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Ascorbate Reduces Morphine-Induced Extracellular Dopac Level in the Nucleus Accumbens: A Microdialysis Study in Rats Publisher Pubmed



Rajaei Z1 ; Alaei H1 ; Nasimi A1 ; Amini H2 ; Ahmadiani A2
Authors
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Authors Affiliations
  1. 1. Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Neuroscience Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

Source: Brain Research Published:2005


Abstract

Most drugs of abuse increase dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) release in the shell of the nucleus accumbens. The effects of ascorbate, which is known to modulate dopamine neurotransmission, on the extracellular level of DOPAC in the nucleus accumbens of naive rats and of rats treated acutely with morphine were studied by using in vivo microdialysis and high performance liquid chromatography with electrochemical detection (HPLC-ECD). Acute morphine (20 mg/kg ip) treatment increased the level of DOPAC in the nucleus accumbens to approximately 170% of basal level. Acute treatment with ascorbate (500 mg/kg ip) alone did not alter nucleus accumbens' DOPAC level, but pretreatment with ascorbate (500 mg/kg ip) 30 min before morphine administration attenuated the effects of acute morphine on the level of DOPAC. These results suggest that ascorbate modulates the mesolimbic dopaminergic pathway. © 2005 Elsevier B.V. All rights reserved.
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