to the level observed pre-addiction (p <0.05). Coronary angiogenesis was signifi cantly lower in the addicted group in comparistion to normal (p <0.05) but withdrawal of addiction did not improve angiogenesis. CONCLUSION: On the basis of the present fi ndings, it may be indicative that the risk of cardiovascular complications in addiction is concurrent to chronic hypertension, which shows the importance of early diagnosis and treatment in clinical condition (Fig. 4, Ref. 59). Text in PDF www.elis.sk.
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