Recent Advances in the Design and Development of Non-Nucleoside Reverse Transcriptase Inhibitor Scaffolds

Recent Advances in the Design and Development of Non-Nucleoside Reverse Transcriptase Inhibitor Scaffolds Publisher Pubmed

Shirvani P¹ ; Fassihi A¹ ; Saghaie L¹

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1. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Science, Hezar Jerib Avenue, Isfahan, 81746-73461, Iran

Source: ChemMedChem Published:2019

Abstract

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have always been an important part of the anti-HIV-1 combination therapy known as combination antiretroviral therapy (cART) since 1996. The use of NNRTIs for about 22 years has led to some mutations in the residues that compose the reverse transcriptase active site, resulting in the emergence of drug-resistant viruses. Thus, the search for new potent NNRTIs with an improved safety profile and activity against drug-resistant HIV strains is indispensable, and many hit and lead NNRTIs have been discovered in the last decade. This review provides an overview of the development in this field from 2013 to August 2018. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

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4. Evaluation of the in Vitro Antiretroviral Potential of Some Biginelli-Type Pyrimidines, Acta Virologica (2012)

5. Docking Studies of Some 5-Hydroxypyridine-4-One Derivatives: Evaluation of Integrase and Ribonuclease H Domain of Reverse Transcriptase As Possible Targets for Anti-Hiv-1 Activity, Medicinal Chemistry Research (2015)

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7. Designing a Non-Virulent Hiv-1 Strain: Potential Implications for Vaccine and Experimental Research, Journal of Research in Medical Sciences (2007)

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Afshin Fassihi (6)

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Style	Citing Format
MLA	Shirvani P, Fassihi A, Saghaie L. "Recent Advances in the Design and Development of Non-Nucleoside Reverse Transcriptase Inhibitor Scaffolds." ChemMedChem, vol. 14, no. 1, 2019, pp. 52-77.
APA	Shirvani P, Fassihi A, Saghaie L (2019). Recent Advances in the Design and Development of Non-Nucleoside Reverse Transcriptase Inhibitor Scaffolds. ChemMedChem, 14(1), 52-77.
Chicago	Shirvani P, Fassihi A, Saghaie L. "Recent Advances in the Design and Development of Non-Nucleoside Reverse Transcriptase Inhibitor Scaffolds." ChemMedChem 14, no. 1 (2019): 52-77.
Harvard	Shirvani P, Fassihi A, Saghaie L (2019) 'Recent Advances in the Design and Development of Non-Nucleoside Reverse Transcriptase Inhibitor Scaffolds', ChemMedChem, 14(1), pp. 52-77.
Vancouver	Shirvani P, Fassihi A, Saghaie L. Recent Advances in the Design and Development of Non-Nucleoside Reverse Transcriptase Inhibitor Scaffolds. ChemMedChem. 2019;14(1):52-77.
BibTex	@article{ author = {Shirvani P and Fassihi A and Saghaie L}, title = {Recent Advances in the Design and Development of Non-Nucleoside Reverse Transcriptase Inhibitor Scaffolds}, journal = {ChemMedChem}, volume = {14}, number = {1}, pages = {52-77}, year = {2019} }
RIS	TY - JOUR AU - Shirvani P AU - Fassihi A AU - Saghaie L TI - Recent Advances in the Design and Development of Non-Nucleoside Reverse Transcriptase Inhibitor Scaffolds JO - ChemMedChem VL - 14 IS - 1 SP - 52 EP - 77 PY - 2019 ER -

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