Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Aerobic Exercise on Dopamine Release in Periaqueductal Gray Region Following the Use of Morphine in Rat Publisher



Alizadeh S1 ; Kargarfard M1 ; Alaei H2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Exercise Physiology, School of Sports Sciences, University of Isfahan, Isfahan, Iran
  2. 2. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2018


Abstract

Background: Several studies have shown that exercise plays an important role in modifying addictive behaviors. Moreover, it seems that morphine exerts its effects on periaqueductal gray (PAG) region, which contains dopamine neurons, through the release of dopamine in this area. Therefore, in this study, we decided to evaluate the effect of aerobic exercise on the release of dopamine in the periaqueductal gray region following the use of morphine in rat. Methods: 28 male Wistar rats were selected and randomly divided into 4 groups of saline, morphine, saline + exercise, and morphine + exercise. Exercise groups ran on the treadmill apparatus during four weeks. Three doses of morphine (10, 20, and 40 mg/kg) were injected intraperitoneally in 9 days, and withdrawal symptoms were recorded. After preparing different specimens in 50 μl samples, the concentration of dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) were measured using high-performance liquid chromatography (HPLC). To compare the mean levels of dopamine and DOPAC, one-way ANOVA and Tukey's post hoc tests were used. Findings: The concentrations of dopamine and DOPAC were significantly higher in morphine, morphine + exercise, and saline + exercise compared to saline group (P < 0.050 for all). Conclusion: The results of this study show that aerobic exercise may have an important role in releasing dopamine and DOPAC into the periaqueductal gray region area, and it can be used for prevention and treatment of morphine addiction. © 2018, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. The Blockade of D1 /D2-Like Dopamine Receptors in the Lateral Periaqueductal Gray Region Affects Morphine Self-Administration With and Without Exercise in Rats, Physiology and Pharmacology (Iran) (2021)
2. Effect of Treadmill Running on Morphine Dependence Before and After Medial Prefrontal Cortex Lesion in Rats, Asian Journal of Sports Medicine (2016)
3. The Effect of Aerobic Exercise on Tendency to Consumption of Morphine in Male Rat, Journal of Isfahan Medical School (2016)
4. Blockade of Prelimbic Glutamate Receptor Reduces the Reinforcing Effect of Morphine, Canadian Journal of Physiology and Pharmacology (2018)
5. Ascorbic Acid Decreases Morphine Self-Administration and Withdrawal Symptoms in Rats, Pathophysiology (2005)
6. Treadmill Exercise Reduces Self-Administration of Morphine in Male Rats, Pathophysiology (2009)
7. The Effects of Mid-Term Running Activity on Passive Avoidance Learning and Memory in Opioid Addicted Rats, Journal of Isfahan Medical School (2009)
8. Effects of Microinjection of Angiotensin Ii and Captopril Into Nucleus Accumbens on Morphine Self-Administration in Rats, Indian Journal of Experimental Biology (2009)
Experts (# of related papers)
View all Related Experts
Hojatallah Alaei (57)
Parham Reisi (14)
Other Related Docs
9. Effect of Physical Activity on Symptoms of Morphine Addiction in Rats, After and Before of Lesion of the Mpfc Area, Iranian Journal of Basic Medical Sciences (2013)
10. Different Current Intensities Electrical Stimulation of Prelimbic Cortex of Mpfc Produces Different Effects on Morphine-Induced Conditioned Place Preference in Rats, Behavioural Brain Research (2012)
11. Lesion of Medial Prefrontal Cortex Reduces Morphine-Induced Extracellular Dopamine Level in the Ventral Tegmental Area: A Microdialysis Study in Rats, Pharmacology Biochemistry and Behavior (2012)
12. Preventive Effects of Fixed and Progressive Forced Exercises on Memory and Brain Electrical Activity in Morphine-Addicted Rats, Anais da Academia Brasileira de Ciencias (2022)
13. The Effect of the Blockage of the Receptors of Glutamate N-Methyl-D-Aspartate (Nmda) in Prefrontal Cortex on Morphine Tendency in Male Rat, Journal of Isfahan Medical School (2016)
14. Effects of Microinjection of Angiotensin Ii and Captopril to Vta on Morphine Self-Administration in Rats, Acta Biologica Hungarica (2009)
15. The Effect of Short-Term Physical Activity (Treadmill Running) on Spatial Learning and Memory in the Intact and Morphine Dependent Male Rats, Journal of Isfahan Medical School (2008)
16. Forced Exercise Improves Passive Avoidance Memory in Morphine-Exposed Rats, Pakistan Journal of Biological Sciences (2009)
17. Ascorbate Reduces Morphine-Induced Extracellular Dopac Level in the Nucleus Accumbens: A Microdialysis Study in Rats, Brain Research (2005)
18. Evaluation of Medical Prefrontal Cortex (Mpfc) Stimulation and Destruction Effects on Addiction to Morphine, Journal of Isfahan Medical School (2013)
19. The Effect of Short-Term Physical Activity on Withdrawal Symptoms With or Without Mpfc Area in Male Rats Influenced by Morphine, Journal of Isfahan Medical School (2013)
20. Effects of Treadmill Exercise and Chronic Stress on Anxiety-Like Behavior, Neuronal Activity, and Oxidative Stress in Basolateral Amygdala in Morphine-Treated Rats, Synapse (2023)
21. The Role of Gabab Receptors in Morphine Self-Administration, International Journal of Preventive Medicine (2013)
22. Angiotensin Converting Enzyme Inhibitor Captopril Modifies Conditioned Place Preference Induced by Morphine and Morphine Withdrawal Signs in Rats, Pathophysiology (2007)
23. The Effects of Angiotensin Ii and Captopril on Expression of Morphine Withdrawal Signs in Rat, Iranian Journal of Pharmaceutical Research (2007)
24. Effects of Electrical Stimulation and Temporary Inactivation of Basolateral Amygdala on Morphine-Induced Conditioned Place Preference in Rats, Neuroscience Letters (2022)
25. Roles of the Nucleus Accumbens (Shell) in the Acquisition and Expression of Morphine-Induced Conditioned Behavior in Freely Moving Rats, International Journal of Preventive Medicine (2014)
26. Effect of Morphine Self-Administration on Water and Food Intake in Rat, Iranian Journal of Basic Medical Sciences (2007)
27. The Blockade of Glutamate N-Methyl-D-Aspartate Receptors Into the Prelimbic of Prefrontal Cortex Decreases Morphine-Induced Conditioned Place Preference in Rat, Indonesian Biomedical Journal (2017)
28. Treadmill Running Reverses Retention Deficit Induced by Morphine, European Journal of Pharmacology (2006)
29. Electrical Stimulation Mpfc Affects Morphine Addiction by Changing Glutamate Concentration in the Ventral Tegmental Area, Metabolic Brain Disease (2019)
30. Effect of Electrical Stimulation of Central Nucleus of the Amygdala on Morphine Conditioned Place Preference in Male Rats, Iranian Journal of Basic Medical Sciences (2022)
31. Tramadol Versus Methadone for the Management of Acute Opioid Withdrawal: An Add-On Study, Journal of Research in Medical Sciences (2006)
32. Acute and Chronic Effects of Nitrendipine on Naloxone Precipitated Morphine Withdrawal in Mice, Iranian Journal of Pharmaceutical Research (2004)
33. Involvement of Ampa Receptors of Lateral Habenula in the Expression and Acquisition Phases of Morphine-Induced Place Preference, Brain Research (2023)
34. Effect of Intracerebroventricular Injection of Gaba Receptors Antagonists on Morphine-Induced Changes in Gaba and Glu Transmission Within the Mpfc: An in Vivo Microdialysis Study, Iranian Journal of Basic Medical Sciences (2019)
35. Neuroprotective Effects of Endurance Training in 6-Hydroxydopamine Rat Model of Parkinson’S Disease, Koomesh (2020)
36. The Effect of Perphenazine Add-On Therapy to Matrix Intervention on Control of Craving and Relapse in Methamphetamine Users: A Randomized Controlled Trial, International Journal of High Risk Behaviors and Addiction (2022)
37. An Assessment Between D1 Receptor Agonist and D2 Receptor Antagonist Into the Ventral Tegmental Area on Conditioned Place Preference and Locomotor Activity, Advanced Biomedical Research (2019)
38. Different Responses of Nitric Oxide Synthase Inhibition on Morphine-Induced Antinociception in Male and Female Rats, Pathophysiology (2011)
39. Identification of Morphine Accumulation in the Rat Embryo Central Nervous System: A C14-Morphine Administration Study, International Journal of Preventive Medicine (2013)
40. The Effect of Intrathecal Administration of the Neuronal N-Type Calcium Channels Antagonist, Ω-Conotoxin Mviia, on Attenuating the Spontaneous and Naloxone-Precipitated Morphine Withdrawal in Rats, Toxin Reviews (2016)
41. Non-Invasive Temporal Interference Brain Stimulation Reduces Preference on Morphine-Induced Conditioned Place Preference in Rats, Scientific Reports (2024)
42. Neuronal Calcium Channels Blocker, Ziconotide (ɷ-Conotoxin Mviia), Reverses Morphine Withdrawal-Induced Memory Impairments Via Alteration in Hippocampal Nmda Receptor Expression in Rats, Toxin Reviews (2020)
43. Involvement of Basolateral Amygdala Dopamine D1 Receptors in the Acquisition and Expression of Morphine-Induced Place Preference in Rats, Advanced Biomedical Research (2022)
44. The Acute Effects of Different Doses of Tramadol on Neuronal Activity of Medial Prefrontal Cortex in Rats, Advanced Biomedical Research (2022)
45. Effects of the Persian Carum Copticum Fruit Extracts on Morphine Withdrawal Syndrome in Mice, Research in Pharmaceutical Sciences (2012)
46. Simvastatin Prevents Morphine-Induced Tolerance and Dependence in Mice, Biomedicine and Pharmacotherapy (2017)
47. Pretreatment With Crocin Along With Treadmill Exercise Ameliorates Motor and Memory Deficits in Hemiparkinsonian Rats by Anti-Inflammatory and Antioxidant Mechanisms, Metabolic Brain Disease (2019)
48. Antinociceptive Effect of Clavulanic Acid and Its Preventive Activity Against Development of Morphine Tolerance and Dependence in Animal Models, Research in Pharmaceutical Sciences (2014)
49. The Effect of Add-On Buprenorphine to Matrix Program in Reduction of Craving and Relapse Among People With Methamphetamine Use Disorder: A Randomized Controlled Trial, Journal of Clinical Psychopharmacology (2021)
50. The Electrical Stimulation of the Central Nucleus of the Amygdala in Combination With Dopamine Receptor Antagonist Reduces the Acquisition Phase of Morphine-Induced Conditioned Place Preference in Male Rat, Research in Pharmaceutical Sciences (2023)