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High-Salt Intake During Pregnancy May Influence the Outcome of Renal Ischemia/Reperfusion in in Adult Offspring Publisher



Shahzamani F1, 2 ; Monajemi R2 ; Nematbakhsh M1, 3, 4
Authors
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Authors Affiliations
  1. 1. Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
  3. 3. Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. IsfahanMN Institute of Basic and Applied Sciences Research, Isfahan, Iran

Source: Journal of Renal Injury Prevention Published:2018


Abstract

Introduction: The salt diet during the pregnancy may disturb the adult offspring's organs functions. Objectives: This study was designed to determine the role of high salt intake during pregnancy on the outcome of renal ischemia reperfusion (IR) in adult offspring. Materials and Methods: Renal IR was induced in 55 adult male and female offspring from mothers who intake high salt or normal drinking water during pregnancy, and the kidney function was evaluated. Results: Salt intake during pregnancy increased the serum levels of creatinine (Cr) and blood urea nitrogen (BUN) and decreased creatinine clearances (ClCr) level in offspring after renal IR gender dependently. Conclusion: The structural change in kidney of offspring from mothers who were subjected to salt intake during pregnancy may influence the outcomes of offspring's kidney functions after renal IR. © 2018 The Author(s).
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