Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Noncommunicable Disease, Clinical Course and Covid-19 Prognosis: Results Based on I-Core Registry; [Maladies Non Transmissibles, Evolution Clinique Et Pronostic De Covid-19: Resultats Bases Sur Le Registre I-Core] Publisher Pubmed



Javanmard S1 ; Mohammadifard N2 ; Nasirian M3 ; Vaseghi G5 ; Heidari K6 ; Kelidari B7 ; Changiz T8 ; Sarrafzadegan N5, 9
Authors
Show Affiliations
Authors Affiliations
  1. 1. Applied Physiology Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Infectious Diseases and Tropical Medicine Research Center
  4. 4. and Department of Epidemiology and Biostatistics, Health School, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Social Determinants of Health Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Surgery, Isfahan Minimally Invasive Surgery and Obesity Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Medical Education, Medical Educational Research Center, Isfahan University of Medical Science, Isfahan, Iran
  9. 9. School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, Canada

Source: Eastern Mediterranean Health Journal Published:2021


Abstract

Background: There are no data on the association between clinical course and comorbidity in Iranian patients with COVID-19. Aims: To determine noncommunicable disease (NCD), clinical characteristics and prognosis of patients hospitalized with COVID-19 in Isfahan, Islamic Republic of Iran. Methods: This multicentric retrospective observational study was performed on all patients hospitalized with COVID-19 in Isfahan from 17 February to 6 April 2020. We recruited 5055 patients. Data on clinical course and comorbid NCDs such as hypertension, coronary heart disease (CHD), diabetes mellitus (DM), cancer, chronic kidney disease (CKD) and chronic respiratory disease (CRD) were collected. Statistical analyses were done by Mann–Whitney U, χ2 and logistic regression tests using Stata version 14. Results: DM and hypertension were the most prevalent comorbidities in patients with positive and negative reverse transcription polymerase chain reaction (RT-PCR). Odds ratio (95% confidence interval) of mortality-associated factors was significant for DM [1.35 (1.07–1.70)], CHD [1.58 (1.26–1.96)], CRD [2.18 (1.58–3.0)], and cancer [3.55 (2.42–5.21)]. These results remained significant for cancer after adjustment for age, sex and clinical factors. Among patients with positive RT-PCR, death was significantly associated with CRD and cancer, while this association disappeared after adjustment for all potential confounders. There was a significant association between NCDs and higher occurrence of low oxygen saturation, mechanical ventilation requirement and intensive care unit admission after adjustment for age and sex. Conclusion: The presence of NCDs alone did not increase mortality in patients with COVID-19, after adjustment for all potential confounders including clinical factors. © World Health Organization (WHO) 2021.
Related Docs
View other Related Docs
1. Sex Differences in the Relation Between Comorbidities and Prognosis in Hospitalized Patients With Covid-19, Interdisciplinary Perspectives on Infectious Diseases (2022)
2. Risk Factors, Clinical, and Laboratory Characteristics of Patients With a Diagnosis of Covid-19, Journal of Emergency Practice and Trauma (2022)
3. Multivariable Analysis of Clinical and Laboratory Data Manifestations Predicting Severity and Mortality Risk in Patients With Coronavirus Disease 2019 in the Mountainous West of Iran: A Retrospective Single-Center Study, Asian Biomedicine (2022)
4. The Outcomes of Covid-19 Epidemic Crisis on the Elderly: A Review Study, Journal of Isfahan Medical School (2021)
5. Is Chronic Kidney Disease, a Predictor of In-Hospital Mortality in Coronavirus Disease 2019 (Covid-19) Patients?, Advanced Biomedical Research (2023)
6. The Covid-19 Pandemic: Knowledge, Attitudes and Practices of Coronavirus (Covid-19) Among Patients With Type 2 Diabetes, Journal of Health, Population and Nutrition (2023)
7. Evaluation of Epidemiologic, Clinical and Laboratory Findings of Covid-19 Patients in Intensive Care Units, Alzahra Hospital; [بررسی یافته‌های اپیدمیولوژیک، بالینی و آزمایشگاهی بیماران مبتلا به کووید-19 بستری در بخش‌های مراقبت ویژه بیمارستان الزهرا (س)], Journal of Isfahan Medical School (2024)
8. D-Dimer Levels in Predicting Severity of Infection and Outcome in Patients With Covid-19, Tanaffos (2022)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (25)
Marjan Mansourian (18)
Other Related Docs
9. Diagnostic and Prognostic Value of Sepsis-Induced Coagulopathy and International Society on Thrombosis and Hemostasis Scoring Systems in Covid-19-Associated Disseminated Intravascular Coagulopathy, Journal of Research in Medical Sciences (2021)
10. Severity of Disease and Covid-19 Complications During Hospital Stay: A Prospective Cohort Study, Archives of Iranian Medicine (2022)
11. Factors Associated With Mortality in Hospitalized Cardiovascular Disease Patients Infected With Covid-19, Immunity, Inflammation and Disease (2022)
12. Intravenous Methylprednisolone Pulse As a Treatment for Hospitalised Severe Covid-19 Patients: Results From a Randomised Controlled Clinical Trial, European Respiratory Journal (2020)
13. Isfahan Covid Cohort Study: Rationale, Methodology, and Initial Results, Journal of Research in Medical Sciences (2022)
14. Meta-Analysis of Cardiovascular Events and Related Biomarkers Comparing Survivors Versus Non-Survivors in Patients With Covid-19, American Journal of Cardiology (2020)
15. The Clinical Manifestation and Outcome of Covid-19 in Patients With a History of Ischemic Heart Disease; a Retrospective Case-Control Study, BMC Cardiovascular Disorders (2023)
16. Covid-19, an Early Investigation From Exposure to Treatment Outcomes in Tehran, Iran, Journal of Research in Medical Sciences (2021)
17. Chronic Kidney Disease and Covid-19 Infection: A Case–Control Study, Advanced Biomedical Research (2022)
18. Corona Virus Disease 2019 (Covid-19) and Its Effect on Renal System, a Systematic Review and Meta-Analysis, Iranian Journal of Kidney Diseases (2020)
19. Epidemiological Review of the Coronavirus Disease 2019 (Covid-19) Pandemic up to 15 March 2020, Journal of Isfahan Medical School (2020)
20. Association of the Medication Protocols and Longitudinal Change of Covid-19 Symptoms: A Hospital-Based Mixed-Statistical Methods Study, Journal of Biopharmaceutical Statistics (2024)
21. The Negative Impact of Obesity on the Occurrence and Prognosis of the 2019 Novel Coronavirus (Covid-19) Disease: A Systematic Review and Meta-Analysis, Eating and Weight Disorders (2022)
22. The Demographic, Clinical, and Medical Manifestations of Pulmonary Thromboembolism Development in Covid-19, Blood Research (2021)
23. Mesenchymal Stem Cells: A Potent Cell Source for Covid-19, Coronaviruses (2021)
24. A One-Year Hospital-Based Prospective Covid- 19 Open-Cohort in the Eastern Mediterranean Region: The Khorshid Covid Cohort (Kcc) Study, PLoS ONE (2020)
25. Predictive Performance of Qsofa in Confirmed Covid-19 Patients Presenting to the Emergency Department, Tzu Chi Medical Journal (2023)
26. Laboratory Findings of Covid-19 Infection Are Conflicting in Different Age Groups and Pregnant Women: A Literature Review, Archives of Medical Research (2020)
27. N-Acetylcysteine and Coronavirus Disease 2019: May It Work As a Beneficial Preventive and Adjuvant Therapy? a Comprehensive Review Study, Journal of Research in Medical Sciences (2020)
28. Automatic Classification Between Covid-19 and Non-Covid-19 Pneumonia Using Symptoms, Comorbidities, and Laboratory Findings: The Khorshid Covid Cohort Study, Frontiers in Medicine (2021)
29. Chest Computed Tomography Severity Score to Predict Adverse Outcomes of Patients With Covid-19, Infection and Chemotherapy (2021)
30. A Mini-Review on Cardiovascular and Hematological Complications of Covid-19, Coronaviruses (2021)
31. The Covid-19 Pandemic: A Systematic Review of the Current Evidence; [Пандемия Covid-19: Систематический Обзор Современных Данных], Russian Journal of Infection and Immunity (2020)
32. Lactate Dehydrogenase to Albumin Ratio As a Predictive Factor of Covid-19 Patients’ Outcome; a Cross-Sectional Study, Archives of Academic Emergency Medicine (2022)
33. Age-Dependent Clinical Features and Prognosis of Covid-19 Patients, Tanaffos (2021)
34. Factors Related to Preventive Covid-19 Behaviors Using Health Belief Model Among General Population: A Cross-Sectional Study in Iran, BMC Public Health (2021)
35. Emerging Coronaviruses: First Sars, Second Mers and Third Sars-Cov-2. Epidemiological Updates of Covid-19, Infezioni in Medicina (2020)
36. Cardiovascular Risk Factors and Clinical Outcomes Among Patients Hospitalized With Covid-19: Findings From the World Heart Federation Covid-19 Study, Global Heart (2022)
37. Baseline Socioeconomic Status Predicting Post-Covid-19 Symptoms: Results From Isfahan Covid Cohort (Icc) Study, Preventive Medicine Reports (2024)
38. Covid-19 Management in the Emergency Ward, Journal of Research in Medical Sciences (2021)
39. The Potential Effect of Royal Jelly on Biomarkers Related to Covid-19 Infection and Severe Progression, Advances in Experimental Medicine and Biology (2023)
40. Risk Factors for In-Hospital Mortality Among Patients With Coronavirus-19 in Isfahan City, Iran, Advanced Biomedical Research (2022)
41. Electrolyte Abnormalities in Hospitalized Covid-19 Patients at Tertiary Referral Centers in Tehran: Hypermagnesemia As a Marker of Fatality: A Retrospective Cross-Sectional Study, Health Science Reports (2023)
42. Covid-19 and Substance Use Disorders: Recommendations to a Comprehensive Healthcare Response. an International Society of Addiction Medicine Practice and Policy Interest Group Position Paper, Basic and Clinical Neuroscience (2020)
43. A Narrative Review of Covid-19: The New Pandemic Disease, Iranian Journal of Medical Sciences (2020)
44. Current Status of Covid-19 Pandemic; Characteristics, Diagnosis, Prevention, and Treatment, Journal of Research in Medical Sciences (2020)
45. Evaluation of the Effectiveness of the Modified Nutrition Risk in the Critically Ill (Mnutric) Score in Critically Ill Patients Affected by Covid-19 Admitted to the Intensive Care Unit (Icu), BMC Nutrition (2022)
46. Cardiac Involvement According to Echocardiographic Findings in Severe Coronavirus Disease 2019, ARYA Atherosclerosis (2021)
47. Epidemiology, Virology, Clinical Features, Diagnosis, and Treatment of Sars-Cov-2 Infection, Journal of Experimental and Clinical Medicine (Turkey) (2021)
48. Gastrointestinal and Kidney Manifestations in Sarscov and Sars-Cov-2 Infections: Role of Angiotensin-Converting Enzyme 2, Physiology and Pharmacology (Iran) (2021)
49. T-Cell Immunophenotyping in Covid-19 Pneumonia, Journal of Research in Medical Sciences (2021)
50. Risk Factors Associated With Intensive Care Unit (Icu) Admission and In-Hospital Death Among Adults Hospitalized With Covid-19: A Two-Center Retrospective Observational Study in Tertiary Care Hospitals, Emergency Radiology (2021)