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Saffron and Sleep Quality: A Systematic Review of Randomized Controlled Trials Publisher



Sadat Rafiei SK1 ; Abolghasemi S2 ; Frashidi M3 ; Ebrahimi S4 ; Gharei F1 ; Razmkhah Z5 ; Tavousi N6 ; Mahmoudvand B7 ; Faani M1 ; Karimi N8 ; Abdi A8 ; Soleimanzadeh M9 ; Ahmadpour Youshanlui M3 ; Sadatmadani SF10 Show All Authors
Authors
  1. Sadat Rafiei SK1
  2. Abolghasemi S2
  3. Frashidi M3
  4. Ebrahimi S4
  5. Gharei F1
  6. Razmkhah Z5
  7. Tavousi N6
  8. Mahmoudvand B7
  9. Faani M1
  10. Karimi N8
  11. Abdi A8
  12. Soleimanzadeh M9
  13. Ahmadpour Youshanlui M3
  14. Sadatmadani SF10
  15. Alikhani R11
  16. Pishkari Y12
  17. Deravi N1
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  3. 3. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
  5. 5. Student Research Committee, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Student Research committee, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Student Research Committee, School of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  9. 9. Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  11. 11. Tehran University of Medical Science, Tehran, Iran
  12. 12. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Nutrition and Metabolic Insights Published:2023


Abstract

Background: Sleep quality is defined as an individual’s consent to sleep experience. Poor sleep quality has important adverse health outcomes. There are drugs to treat sleep disorders but consumption of these drugs is accompanied by adverse effects whereas herbal treatments have fewer side effects. Saffron is spice obtained from Crocus sativus flower. Several articles have been done on its effects on the quality of sleep and its safety. This review for the first time critically evaluates effect of saffron on sleep quality improvement. Method: The search technique aims to get all related published data-based up to 2022 articles. PubMed, Central, Google Scholar, and Scopus were examined. Only full reports were evaluated (abstracts were excluded). The first screening was done by title and abstract. Then full text of articles was read and irrelevant articles were removed. Duplicate articles were also removed by Endnote. By using Cochrane risk of bias tool assessment, a quality score based on probability of bias was given. Methodological characteristics were also evaluated using the criteria of Stevinson and Ernst. Result: In the systematic review, 5 randomized clinical trials with 379 participants from 3 countries were identified. In placebo-comparison trials, saffron contains a large treatment. Conclusion: It seems that saffron has a beneficial influence on duration and quality of sleep. Saffron, crocin, and safranal induce hypnotic effects by increasing the duration of sleep. Research conducted so far provides initial support and safety for use of saffron to improve sleep quality. © The Author(s) 2023.
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