Increase in Brain Corticosterone Concentration and Recognition Memory Impairment Following Morphine Withdrawal in Mice

Isfahan University of Medical Sciences

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Increase in Brain Corticosterone Concentration and Recognition Memory Impairment Following Morphine Withdrawal in Mice Publisher Pubmed

Rabbani M¹ ; Hajhashemi V¹ ; Mesripour A²

Show Affiliations

1. Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2. School of Pharmacy and Pharmaceutical Sciences, Isfahan Pharmaceutical Sciences Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Stress Published:2009

Abstract

Glucocorticoid hormones evidently affect memory. Morphine withdrawal causes a cognitive deficit and an increase in corticosterone secretion. In the present study brain corticosterone concentrations were determined after morphine withdrawal. Male mice were made dependent by increasing doses of morphine over 3 days. Blood and brain samples were collected following withdrawal induced by injection of naloxone (0.1 mg/kg) or spontaneously after 4 and 14 h. Brain corticosterone was extracted and measured by enzyme immunoassay. Short-term memory was determined in the novel object recognition task, using a 20 min interval between the learning trial and the test trial. In this memory trial, the difference in exploration between a previously seen object and a novel object is taken as an index of memory performance (recognition index, RI). RI in morphine dependent mice undergoing withdrawal was decreased compared to their control group. Brain corticosterone concentrations after naloxone withdrawal or 4 h after spontaneous withdrawal were respectively 22 and 34% greater than control values. Corticosterone concentration was normalized 14 h after the last dose of morphine. The results indicate that increase in brain corticosterone concentration may play an important role in short-term memory impairment following morphine withdrawal. © 2009 Informa UK Ltd All rights reserved.

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Style	Citing Format
MLA	Rabbani M, Hajhashemi V, Mesripour A. "Increase in Brain Corticosterone Concentration and Recognition Memory Impairment Following Morphine Withdrawal in Mice." Stress, vol. 12, no. 5, 2009, pp. 451-456.
APA	Rabbani M, Hajhashemi V, Mesripour A (2009). Increase in Brain Corticosterone Concentration and Recognition Memory Impairment Following Morphine Withdrawal in Mice. Stress, 12(5), 451-456.
Chicago	Rabbani M, Hajhashemi V, Mesripour A. "Increase in Brain Corticosterone Concentration and Recognition Memory Impairment Following Morphine Withdrawal in Mice." Stress 12, no. 5 (2009): 451-456.
Harvard	Rabbani M, Hajhashemi V, Mesripour A (2009) 'Increase in Brain Corticosterone Concentration and Recognition Memory Impairment Following Morphine Withdrawal in Mice', Stress, 12(5), pp. 451-456.
Vancouver	Rabbani M, Hajhashemi V, Mesripour A. Increase in Brain Corticosterone Concentration and Recognition Memory Impairment Following Morphine Withdrawal in Mice. Stress. 2009;12(5):451-456.
BibTex	@article{ author = {Rabbani M and Hajhashemi V and Mesripour A}, title = {Increase in Brain Corticosterone Concentration and Recognition Memory Impairment Following Morphine Withdrawal in Mice}, journal = {Stress}, volume = {12}, number = {5}, pages = {451-456}, year = {2009} }
RIS	TY - JOUR AU - Rabbani M AU - Hajhashemi V AU - Mesripour A TI - Increase in Brain Corticosterone Concentration and Recognition Memory Impairment Following Morphine Withdrawal in Mice JO - Stress VL - 12 IS - 5 SP - 451 EP - 456 PY - 2009 ER -