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The Association Between Oral Contraceptive Pills and Ovarian Cancer Risk: A Systematic Review and Meta-Analysis; [Association Entre Pilules Contraceptives Orales Et Risque De Cancer De L'ovaire: Une Revue Systematique Et Une Meta-Analyse] Publisher Pubmed



Arshadi M1 ; Hesari E2 ; Ahmadinezhad M2 ; Yekta EM2 ; Ebrahimi F3 ; Azizi H4 ; Esfarjani SV5 ; Rostami M5 ; Khodamoradi F6
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Authors Affiliations
  1. 1. Department of Epidemiology and Biostatistics, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  2. 2. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Social Medicine, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Bulletin du Cancer Published:2024


Abstract

Introduction: Previous study results have been inconclusive, so this meta-analysis aims to evaluate the association between ovarian cancer and oral contraceptive pills (OCPs). Methods: PubMed, EMBASE, Scopus, and Web of Science were searched to identify studies on the association between OCPs and ovarian cancer from January 1, 2000 through February 5, 2023. The pooled relative risk (RR) and odds ratio (OR) were used to measure this relationship. Results: A total of 67 studies were included. In the association between ever-use compared with never-use of OCPs and ovarian cancer risk, the pooled RR in cohort studies was 0.69 [95% CI: 0.61, 0.78]. For the relationship between duration of OCPs use and ovarian cancer in the cohort studies, no association between duration of use1–12 months 0.92 [95% CI: 0.82, 1.03] and duration of use 13–60 months 0.87 [95% CI: 0.73, 1.04], but there is a statistically significant inverse relationship between duration of use 61–120 months 0.62 [95% CI: 0.48, 0.81] and more than 120 months 0.51 [95% CI: 0.32, 0.80] and ovarian cancer. For the relationship between OCPs and histological subtype of epithelial ovarian cancer in the cohort studies, the pooled RR for invasive was 0.70 [95% CI: 0.56, 0.87], but no association between OCPs and borderline ovarian cancer 0.64 [95% CI: 0.31, 1.31]. Conclusion: Our analysis shows a statistically significant inverse relationship between ever-use compared to never-use of OCPs and ovarian cancer risk,and also between invasive cancer and OCPs. By increasing the duration of OCPs use, the risk of ovarian cancer decreased. © 2024 Societe Francaise du Cancer
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