The Effects of Aloe Vera‑Peppermint (Veramint) Moisturizing Gel on Oral Mucositis Caused by Chemotherapy Among Cancer Patients Hospitalized in Intensive Care Units: A Triple‑Blind Randomized Placebo‑Controlled Trial Publisher



MM ; Atashi V ; Bekhradi R ; Ghafari S
Source: Shiraz E Medical Journal Published:2025

Abstract

Background: Chemotherapy medications, which are used to treat many malignant tumors, can cause a variety of side effects, including oral mucositis. Objectives: The present study aimed to examine the effects of oral Veramint gel on the treatment of chemotherapy-induced oral mucositis. Methods: The present triple-blind clinical trial was conducted in two groups and three stages. The study included 70 patients with cancer (35 in each group) and chemotherapy-induced oral mucositis. Samples were selected via simple random sampling. The rate and severity of oral mucositis were measured by the researcher using the Oral Mucositis Assessment Scale (OMAS) for both intervention and control groups before the intervention, and then 7 and 14 days after the intervention. Data were analyzed using SPSS software. We used the CONSORT reporting guidelines. Results: The intervention group showed a significant reduction in oral mucositis scores, from 26.5 ± 3.56 to 0.14 ± 0.21 after 14 days. In contrast, the control group showed minimal change, from 23.88 ± 4.31 to 22.22 ± 3.99. Statistical analysis revealed significant differences between the two groups at 7 and 14 days post-intervention, with P-values of 0.001 at both time points, confirming the effectiveness of the aloe vera and peppermint essential oils gel in reducing oral mucositis. Conclusions: According to the results of this study, Veramint gel, which contains aloe vera and peppermint essential oils, can improve chemotherapy-induced oral mucositis. Therefore, once further studies confirm its effectiveness, it can be recommended for patients with mucositis as it has no side effects and is cost-effective. © 2025 Elsevier B.V., All rights reserved.