Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Closure of Idiopathic Full-Thickness Macular Hole After Intravitreal C3f8 Injection Without Vitreomacular Traction Release: A Case Report and Review of Literature Publisher Pubmed



Fazel F1 ; Rezaeianramsheh A1 ; Fazel M1 ; Ahmadieh H1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Retinal Cases and Brief Reports Published:2024


Abstract

Background: The purpose of this study was to describe a successful closure of macular hole without release of vitreomacular traction after intravitreal perfluoropropane (C3F8) gas injection. Case Presentation: A 54-year-old woman was referred to our clinic with the history of declined vision after a period of distorted vision in her right eye. After dilated fundus examination and performing optical coherence tomography, a V-shaped vitreomacular traction complicated by full-thickness macular hole was diagnosed and she underwent pneumatic vitreolysis using intravitreal C3F8 gas injection. After 12 weeks, her visual acuity was significantly improved and fundus examination and optical coherence tomography revealed that the macular hole was completely resolved despite persisted vitreomacular traction. Conclusion: Intravitreal gas injection would be a promising option to manage idiopathic macular holes not only by releasing the vitreous traction on the macula but also through some not proven or even unknown mechanisms. © by Ophthalmic Communications Society, Inc. Unauthorized reproduction of this article is prohibited.
Related Docs
View other Related Docs
1. Inverted Ilm Flap Technique in Optic Disc Pit Maculopathy, Journal of Ophthalmic and Vision Research (2023)
2. Macular Branch Retinal Artery Occlusion As the First Manifestation of Ocular Toxoplasmosis, Retinal Cases and Brief Reports (2013)
3. Anatomic and Visual Outcomes of Scleral Buckling Versus Primary Vitrectomy in Pseudophakic and Aphakic Retinal Detachment: Six-Month Follow-Up Results of a Single Operation - Report No. 1, Ophthalmology (2005)
4. Macular Optical Coherence Tomography Angiographic Study in Children With a History of Prematurity: A Systematic Review and Meta-Analysis, Current Eye Research (2025)
5. The Effect of Combination Therapy With Intravitreal Bevacizumab and Topical Timolol–Dorzolamide Eye Drops on Diabetic Macular Edema: A Double-Blind Randomized Controlled Trial, International Ophthalmology (2024)
6. Phacoemulcification With Intravitreal Bevacizumab Injection in Patients With Cataract and Coexisting Diabetic Retinopathy: Prospective Randomized Study, Journal of Ocular Pharmacology and Therapeutics (2012)
7. Non-Steroidal Intravitreal Injection for Noninfectious Uveitic Cystoid Macular Edema: Systematic Review and Meta-Analysis, European Journal of Ophthalmology (2024)
8. A Successful Case of Intervention for Traumatic Central Retinal Artery Occlusion, Case Reports in Ophthalmology (2024)
Experts (# of related papers)
View all Related Experts
Heshmatollah Ghanbari (9)
Farzan Kianersi (9)
Other Related Docs
9. Evaluation of Intravitreal Injection of Bevacizumab (Avastin) in Treatment of Diabetic Macular Edema, Journal of Research in Medical Sciences (2012)
10. Relationship Between Macular Thickness and the Ratio of Vascular Endothelial Growth Factor to Its Soluble Receptor 1 in Non-Proliferative Diabetic Retinopathy, Journal of Isfahan Medical School (2012)
11. Peripapillary and Macular Choroidal Thickness in Both Eyes of Patients With Acute Unilateral Retrobulbar Optic Neuritis, Taiwan Journal of Ophthalmology (2020)
12. Intravitreal Bevacizumab for Management of Choroidal Osteoma Without Choroidal Neovascularization, Journal of Ophthalmic and Vision Research (2015)
13. Visual Outcome of Early and Late Pars Plana Vitrectomy in Patients With Dropped Nucleus During Phacoemulsification, Journal of Research in Medical Sciences (2011)
14. Effects of Subthreshold Diode Micropulse Laser Photocoagulation on Treating Patients With Refractory Diabetic Macular Edema, Journal of Current Ophthalmology (2019)
15. Epidemiologic Assessment of Pars Plana Vitrectomy in Feyz Ophthalmology Center, Isfahan, Iran, During 2011 to 2015, Journal of Isfahan Medical School (2017)
16. Baseline Subfoveal Choroidal Thickness As an Indicator for Bevacizumab Outcomes in Central Retinal Vein Occlusion, Tehran University Medical Journal (2019)
17. Acetazolamide and Bevacizumab Combination Therapy Versus Bevacizumab Monotherapy in Macular Edema Secondary to Retinal Vein Occlusion; [Traitement Combine Par Acetazolamide Et Bevacizumab Par Rapport a La Monotherapie Par Bevacizumab Dans L’Oedeme Maculaire Secondaire a Une Occlusion Veineuse Retinienne], Journal Francais d'Ophtalmologie (2023)
18. Retinal Vascular Changes After Silicon Oil Removal in the Eye With Rhegmatogenous Retinal Detachment, International Journal of Retina and Vitreous (2024)
19. The Effect of Silicone Oil Tamponade on Retinal Layers and Choroidal Thickness in Patients With Rhegmatogenous Retinal Detachment: A Systematic Review and Meta-Analysis, International Journal of Retina and Vitreous (2021)
20. Intravitreal Diclofenac for Treatment of Refractory Uveitis-Associated Cystoid Macular Oedema: A Before and After Clinical Study, Acta Ophthalmologica (2018)
21. Combination of Intravitreal Bevacizumab and Topical Dorzolamide Versus Intravitreal Bevacizumab Alone for Diabetic Macular Edema: A Randomized Contralateral Clinical Trial, BioMed Research International (2020)
22. Intravitreal Bevacizumab Versus Ranibizumab: Effects on the Vessels of the Fellow Non-Treated Eye, Journal of Current Ophthalmology (2019)
23. Evaluating the Efficacy and Safety of Aflibercept Biosimilar (P041) Compared With Originator Product in Patients With Neovascular Age-Related Macular Degeneration, Ophthalmology Retina (2024)
24. Intravitreal Fasudil Monotherapy for Treatment of Refractory Diabetic Macular Edema: A Prospective Interventional Case Series; [Monotherapie Intravitreenne Par Fasudil Pour Le Traitement De L’Oedeme Maculaire Diabetique Refractaire : Une Serie De Cas Interventionnels Prospectifs], Journal Francais d'Ophtalmologie (2023)
25. Intravitreal Bevacizumab for Treatment of Choroidal Neovascularization Secondary to Toxoplasmic Retinochoroiditis: A Case Series, Seminars in Ophthalmology (2015)
26. Intravitreal Injections of Bevacizumab Plus Methotrexate Versus Bevacizumab Alone for the Treatment of Diabetic Macular Edema: A Randomized, Sham-Controlled Trial, Journal of Current Ophthalmology (2020)
27. Retinal Findings of Covid-19 Patients Using Ocular Coherence Tomography Angiography Two to Three Months After Infection: Ocular Appearance Recovered Covid-19 Patient, Photodiagnosis and Photodynamic Therapy (2022)
28. Intravitreal Diclofenac Plus Bevacizumab Versus Bevacizumab Alone in Treatment-Naive Diabetic Macular Edema: A Randomized Double-Blind Clinical Trial, International Ophthalmology (2017)
29. Ophthalmic Artery Occlusion Following Facial Sclerosing Therapy, Journal of Ophthalmic and Vision Research (2018)
30. The Additive Effect of Intravitreal Dexamethasone Combined With Bevacizumab in Refractory Diabetic Macular Edema; [L'effet Additif De La Dexamethasone Intravitreenne Associee Au Bevacizumab Dans L’Oedeme Maculaire Diabetique Refractaire], Journal Francais d'Ophtalmologie (2023)