Parent and Nano-Encapsulated Ytterbium(Iii) Complex Toward Binding With Biological Macromolecules,: In Vitro Cytotoxicity, Cleavage and Antimicrobial Activity Studies

Parent and Nano-Encapsulated Ytterbium(Iii) Complex Toward Binding With Biological Macromolecules,: In Vitro Cytotoxicity, Cleavage and Antimicrobial Activity Studies Publisher

Arameshboroujeni Z^{1, 2} ; Jahani S³ ; Khorasanimotlagh M⁴ ; Kerman K⁵ ; Noroozifar M⁵

Show Affiliations

1. Department of Clinical Laboratory, AlZahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
2. Young Researchers and Elite Club, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran
3. Nano Bioeletrochemistry Research Center, Bam University of Medical Sciences, Bam, Iran
4. Department of Chemistry, University of Sistan and Baluchestan, Zahedan, 98135-674, Iran
5. Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, M1C 1A4, ON, Canada

Source: RSC Advances Published:2020

Abstract

To determine the chemotherapeutic and pharmacokinetic aspects of an ytterbium complex containing 2,9-dimethyl-1,10-phenanthroline (Me2Phen), in vitro binding studies were carried out with FS-DNA/BSA by employing multiple biophysical methods and a molecular modeling study. There are different techniques including absorption spectroscopy, fluorescence spectroscopy, circular dichroism studies, viscosity experiments (only in the case of DNA), and competitive experiments used to determine the interaction mode between DNA/BSA and the ytterbium-complex. The results showed that the Yb-complex exhibited a high propensity for the interaction of BSA and DNA via hydrophobic interactions and van der Waals forces. Further, a competitive examination and docking study showed that the interaction site of the ytterbium complex on BSA is site III. The results of docking calculations for DNA/BSA were in good agreement with experimental findings. The complex displays efficient DNA cleavage in the presence of hydrogen peroxide. Moreover, antimicrobial studies of different bacteria and fungi indicated its promising antibacterial activity. In vitro cytotoxicity studies of the Yb-complex, starch nano-encapsulated, and lipid nano-encapsulated were carried out in MCF-7 and A-549 cell lines, which revealed significantly good activity. The results of anticancer activity studies showed that the cytotoxic activity of the Yb-complex was increased when encapsulated with nanocarriers. Based on biological applications of the Yb-complex, it can be concluded that this complex and its nanocarriers can act as novel anticancer and antimicrobial candidates. This journal is © The Royal Society of Chemistry.

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Style	Citing Format
MLA	Arameshboroujeni Z, et al.. "Parent and Nano-Encapsulated Ytterbium(Iii) Complex Toward Binding With Biological Macromolecules,: In Vitro Cytotoxicity, Cleavage and Antimicrobial Activity Studies." RSC Advances, vol. 10, no. 39, 2020, pp. 23002-23015.
APA	Arameshboroujeni Z, Jahani S, Khorasanimotlagh M, Kerman K, Noroozifar M (2020). Parent and Nano-Encapsulated Ytterbium(Iii) Complex Toward Binding With Biological Macromolecules,: In Vitro Cytotoxicity, Cleavage and Antimicrobial Activity Studies. RSC Advances, 10(39), 23002-23015.
Chicago	Arameshboroujeni Z, Jahani S, Khorasanimotlagh M, Kerman K, Noroozifar M. "Parent and Nano-Encapsulated Ytterbium(Iii) Complex Toward Binding With Biological Macromolecules,: In Vitro Cytotoxicity, Cleavage and Antimicrobial Activity Studies." RSC Advances 10, no. 39 (2020): 23002-23015.
Harvard	Arameshboroujeni Z et al. (2020) 'Parent and Nano-Encapsulated Ytterbium(Iii) Complex Toward Binding With Biological Macromolecules,: In Vitro Cytotoxicity, Cleavage and Antimicrobial Activity Studies', RSC Advances, 10(39), pp. 23002-23015.
Vancouver	Arameshboroujeni Z, Jahani S, Khorasanimotlagh M, Kerman K, Noroozifar M. Parent and Nano-Encapsulated Ytterbium(Iii) Complex Toward Binding With Biological Macromolecules,: In Vitro Cytotoxicity, Cleavage and Antimicrobial Activity Studies. RSC Advances. 2020;10(39):23002-23015.
BibTex	@article{ author = {Arameshboroujeni Z and Jahani S and Khorasanimotlagh M and Kerman K and Noroozifar M}, title = {Parent and Nano-Encapsulated Ytterbium(Iii) Complex Toward Binding With Biological Macromolecules,: In Vitro Cytotoxicity, Cleavage and Antimicrobial Activity Studies}, journal = {RSC Advances}, volume = {10}, number = {39}, pages = {23002-23015}, year = {2020} }
RIS	TY - JOUR AU - Arameshboroujeni Z AU - Jahani S AU - Khorasanimotlagh M AU - Kerman K AU - Noroozifar M TI - Parent and Nano-Encapsulated Ytterbium(Iii) Complex Toward Binding With Biological Macromolecules,: In Vitro Cytotoxicity, Cleavage and Antimicrobial Activity Studies JO - RSC Advances VL - 10 IS - 39 SP - 23002 EP - 23015 PY - 2020 ER -

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