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Saffron Improves Life and Sleep Quality, Glycaemic Status, Lipid Profile and Liver Function in Diabetic Patients: A Double-Blind, Placebo-Controlled, Randomised Clinical Trial Publisher Pubmed



Tajaddini A1 ; Roshanravan N2 ; Mobasseri M3 ; Aeinehchi A4 ; Sefidmooye Azar P4 ; Hadi A5 ; Ostadrahimi A1
Authors
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Authors Affiliations
  1. 1. Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Endocrinology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Clinical Practice Published:2021


Abstract

Background: Type 2 diabetes (T2D) is a metabolic disorder that is related to hyperglycaemia, hyperlipidaemia and liver dysfunction and has detrimental effects on a patient's mental health. Hence, the current study investigated the effects of saffron supplementation on dietary intake, anthropometric measures, mood, sleep quality and metabolic biomarkers in overweight/obese patients with T2D. Methods: In a double-blind, randomised controlled trial, 70 overweight/obese patients with T2D were randomly allocated to two groups and received 100 mg/day saffron or placebo for 8 weeks. Participants completed the Beck depression inventory-II (BDI-II), Hurlbert index of sexual desire (HISD), Pittsburgh Sleep Quality Index (PSQI) and Diabetes-specific Quality-of-Life Brief Clinical Inventory questionnaires (DQOL-BCI). Dietary intake, anthropometric measures, fasting plasma glucose (FPG), haemoglobin A1C (HbA1C), insulin, lipid profile and liver enzymes were determined at baseline and the end of the study. Results: At the end of the eighth week, saffron supplementation significantly decreased FPG, triglyceride (TG), insulin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (P <.001). Moreover, significant improvements in BDI-II scores and total quality of life were observed in the intervention group (P <.001). The saffron group showed more significant improvements in PSQI scores than the placebo group, such that at the post-intervention analysis, only the saffron group achieved a “good” sleep band. At this relatively high dose, saffron supplementation improved glycaemic status, lipid profile and liver enzyme measures in patients with T2D while also improving sleep and overall quality of life. Conclusion: Our results indicate that saffron notably reduced hyperglycaemia and hyperlipidaemia and improved liver function in patients with T2D in an 8-week randomised clinical trial. Saffron also significantly improved depression, sleep quality and overall quality of life in diabetic patients. However, further investigation is necessary to confirm whether saffron is an effective complementary therapy for T2D. © 2021 John Wiley & Sons Ltd
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