Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Basolateral Amygdala Nucleus Lesion on Memory Under Acute, Mid and Chronic Stress in Male Rats Publisher Pubmed



Ranjbar H1 ; Radahmadi M1 ; Alaei H1 ; Reisi P1 ; Karimi S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Turkish Journal of Medical Sciences Published:2016


Abstract

Background/aim: The basolateral amygdala (BLA) modulates memory for emotional events and is involved in both stress and memory. This study investigated different durations of stress and the role of BLA on serum corticosterone level and spatial and cognitive memory. Materials and methods: Different durations of stress (acute, mid, and chronic stress), with and without BLA lesion were induced in rats by 6 h/day restraint stress for 1, 7, and 21 days. Memory functions were evaluated by novel object recognition (NOR) and object location test (OLT). Results: The OLT findings showed locomotor activity and spatial memory slightly decreased with different durations of stress. The NOR findings significantly showed locomotor activity impairment in different durations of stress. Cognitive memory deficit was observed in mid stress. The corticosterone level significantly increased in the mid and chronic stress groups. Moreover, the mid stress was the strongest stress condition. There is a possibility that different stress durations act by different mechanisms. The recognition of a novel location decreased in all lesion groups. It was more severe in the NOR. The BLA lesion significantly decreased corticosterone level in the mid and chronic stress groups compared to similar groups without lesion. Conclusion: The BLA lesion caused more damage to cognitive than spatial memory in stressed groups. © TUBITAK.
Related Docs
View other Related Docs
1. Effect of Different Durations of Stress on Spatial and Cognitive Memory in Male Rats, Journal of Isfahan Medical School (2015)
2. Effects of Crocin on Cognitive and Spatial Memories in Rats Under Chronic Isolation Stress, Physiology and Pharmacology (Iran) (2018)
3. Effects of Crocin on Locomotor Activity As Well As Novel Object Recognition and Object Location Memories in Chronic Restraint Stressed Rats, Physiology and Pharmacology (Iran) (2020)
4. Effects of Electrical Lesion of Basolateral Amygdala Nucleus on Rat Anxiety-Like Behaviour Under Acute, Sub-Chronic, and Chronic Stresses, Clinical and Experimental Pharmacology and Physiology (2017)
5. Effects of Stress on Serum and Hippocampal Il-1Β and Glucose Levels As Well As Retention in Rats, Indian Journal of Physiology and Pharmacology (2017)
6. Therapeutic Effects of Saffron Extract on Different Memory Types, Anxiety, and Hippocampal Bdnf and Tnf-Α Gene Expressions in Sub-Chronically Stressed Rats, Nutritional Neuroscience (2022)
7. The Effect of Preventive, Therapeutic and Protective Exercises on Hippocampal Memory Mediators in Stressed Rats, Malaysian Journal of Medical Sciences (2016)
8. The Protective Effects of Escitalopram on Chronic Restraint Stress-Induced Memory Deficits in Adult Rats, Physiology and Pharmacology (Iran) (2022)
Experts (# of related papers)
View all Related Experts
Maryam Radahmadi (39)
Hojatallah Alaei (22)
Other Related Docs
9. Increase in Brain Corticosterone Concentration and Recognition Memory Impairment Following Morphine Withdrawal in Mice, Stress (2009)
10. The Effects of Subchronic Social and Isolation Stresses on Learning and Memory Trend in Male Rats, Physiology and Pharmacology (Iran) (2018)
11. Effects of Different Timing of Stress on Corticosterone, Bdnf and Memory in Male Rats, Physiology and Behavior (2015)
12. Comparing the Effects of Crocin at Different Doses on Excitability and Long-Term Potentiation in the Ca1 Area, As Well As the Electroencephalogram Responses of Rats Under Chronic Stress, Metabolic Brain Disease (2021)
13. Effects of Prolonged Escitalopram Administration on Long-Term Potentiation Within the Hippocampal Ca1 Area in Rats Under Predictable and Unpredictable Chronic Mild Stress, Metabolic Brain Disease (2024)
14. Stress Biomarker Responses to Different Protocols of Forced Exercise in Chronically Stressed Rats, Journal of Bodywork and Movement Therapies (2017)
15. Metyrapone and Mifepristone Reverse Recognition Memory Loss Induced by Spontaneous Morphine Withdrawal in Mice, Basic and Clinical Pharmacology and Toxicology (2008)
16. The Effects of Acute, Sub-Chronic and Chronic Psychical Stress on the Brain Electrical Activity in Male Rats, Physiology and Pharmacology (Iran) (2017)
17. Effects of Different Dark Chocolate Diets on Memory Functions and Brain Corticosterone Levels in Rats Under Chronic Stress, Physiology and Pharmacology (Iran) (2020)
18. Effect of Exercise, Exercise Withdrawal, and Continued Regular Exercise on Excitability and Long-Term Potentiation in the Dentate Gyrus of Hippocampus, Brain Research (2016)
19. Comparative Study of the Protective Effects of Crocin and Exercise on Long-Term Potentiation of Ca1 in Rats Under Chronic Unpredictable Stress, Life Sciences (2020)
20. The Protective Effects of Escitalopram on Synaptic Plasticity in the Ca1 Region of Chronically Stressed and Non-Stressed Male Rats, International Journal of Developmental Neuroscience (2022)
21. Effects of Chronic Empathic Stress on Synaptic Efficacy, As Well As Short-Term and Long-Term Plasticity at the Schaffer Collateral/Commissural– Ca1 Synapses in the Dorsal Hippocampus of Rats, Metabolic Brain Disease (2025)
22. In Vivo Synaptic Potency, Short-Term and Long-Term Plasticity at the Hippocampal Schaffer Collateral-Ca1 Synapses: Role of Different Light–Dark Cycles in Male Rats, Brain Research (2023)
23. The Effects of Nbm- Lesion on Synaptic Plasticity in Rats, Brain Research (2017)
24. The Impact of Different Dark Chocolate Dietary Patterns on Synaptic Potency and Plasticity in the Hippocampal Ca1 Area of the Rats Under Chronic Isolation Stress, Nutritional Neuroscience (2023)
25. The Protective Effects of Crocin on Input-Output Functions and Long-Term Potentiation of Hippocampal Ca1 Area in Rats Exposed to Chronic Social Isolated Stress, Basic and Clinical Neuroscience (2022)
26. Comparing Various Types of Chronic Psychological Stress on Cognitive Functions and Behaviors in Rats, Basic and Clinical Neuroscience (2024)
27. Comparative Study of Crh Microinjections Into Pvn and Cea Nuclei on Food Intake, Ghrelin, Leptin, and Glucose Levels in Acute Stressed Rats, Basic and Clinical Neuroscience (2021)
28. The Role of Cyclooxygenase 2 in the Cognitive Impairment Induced by Alcohol or Stress in Rats, Advanced Biomedical Research (2021)
29. Effect of Repeated Administration of Corticotropin-Releasing Hormone (Crh) in Central Amygdala Nucleus on Feeding Behavior in Adult Male Rats, Journal of Isfahan Medical School (2017)
30. Vitamin C Alleviates Neurobehavioral Deficits, Igf1 Expression, and Neuronal Damage Induced by Chronic Social Isolation Stress in the Hippocampus of Adult Male Rats, Proceedings of the National Academy of Sciences India Section B - Biological Sciences (2024)
31. Effect of Chronic Stress on Short and Long-Term Plasticity in Dentate Gyrus; Study of Recovery and Adaptation, Neuroscience (2014)
32. The Effect of Synchronized Running Activity With Chronic Stress on Passive Avoidance Learning and Body Weight in Rats, International Journal of Preventive Medicine (2013)
33. The Effect of Synchronized Forced Running With Chronic Stress on Short, Mid and Long- Term Memory in Rats, Asian Journal of Sports Medicine (2013)
34. The Effects of Anethum Graveolens Essence on Scopolamine-Induced Memory Impairment in Mice, Research in Pharmaceutical Sciences (2016)
35. The Effects of Cck-8S on Spatial Memory and Long-Term Potentiation at Ca1 During Induction of Stress in Rats, Iranian Journal of Basic Medical Sciences (2017)
36. Effect of Intraparaventricular Administration of Corticotropin Releasing Hormone on Food Intake in Food-Deprived Rats, Journal of Isfahan Medical School (2017)
37. Cortisol Impacted on Explicit Learning Encoding, But Not on Storage and Retrieval, and Was Not Associated With Sleep Patterns-Results From the Trier Social Stress Test for Children (Tsst-C) Among 9-Years Old Children, Frontiers in Psychology (2018)
38. Neuronal Calcium Channels Blocker, Ziconotide (ɷ-Conotoxin Mviia), Reverses Morphine Withdrawal-Induced Memory Impairments Via Alteration in Hippocampal Nmda Receptor Expression in Rats, Toxin Reviews (2020)
39. Saffron (Crocus Sativus L.) Extract Prevents and Improves D-Galactose and Nano 2 Induced Memory Impairment in Mice, EXCLI Journal (2012)
40. Comparing the Therapeutic Effects of Crocin, Escitalopram and Co-Administration of Escitalopram and Crocin on Learning and Memory in Rats With Stress-Induced Depression, Malaysian Journal of Medical Sciences (2021)
41. Comparative Effects of Chronic Administrations of Gabapentin, Pregabalin and Baclofen on Rat Memory Using Object Recognition Test, Research in Pharmaceutical Sciences (2017)
42. The Impacts of Diabetes in Pregnancy on Hippocampal Synaptogenesis in Rat Neonates, Neuroscience (2016)
43. The Effect of Photoperiodic Stress on Anxiety-Like Behaviors, Learning, Memory, Locomotor Activity and Memory Consolidation in Rats, Physiology and Pharmacology (Iran) (2023)
44. Protective Effect of Honey on Learning and Memory Impairment, Depression and Neurodegeneration Induced by Chronic Unpredictable Mild Stress, Physiology and Pharmacology (Iran) (2021)
45. Preventive and Therapeutic Effect of Treadmill Running on Chronic Stress-Induced Memory Deficit in Rats, Journal of Bodywork and Movement Therapies (2015)
46. Therapeutic Effects of Exercise, Escitalopram and Exercise-Accompanied Escitalopram on Brain Functions in Rats With Depression, Physiology and Pharmacology (Iran) (2022)
47. Effects of Chronic Social Equality and Inequality Conditions on Passive Avoidance Memory and Ptsd-Like Behaviors in Rats Under Chronic Empathic Stress, International Journal of Neuroscience (2024)
48. The Impact of Crocin and Chronic Isolation Stress on Passive Avoidance Memory and Brain Electrical Activity in Male Rats, Physiology and Pharmacology (Iran) (2022)
49. Comparing the Efficacy of Escitalopram With and Without Crocin in Restoring I/O Functions and Ltp Within the Hippocampal Ca1 Region of Stressed Rats, Advanced Biomedical Research (2024)
50. The Effect of Nimodipine on Memory Loss Following Naloxone-Induced Morphine Withdrawal in Object Recognition, Research in Pharmaceutical Sciences (2014)