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Electrochemical Biosensors for Early Detection of Breast Cancer Publisher Pubmed



Kiani P1 ; Vatankhahan H2 ; Zarehoseinabadi A3 ; Ferdosi F4 ; Ehtiati S5 ; Heidari P6 ; Dorostgou Z7 ; Movahedpour A8 ; Baktash A9 ; Rajabivahid M10 ; Khatami SH11
Authors
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Authors Affiliations
  1. 1. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  7. 7. Department of Biochemistry, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
  8. 8. Behbahan Faculty of Medical Sciences, Behbahan, Iran
  9. 9. Department of Medicine, Research Center for Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
  10. 10. Department of Internal Medicine, Valiasr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
  11. 11. Student Research Committee, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Clinica Chimica Acta Published:2025


Abstract

Breast cancer continues to be a significant contributor to global cancer deaths, particularly among women. This highlights the critical role of early detection and treatment in boosting survival rates. While conventional diagnostic methods like mammograms, biopsies, ultrasounds, and MRIs are valuable tools, limitations exist in terms of cost, invasiveness, and the requirement for specialized equipment and trained personnel. Recent shifts towards biosensor technologies offer a promising alternative for monitoring biological processes and providing accurate health diagnostics in a cost-effective, non-invasive manner. These biosensors are particularly advantageous for early detection of primary tumors, metastases, and recurrent diseases, contributing to more effective breast cancer management. The integration of biosensor technology into medical devices has led to the development of low-cost, adaptable, and efficient diagnostic tools. In this framework, electrochemical screening platforms have garnered significant attention due to their selectivity, affordability, and ease of result interpretation. The current review discusses various breast cancer biomarkers and the potential of electrochemical biosensors to revolutionize early cancer detection, making provision for new diagnostic platforms and personalized healthcare solutions. © 2024 Elsevier B.V.
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