Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Severity of Disease and Covid-19 Complications During Hospital Stay: A Prospective Cohort Study Publisher Pubmed



Sami R1 ; Soltaninejad F1 ; Shayganfar A2 ; Mirfendereski S2 ; Mansourian M3 ; Khademi N4 ; Dehghan M4 ; Khorrami Z5 ; Jalali S6 ; Mokhtari Z7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Biostatistics, Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Ophthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Archives of Iranian Medicine Published:2022


Abstract

Background: COVID-19, with its high transmission and mortality rates and unknown outcomes, has become a major concern in the world. Among people with COVID-19, severe cases can quickly progress to serious complications, and even death. So, the present study aimed to examine the relationship between the severity of the disease and the outcome in patients afflicted by COVID-19 during hospitalization. Methods: A total of 653 patients with COVID-19 aged 18 years or older were included from Khorshid hospital in Isfahan, Iran and followed for a mean of 22.72 days (median 23.50; range 1–47). Severe COVID-19 was defined by respiration rate≥30 times/min, oxygen saturation level≤88% in the resting position, and pulse rate≥130/min. The primary outcome was mortality. The secondary outcomes included need for mechanical ventilation and intensive care unit (ICU) admission. Results: During 4233 person-days of follow-up, 49 (7.5%) deaths, 27 (4.1%) invasive ventilation and 89 (13.6%) ICU admissions in hospital were reported. After adjustment for potential confounders, severity of the disease was positively associated with risk of mortality, invasive ventilation and ICU admissions (hazard ratio [HR]: 5.99; 95% CI: 2.85, 12.59; P<0.001, HR: 7.09; 95% CI: 3.24, 15.52; P<0.001 and HR: 4.88; 95% CI: 2.98, 7.98; P<0.001, respectively). In addition, greater age (HR=1.04; 95% CI=1.02-1.07; P=0.002), chronic kidney disease (HR=3.05; 95% CI=1.35, 6.90; P=0.008), blood urea nitrogen (BUN) (HR=1.04; 95% CI=1.03–1.05; P<0.001) and creatinine (HR=1.44; 95% CI=1.26-1.65; P<0.001) were probably significant risk factors for mortality in severe COVID-19 patients. Conclusion: More intensive therapy and special monitoring should be implemented for patients with older age, hypertension and kidney disease who are infected with COVID-19 to prevent rapid worsening. 2022 The Author(s).
Related Docs
View other Related Docs
1. Multivariable Analysis of Clinical and Laboratory Data Manifestations Predicting Severity and Mortality Risk in Patients With Coronavirus Disease 2019 in the Mountainous West of Iran: A Retrospective Single-Center Study, Asian Biomedicine (2022)
2. Association of Systemic Complications With Mortality in Coronavirus Disease of 2019: A Cohort Study on Intensive Care Unit Patients, Journal of Research in Medical Sciences (2022)
3. Age-Dependent Clinical Features and Prognosis of Covid-19 Patients, Tanaffos (2021)
4. Risk Factors Associated With Intensive Care Unit (Icu) Admission and In-Hospital Death Among Adults Hospitalized With Covid-19: A Two-Center Retrospective Observational Study in Tertiary Care Hospitals, Emergency Radiology (2021)
5. Clinical, Laboratory, and Chest Ct Features of Dead Versus Recovered Coronavirus Disease 2019 (Covid-19) Patients: A Multicenter Study, Journal of Health Sciences and Surveillance System (2023)
6. Bacterial Superinfection and Antibiotic Management in Patients With Covid-19 Admitted to Intensive Care Medicine in Central Iran: A Follow-Up Study, Advanced Biomedical Research (2023)
7. Evaluation of the Outcome of Covid-19 Disease in Patients Under Mechanical Ventilation Hospitalized in Al-Zahra Hospital, Isfahan in 2019; [بیمارستان الزهرا اصفهان در سال 1299ررسی پیامد بیماري کووید- 19 در بیماران تحت تهویه مکانیکی بستري در], Tehran University Medical Journal (2022)
8. Factors Related to the Hospital Admissions of Covid-19 Patients in the Intensive Care Unit of Selected Iranian Navy Hospitals, Iranian Journal of War and Public Health (2021)
Experts (# of related papers)
View all Related Experts
Ramin Sami (27)
Shaghayegh Haghjooy Javanmard (17)
Other Related Docs
9. Intravenous Methylprednisolone Pulse As a Treatment for Hospitalised Severe Covid-19 Patients: Results From a Randomised Controlled Clinical Trial, European Respiratory Journal (2020)
10. Risk Factors for In-Hospital Mortality Among Patients With Coronavirus-19 in Isfahan City, Iran, Advanced Biomedical Research (2022)
11. Is Non-Invasive Ventilation a Good Choice in All Patients With Severe Covid-19? a Cohort Retrospective Study, Tanaffos (2024)
12. Evaluation of Epidemiologic, Clinical and Laboratory Findings of Covid-19 Patients in Intensive Care Units, Alzahra Hospital; [بررسی یافته‌های اپیدمیولوژیک، بالینی و آزمایشگاهی بیماران مبتلا به کووید-19 بستری در بخش‌های مراقبت ویژه بیمارستان الزهرا (س)], Journal of Isfahan Medical School (2024)
13. Hemoperfusion in Patients With Severe Covid-19 Respiratory Failure, Lifesaving or Not?, Journal of Research in Medical Sciences (2021)
14. Diagnostic and Prognostic Value of Sepsis-Induced Coagulopathy and International Society on Thrombosis and Hemostasis Scoring Systems in Covid-19-Associated Disseminated Intravascular Coagulopathy, Journal of Research in Medical Sciences (2021)
15. Gastrointestinal and Renal Complications in Sars-Cov-2-Infected Patients: Role of Immune System, Scandinavian Journal of Immunology (2021)
16. Nervous System Involvement in Covid-19: A Review of the Current Knowledge, Molecular Neurobiology (2021)
17. A One-Year Hospital-Based Prospective Covid- 19 Open-Cohort in the Eastern Mediterranean Region: The Khorshid Covid Cohort (Kcc) Study, PLoS ONE (2020)
18. Post-Discharge Health Assessment in Survivors of Coronavirus Disease: A Time-Point Analysis of a Prospective Cohort Study, Quality of Life Research (2023)
19. Chest Computed Tomography Severity Score to Predict Adverse Outcomes of Patients With Covid-19, Infection and Chemotherapy (2021)
20. Covid-19, an Early Investigation From Exposure to Treatment Outcomes in Tehran, Iran, Journal of Research in Medical Sciences (2021)
21. Lactate Dehydrogenase to Albumin Ratio As a Predictive Factor of Covid-19 Patients’ Outcome; a Cross-Sectional Study, Archives of Academic Emergency Medicine (2022)
22. Rehabilitation, a Necessity in Hospitalized and Discharged People Infected With Covid-19: A Narrative Review, Physical Therapy Reviews (2021)
23. A Review of Pathophysiological Mechanism, Diagnosis, and Treatment of Thrombosis Risk Associated With Covid-19 Infection, IJC Heart and Vasculature (2022)
24. Is Chronic Kidney Disease, a Predictor of In-Hospital Mortality in Coronavirus Disease 2019 (Covid-19) Patients?, Advanced Biomedical Research (2023)
25. Predicting Covid-19 Hospital Stays With Kolmogorov–Gabor Polynomials: Charting the Future of Care, Information (Switzerland) (2023)
26. Clinical Display, Diagnostics and Genetic Implication of Novel Coronavirus (Covid-19) Epidemic, European Review for Medical and Pharmacological Sciences (2020)
27. A Mini-Review on Cardiovascular and Hematological Complications of Covid-19, Coronaviruses (2021)
28. Isfahan Covid Cohort Study: Rationale, Methodology, and Initial Results, Journal of Research in Medical Sciences (2022)
29. Aspects of Epidemiology, Pathology, Virology, Immunology, Transmission, Prevention, Prognosis, Diagnosis, and Treatment of Covid.19 Pandemic: A Narrative Review, International Journal of Preventive Medicine (2021)
30. Risk Factors, Clinical, and Laboratory Characteristics of Patients With a Diagnosis of Covid-19, Journal of Emergency Practice and Trauma (2022)
31. Skin Manifestations As Potential Symptoms of Diffuse Vascular Injury in Critical Covid-19 Patients, Journal of Cutaneous Pathology (2021)
32. Evaluation of the Effectiveness of the Modified Nutrition Risk in the Critically Ill (Mnutric) Score in Critically Ill Patients Affected by Covid-19 Admitted to the Intensive Care Unit (Icu), BMC Nutrition (2022)
33. Clinical Symptoms of Covid-19 and Their Association With Disease Outcome, Advanced Biomedical Research (2022)
34. Cancer Care Management During the Covid-19 Pandemic, Risk Management and Healthcare Policy (2020)
35. Model Prediction for In-Hospital Mortality in Patients With Covid-19: A Case–Control Study in Isfahan, Iran, American Journal of Tropical Medicine and Hygiene (2021)
36. Clinical Characteristics of Covid-19-Infected Cancer Patients, Isfahan, Iran, Journal of Research in Medical Sciences (2022)
37. On Admission Hemoglobin and Albumin, As the Two Novel Factors Associated With Thrombosis in Covid-19 Pneumonia, Journal of Renal Injury Prevention (2022)
38. N-Acetylcysteine and Coronavirus Disease 2019: May It Work As a Beneficial Preventive and Adjuvant Therapy? a Comprehensive Review Study, Journal of Research in Medical Sciences (2020)
39. Association Between Clinical Characteristics and Laboratory Findings With Outcome of Hospitalized Covid-19 Patients: A Report From Northeast Iran, Interdisciplinary Perspectives on Infectious Diseases (2021)
40. Prevention of Covid-19: Preventive Strategies for General Population, Healthcare Setting, and Various Professions, Advances in Experimental Medicine and Biology (2021)
41. The Value of Thoracic Computed Tomography Scan Comparing to Reverse Transcription-Polymerase Chain Reaction for the Diagnosis of Covid-19, Journal of Research in Medical Sciences (2021)
42. Sars-Cov-2 (Covid-19): New Discoveries and Current Challenges, Applied Sciences (Switzerland) (2020)
43. The Covid-19 Pandemic: A Systematic Review of the Current Evidence; [Пандемия Covid-19: Систематический Обзор Современных Данных], Russian Journal of Infection and Immunity (2020)
44. Pulmonary Function, Anxiety, Depression, and Sleep Quality After Recovery From Covid-19, Tanaffos (2023)
45. Electrolyte Abnormalities in Hospitalized Covid-19 Patients at Tertiary Referral Centers in Tehran: Hypermagnesemia As a Marker of Fatality: A Retrospective Cross-Sectional Study, Health Science Reports (2023)
46. Differential Diagnostic Utility of Clinical Laboratory Data in Patients With Severe and Non-Severe Covid-19, Shiraz E Medical Journal (2022)
47. The Outcomes of Covid-19 Epidemic Crisis on the Elderly: A Review Study, Journal of Isfahan Medical School (2021)
48. Corona Virus Disease 2019 (Covid-19) and Its Effect on Renal System, a Systematic Review and Meta-Analysis, Iranian Journal of Kidney Diseases (2020)
49. A Narrative Review of Covid-19: The New Pandemic Disease, Iranian Journal of Medical Sciences (2020)
50. Noncommunicable Disease, Clinical Course and Covid-19 Prognosis: Results Based on I-Core Registry; [Maladies Non Transmissibles, Evolution Clinique Et Pronostic De Covid-19: Resultats Bases Sur Le Registre I-Core], Eastern Mediterranean Health Journal (2021)