Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Mixed Aggregate Formation in Gemini Surfactant/1,2-Dialkyl-Sn-Glycero-3-Phosphoethanolamine Systems Publisher Pubmed



Akbar J1 ; Tavakoli N1, 3 ; Gerrard Marangoni D2 ; Wettig SD1
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Pharmacy, University of Waterloo, Kitchener, ON, N2G 1C5, 10 Victoria Str. S., Canada
  2. 2. Department of Chemistry, St. Francis Xavier University, Antigonish, NS, B2G 2W5, P.O. Box 5000, Canada
  3. 3. School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Box 81746-73471, Iran

Source: Journal of Colloid and Interface Science Published:2012


Abstract

An evaluation of the physical interactions between gemini surfactants, DNA, and 1,2-dialkyl-sn-glycero-3-phosphoethanolamine helper lipid is presented in this work. Complexation between gemini surfactants and DNA was first investigated using surface tensiometry where the surface tension profiles obtained were found to be consistent with those typically observed for mixed surfactant-polymer systems; that is, there is a synergistic lowering of the surface tension, followed by a first (CAC) and second (CMC) break point in the plot. The surfactant alkyl tail length was observed to exhibit a significant effect on the CAC, thus demonstrating the importance of hydrophobic interactions during complexation between gemini surfactants and DNA. The second study presented is an investigation of the mixing interactions between gemini surfactants and DOPE using Clint's, Rubingh's, and Motomura's theories for mixed micellar formation. The mixing interactions between the 16-3-16/16-7-16/16-12-16/16-7NH-16 gemini surfactants and DOPE were observed to be antagonistic, where the strength of antagonism was found to be dependent upon the gemini surfactant spacer group and the solution composition. © 2012 Elsevier Inc..
Related Docs
1. Parent and Nano-Encapsulated Ytterbium(Iii) Complex Toward Binding With Biological Macromolecules,: In Vitro Cytotoxicity, Cleavage and Antimicrobial Activity Studies, RSC Advances (2020)
2. Transfection and Structural Properties of Phytanyl Substituted Gemini Surfactant-Based Vectors for Gene Delivery, Physical Chemistry Chemical Physics (2013)