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Isfahan Thyroid Cohort Study (Itcs) Publisher Pubmed



Esfahani SS1 ; Tabatabaee A1 ; Aminorroaya A1 ; Amini M1 ; Feizi A2 ; Janghorbani M1 ; Tabatabaei A1 ; Meamar R3 ; Adibi A1 ; Abyar M1 ; Karimifar M1 ; Sajad R1 ; Salehidoost R1 ; Imani EF1 Show All Authors
Authors
  1. Esfahani SS1
  2. Tabatabaee A1
  3. Aminorroaya A1
  4. Amini M1
  5. Feizi A2
  6. Janghorbani M1
  7. Tabatabaei A1
  8. Meamar R3
  9. Adibi A1
  10. Abyar M1
  11. Karimifar M1
  12. Sajad R1
  13. Salehidoost R1
  14. Imani EF1
  15. Hovsepian S1
  16. Sirous M4
  17. Yamini SA5

Source: Archives of Iranian Medicine Published:2021


Abstract

Background: The Isfahan Thyroid Cohort Study (ITCS) is one of the few population-based epidemiological studies in Iran that investigates the prevalence and incidence of thyroid disorders including hypothyroidism, hyperthyroidism, goiter, nodule, and iodine status. Methods: This cohort is located in Isfahan, Iran. The first phase was initiated in 2006 with 2523 participants (1275 males, 1248 females). The participants were selected using multi-stage cluster sampling from the general residents of Isfahan, Iran. The study had two phases (2006 and 2011) and its third stage is planned for 2020-2021.Results: The prevalence of thyroid function states was euthyroid (89.3%, 95% CI: 88%-90%), overt hypothyroidism (2.8%, 95% CI: 2%-3%), subclinical hypothyroidism (5.8%, 95% CI: 4%-6%), overt hyperthyroidism (0.8%, 95% CI: 0.4%-1%), and subclinical hyperthyroidism (0.99%, 95% CI: 0.6%-1%). Hypothyroidism and hyperthyroidism were significantly associated with goiter. The incidence of thyroid dysfunction was reported as follows: Overt hypothyroidism (2.7, 95% CI: 1.6-3.7), subclinical hypothyroidism (20.6, 95% CI: 18-23), overt hyperthyroidism (1.9, 95% CI: 1-2.7) and subclinical hyperthyroidism (2.7, 95% CI: 1.6-3.7) per 1000 (person-year).Conclusion: We assessed the prevalence and incidence of thyroid disorders in Isfahan in the first and second phase, respectively. We are conducting the third phase of the ITCS in order to study the associations between thyroid peroxidase antibody (TPOAb) level and environmental factors such as infection. © 2021 Academy of Medical Sciences of I.R. Iran. All rights reserved.
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