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Precision in Cancer Diagnostics: Ultra-Sensitive Detection of Mcf-7 Breast Cancer Cells by Gold Nanostructure-Enhanced Electrochemical Biosensing Publisher Pubmed



Rahmanipour M1 ; Siampour H3 ; Moshaii A1, 2 ; Amirabadizadeh M4 ; Fouani MH4 ; Shariati L5, 6 ; Rafienia M3
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Authors Affiliations
  1. 1. Department of Physics, Tarbiat Modares University, Tehran, P.O. Box: 14115-175, Iran
  2. 2. Department of Sensor and Biosensor, Faculty of Interdisciplinary Sciences and Technologies, Tarbiat Modares University, Tehran, P.O. Box: 14115-336, Iran
  3. 3. Biosensor Research Center (BRC), Isfahan University of Medical Sciences, Isfahan, P.O. Box: 81746-73461, Iran
  4. 4. Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, P.O. Box: 14115-154, Tehran, Iran
  5. 5. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Biomaterials, Nanotechnology and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Materials Chemistry B Published:2024


Abstract

Timely identification of cancers is pivotal in optimizing treatment efficacy and reducing their widespread impact. This study introduces a novel biosensor for the sensitive electrochemical detection of cancer cells overexpressing mucin 1 (MUC1), a well-established model for breast cancer. The sensor substrate comprises gold columnar nanostructures obtained through glancing angle deposition (GLAD) of copper nanostructures, subsequently replaced by gold via a facile galvanic replacement process. Functionalizing these gold nanostructures with aptamers targeting the MUC1 glycoproteins, a prominent cancer biomarker, enables specific recognition of MCF-7 breast cancer cells. The proposed electrochemical sensing platform offers several advantages, including high selectivity, a wide linear range of detection, a low detection limit of 30 cells per mL, and long-term stability, rendering this sensor highly desirable for definitive breast cancer diagnosis. © 2024 The Royal Society of Chemistry.
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