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Healing Effect of Pilocarpine Gel 4% on Skin Lesions of Pemphigus Vulgaris Publisher Pubmed



Iraji F1 ; Yoosefi A1
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Authors Affiliations
  1. 1. Department of Dermatology, AL-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Dermatology Published:2006


Abstract

Background: The high rate of morbidity and mortality resulting from long-term use of corticosteroids in pemphigus vulgaris (PV) warrants discovery of a new treatment strategy. Based on a new theory on the pathophysiology of PV, cholinomimetics can block the process of blister formation. Aims: This study was conducted to evaluate the clinical effectiveness of Pilocarpine gel in the treatment of skin lesions of PV. Methods: In a double-blind, placebo-controlled study, three PV patients with a total of 64 skin lesions were treated by either Pilocarpine or placebo gel. After 15 days of treatment an epithelialization index of the two groups was compared. Results: The mean of the epithelialization index in skin lesions that received Pilocarpine was significantly higher than that of the placebo group (40.3 ± 1.7 vs. 24.4 ± 3.3, P < 0.001). Conclusions: Pilocarpine gel effectively treats PV. © 2006 The International Society of Dermatology.
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